The role of multimodality imaging in the diagnosis of left ventricular noncompaction

Rao, Karan; Bhaskaran, Ashwin; Choudhary, Preeti; Tan, Timothy C.

doi:10.1111/eci.13254

Cited by 9 publications

(12 citation statements)

References 86 publications

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“…Although there is no unanimously accepted non-compaction diagnostic gold standard, one of the main criteria used in the clinical practice are the echocardiographic criteria described by Jenni et al in 2001: the ratio of non-compact to compact myocardial layers (NCM:CM) is greater than 2 at the end of systole, the non-compaction of myocardium is expressed in the localizations typical for this pathology, the colour Doppler method shows blood flow in the intertrabecular pockets, and no concomitant cardiac disorders are found in the patient [22,23]. However, despite the simplicity and widespread use of echocardiography, the present study distinguished in low reproducibility of the test results, it is difficult to visualize the apex of the cardiac myocardium, which is one of the most common sites of myocardial trabeculation, and the sensitivity of these echocardiographic criteria is only up to 64% [24,25]. CMR, compared to transthoracic echocardiography, is a superior technique which provides additional information on cardiac morphology and more accurately assesses the extent of non-compact myocardium, thus allowing better sensitivity in respect of NCC diagnosis [26].…”

Section: Introductionmentioning

confidence: 60%

Magnetic resonance diagnostic criteria of non-compaction cardiomyopathy: new diagnostic criteria still needed?

Gaižauskienė

Glembockytė

Glaveckaitė

et al. 2023

Seminars in Cardiovascular Medicine

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Summary Non-compaction cardiomyopathy (NCC) is a rare pathology, but the exact rates of its prevalence are not known due to the lack of a diagnostic gold standard. The purpose of this article is to analyse the available cardiovascular magnetic resonance (CMR) diagnostic criteria of non-compaction described in the literature and to compare their sensitivity and specificity in the diagnosis of NCC. A search of available literature related to the CMR diagnostic criteria of myocardial non-compaction was conducted in the medical database PubMed in February of 2022. The period of publication of scientific articles covered the years from 1996 to 2022. A total of 7 full-text scientific articles were included in the final literature review. The main diagnostic criteria were used: the maximum non-compact (NCM) to compact myocardial layers (CM) ratio (NCM:CM), the percentage of trabeculated left ventricular (LV) myocardial mass, the percentage of trabeculated LV myocardial volume, the non-compact myocardial mass index of the total LV, and the determination of the total LV and the maximal fractal dimension (FD) of the apex with the use of fractal analysis. The lack of accurate diagnostic criteria results in an overdiagnosis of NCC. The highest sensitivity and specificity are associated with the maximum FD > 1.30 of the apex established by applying the fractal analysis method. Fractal analysis requires dedicated software, and this method is difficult to apply in routine clinical practice. Thus, the diagnostic criteria for the NCC using magnetic resonance imaging with higher diagnostic value remain to be sought.

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Section: Introductionmentioning

confidence: 60%

Magnetic resonance diagnostic criteria of non-compaction cardiomyopathy: new diagnostic criteria still needed?

Gaižauskienė

Glembockytė

Glaveckaitė

et al. 2023

Seminars in Cardiovascular Medicine

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“…Существенным ограничением ЭхоКГ в сравнении с МРТ при оценке структурных изменений ЛЖ является неудовлетворительная визуализация миокарда [15]. Для устранения ограничений, свойственных ультразвуковым исследованиям и имеющимся в предыдущих исследованиях, для лучшей визуализации границы некомпактного и компактного слоев миокарда ЛЖ мы использовали транспульмональный контрастный препарат.…”

Section: Discussionunclassified

Diagnostic value of standard and modified echocardiographic criteria for left ventricular noncompaction

Корецкий¹,

Мершина

Мясников³

et al. 2021

Cardiovasc Ther Prev

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Aim. To assess the diagnostic value of standard and modified ultrasound criteria for left ventricular noncompaction (LVNC).Material and methods. The study included 37 patients. All patients underwent echocardiography and magnetic resonance imaging (MRI). Patients with any of the standard echocardiographic criteria for LVNC (Chin, Jenni, Stollberger) were included in the study. We studied modified echocardiographic criteria of LVNC in 4 and 3-chamber apical views in systole and diastole in the anterolateral (ALsist and ALdiast) and posterolateral (PLsist and PLdiast) walls with the non-compact to compact layer ratio (NC/C) >2. To assess the diagnostic value of the echocardiographic LVNC criteria, the specificity (SP) and sensitivity (SN), the likelihood ratio for positive (LR+) and negative (LR-) test results were calculated, and the operating characteristic curve (ROC) was analyzed.Results. The study included 19 women (51,4%) and 18 men (48,6%), aged 18 to 69 years. The mean age of the patients was 37,7±12,6 years. Relative to the Petersen's MRI-criterion for the Chin's criterion, SN was 55%, SP — 53% (LR+ =1,2, LR- =0,9); for the Jenni's criterion, SN — 55%, SP — 35% (LR+ =0,9, LR- =1,3); for the Stollberger's criterion, SN — 70%, SP — 18% (LR+ =0,9, LR- =1,7); for PLsyst criterion, SP — 82%, SN — 50% (LR+ =2,8, LR- =0,6). Relative to the Grothoff's MRI-criterion, which determined the LVNC mass as a percentage, for the Chin's criterion, SN was 69%, SP — 58% (LR+ =of 1,7, LR- =0,5); for the Jenni's criterion, SN — 85%, SP — 54% (LR+ =1,9, LR- =0,3); for the Stollberger's criterion, SN — 77%, SP — 25% (LR+ =1,0, LR- =0,9); for PLdiast criterion SP — 79%, SN — 62% (LR+ =3,0, LR- =0,5); for PLsyst criterion SP — 63%, SN — 84% (LR+ of 2,2, LR- =0,3); for ALdiast criterion, SP — 83%, SN — 69% (LR+ =4,1, LR- =0,4); for ALsyst criterion, SP — 71%, SN — 92% (LR+ =3,1, LR- =0,1). Relative to the Grothoff's MRI-criterion, which determined the LVNC mass index, for the Chin's criterion, SN was 59%, SP — 70% (LR+ =2,0, LR- =0,6); for the Jenni's criterion, SN — 67%, SP — 60% (LR+ =1,7, LR- =0,6); for the Stollberger's criterion SN — 78%, SP — 30% (LR+ =1,1, LR- =0,7); for the PLdiast criterion, SN — 33%, SP — 60% (LR+ =0,7, LR- =1,3); for PLsist criterion, SN — 59%, SP — 60% (LR+ =1,5, LR- =0,7); for ALdiast criterion, SN — 41%, SP — 80% (LR+ =2,0, LR- =0,7); for ALsist criterion, SN — 67%, SP — 90% (LR+ =6,7, LR- =0,4). Using ROC analysis with NC/C ratio of 2,3 for the ALsyst criterion, SN was 62%, SP — 92%; with NC/C ratio of 2,2 for PLsyst criteria in a posterolateral view in systole, SN — 62%, SP — 83%; with NC/C ratio of 2,1 for ALdiast criterion in an anterolateral view in diastole, SN — 54%, SP — 88%; with NC/C ratio of 2,1 for PLdiast criterion in a posterolateral view in diastole, SN — 46%, SP — 96%.Conclusion. Standard echocardiographic criteria are characterized by moderate sensitivity and low specificity. To improve the diagnostic accuracy of LVNC, the combined use of modified echocardiographic criteria is possible. As a screening of LVNC, using NC/C of 2,2 for the PLsist and NC/C of 2,3 for the PLsist to improve the specificity of the study should be useful.

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“…Left ventricular (LV) non-compaction (LVNC) is a rare cardiomyopathy due to arrest of the normal maturation process of the myocardium ( 1 – 3 ). It is characterized by prominent LV trabecularization with deep intratrabecular recesses proceeding into progressive systolic and diastolic dysfunction, conduction abnormalities, and thromboembolic events.…”

Section: Introductionmentioning

confidence: 99%

Tricuspid Annular Abnormalities in Isolated Left Ventricular Non-compaction—Insights From the Three-dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study

Nemes

Rácz

Kormányos

2022

Front. Cardiovasc. Med.

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IntroductionProminent trabecular left ventricular (LV) meshwork and deep intertrabecular LV recesses are featuring LV non-compaction (LVNC). The aim of this study was to evaluate tricuspid annular (TA) morphological and functional abnormalities by three-dimensional speckle-tracking echocardiography (3DSTE) in patients with LVNC without right ventricular (RV) involvement.Materials and MethodsThis study consisted of 21 patients with isolated LVNC, from which 6 cases were excluded due to inferior image quality. The remaining patient group consisted of 15 subjects with a mean age of 52.1 ± 11.4 years (9 males). LVNC was defined according to the Jenni's criteria. Their results were compared to 21 age- and gender-matched healthy controls (mean age: 52.4 ± 3.9 years, 14 males). Complete routine 2-dimensional Doppler echocardiographic examination was performed in all the patients with isolated LVNC and healthy controls. End-systolic and end-diastolic TA dimensions were assessed on selected planes derived from full-volume 3D echocardiographic datasets during 3DSTE.ResultsPatients with isolated LVNC showed significantly dilated end-systolic and end-diastolic TA diameter and area, which were accompanied with preserved TA functional properties and associated with right atrial (RA) volumes. TA plane systolic excursion (TAPSE) showed mild correlations with TA fractional area change (TAFAC) and TA fractional shortening (TAFS). No correlations could be demonstrated between TAPSE and TA morphological features. Extent of LVNC did not correlate with any echocardiographic parameters.ConclusionTA is dilated with preserved sphincter-like function in patients with isolated LVNC. Longitudinal (TAPSE) and sphincter-like (TAFAC and TAFS) TA movements correlate with each other. TA dilation is associated with an increased RA volumes respecting cardiac cycle.

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The role of multimodality imaging in the diagnosis of left ventricular noncompaction

Cited by 9 publications

References 86 publications

Magnetic resonance diagnostic criteria of non-compaction cardiomyopathy: new diagnostic criteria still needed?

Magnetic resonance diagnostic criteria of non-compaction cardiomyopathy: new diagnostic criteria still needed?

Diagnostic value of standard and modified echocardiographic criteria for left ventricular noncompaction

Tricuspid Annular Abnormalities in Isolated Left Ventricular Non-compaction—Insights From the Three-dimensional Speckle-Tracking Echocardiographic MAGYAR-Path Study

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