The Role of Multifocal Electroretinography in the Assessment of Drug-Induced Retinopathy: A Review of the Literature

Dettoraki, Maria; Moschos, Marilita M.

doi:10.1159/000446321

Cited by 25 publications

(26 citation statements)

References 82 publications

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“…mfERG is a useful tool for detecting various retinal abnormalities that are not obvious in fundus examination 16–18. Initially, our patient showed slight anatomical disturbance in fundus examination and OCT, however, mfERG a month later identified significant abnormalities in macular function.…”

Section: Discussionmentioning

confidence: 70%

Maculopathy from an accidental exposure to welding arc

et al. 2019

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Welding light can cause photic retinal injury. We report binocular maculopathy induced by a brief exposure to electric arc welding light in a patient who could not equipped with protective device because of narrow space. A 47-year-old man performed electric arc welding for approximately 10–15 min without wearing protective device because of narrow space and subsequently experienced eye discomfort and decreased visual acuity. At the initial visit, his best corrected visual acuity was 0.5. Fundus examination, optical coherence tomography (OCT) and multifocal electroretinogram (mfERG) were performed. OCT showed disruption in the ellipsoid zone, and mfERG amplitudes in the central 10° were markedly reduced in both eyes. The decrease in visual acuity had been noted for at least 18 months. Using the proper protective device is essential in welding, despite short time periods of work. For patients with welding-induced photokeratitis, doctors should also consider the possibility of photic retinal injury.

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Section: Discussionmentioning

confidence: 70%

Maculopathy from an accidental exposure to welding arc

et al. 2019

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“…It has been shown that in all types of maculopathy there is a decrease or loss of central electrical response, which is related to the degree and extent of the lesion. MfERG is a valuable method particularly in cases where the patient is visually asymptomatic, visual acuity is normal and macular lesions are not clearly visible ophthalmoscopically [ 31 ]. MfERG reflects the electrophysiological responses mainly from the inner retinal layers.…”

Section: Discussionmentioning

confidence: 99%

Effect of carotenoids dietary supplementation on macular function in diabetic patients

et al. 2017

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BackgroundDiabetic retinopathy is a major cause of visual impairment and blindness among working-age people worldwide. The aim of our study was to investigate the effects of a carotenoid supplementation on retinal thickness and macular function of patients with diabetes using optical coherence tomography (OCT) and multifocal electroretinography (mfERG).MethodsA retrospective study of one hundred and twenty eyes of sixty patients age between 40 and 60 years with non-insulin dependent type 2 diabetes mellitus without diabetic retinopathy who underwent OCT and mfERG and took vitamin supplements for a period of two years. Patients received a carotenoid supplement containing lutein (10 mg), zeaxanthin (2 mg) and meso-zeaxanthin (10 mg) once a day for two years. The thickness of the fovea was evaluated using OCT and the macular function was tested by mfERG.ResultsOCT showed an increase in the central foveal thickness and mfERG revealed increased retinal response density within the central 13° surrounding the fovea (rings 1 to 3) at two years after the onset of carotenoids supplement intake.ConclusionThe use of carotenoid supplements may be of benefit for improving visual function of type 2 diabetes patients. However, further study is needed to assess the treatment’s long-term efficacy.

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“…[ 6 ] Medications commonly known to produce retinal toxicity include chloroquine and hydroxychloroquine, vigabatrin, deferoxamine, ethambutol, interferon-α, tamoxifen, digoxin, sildenafil, canthaxanthin, aminoglycosides, and amiodarone. [ 6 7 ]…”

Section: Discussionmentioning

confidence: 99%

Methoxsalen-induced macular toxicity

Maitray

Rishi

2017

Indian J Ophthalmol

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Psoralen compounds such as methoxsalen are photosensitizer agents used in conjunction with ultraviolet A (UVA) radiation exposure as photochemotherapy (Psoralens and ultraviolet-A therapy [PUVA therapy]) for certain epidermal skin disorders such as psoriasis and vitiligo. Methoxsalen has been shown to be associated with premature cataract formation by forming adducts with lens proteins following oral administration and subsequent UVA exposure. Hence, the use of UV-filtering glasses is recommended during PUVA therapy sessions. Ocular tissues can be exposed to its photosensitizing effect with subsequent UV radiation exposure through sunlight if the patient was to be without protective eye glasses, potentially causing macular toxicity. Till date, there have been no reports in the literature of any posterior segment ocular toxicity arising from methoxsalen use. Here, we describe a case of a bilateral macular toxicity in a middle-aged male treated with methoxsalen for vitiligo.

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The Role of Multifocal Electroretinography in the Assessment of Drug-Induced Retinopathy: A Review of the Literature

Cited by 25 publications

References 82 publications

Maculopathy from an accidental exposure to welding arc

Maculopathy from an accidental exposure to welding arc

Effect of carotenoids dietary supplementation on macular function in diabetic patients

Methoxsalen-induced macular toxicity

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