Current literature merely identifies the driving factors of research productivity in higher education institutions without directly examining their interrelationships that would offer some fundamental insights into the nature of these factors. Thus, this work intends to identify those driving factors and establish their structural relationships to determine those factors with crucial roles in advancing research productivity. Due to the subjectivity of the identified driving factors and the notion that the evaluation of their relationships reflects an expert judgment, an interpretive structural modeling (ISM) approach and the Matrice d’impacts croisés multiplication appliquée á un classment (MICMAC) analysis were adopted. Results show that institutional support, reward system, research funding, mentoring, and electronic information resources are the most crucial factors influencing research productivity. When addressed, these driving factors would motivate other driving factors, contributing to higher research productivity. In particular, these findings encourage higher education institutions to (1) efficiently allocate research funds and design mentoring programs, (2) offer efficient research incentive schemes, (3) develop initiatives that would support promising research proposals beneficial to the institution, and (4) collaborate with external organizations to grant funding for research proposals. These results contribute significantly to the literature as it provides meaningful insights that aid decision-makers in higher education institutions in resource allocation decisions, policy-making, and the design of efficient initiatives for augmenting their innovation potential.