The role of mutagenicity testing in the ecotoxicological evaluation of industrial discharges into the aquatic environment

Raat, W.K. de; Hanstveit, A.O.; Kreuk, J.F. de

doi:10.1016/0278-6915(85)90217-0

Cited by 31 publications

(14 citation statements)

References 29 publications

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“…In fact, effluents from inorganic and organic chemical plants, textile plants, pulp and paper mills, metallurgical plants, and petroleum refineries have been shown to contain genotoxic compounds, some of which have been identified as potent mutagens, teratogens, and carcinogens (Houk, 1992). Since it has been argued that genotoxic chemicals have no real "safe exposure level," their presence in the environment is certainly cause €or concern (Brandes et al, 1985;de Raat et al, 1985). Consequently, the inclusion of genotoxicity tests in ecotoxicological studies is fully warranted (de Raat et al, 1990;Costan et al, 1993; U.S. Environmental Protection Agency (EPA), 1991).…”

Section: Ntro Du Ct 1 0 Nmentioning

confidence: 98%

Detecting genotoxic activity in industrial effluents using the SOS Chromotest microplate assay

Legault

Blaise

Trottier

et al. 1996

Environ. Toxicol. Water Qual.

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Section: Ntro Du Ct 1 0 Nmentioning

confidence: 98%

Detecting genotoxic activity in industrial effluents using the SOS Chromotest microplate assay

Legault

Blaise

Trottier

et al. 1996

Environ. Toxicol. Water Qual.

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“…Although the SOS Chromotest did not generate high TUs in comparison with the other bioassays (algal test and sublethal microinvertebrate test in particular), it did reveal genotoxic activity in 11 of the 15 effluents before and after biodegradability testing (Table 111). Crucial to any PEEP index, however, is the inclusion of a genotoxicity screening test to monitor this specific type of ecotoxic effect now well confirmed in many types of industrial effluents (Somani et a1 ., 1980;de Raat et al, 1985;McGeorge et al, 1985;Nestmann, 1985;Houk and Claxton, 1986).…”

Section: Peep Characteristics Of the Pulp And Paper Sectormentioning

confidence: 99%

Potential ecotoxic effects probe (PEEP): A novel index to assess and compare the toxic potential of industrial effluents

Costan

Bermingham

Blaise

et al. 1993

Environ. Toxicol. Water Qual.

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An index allowing the assessment and comparison of the toxic potential of industrial effluents is described. Integrating the results of practical small‐scale screening bioassays (Photobacterium phosphoreum Microtox® test. Selenastrum capricornutum growth inhibition microtest, Ceriodaphnia dubia lethality and reproduction inhibition tests, Escherichia coli genotoxicity SOS Chromotest), this index takes into account persistence of toxicity, (multi) specificity of toxic impact, as well as effluent flow. The resulting Potential Ecotoxic Effects Probe (PEEP) index number is reflected by a log10 value that varies from 0 to infinity but normally will not surpass a value of 10. The structure of the mathematical formula generating PEEP values is simple and “user friendly” in that it can accommodate numbers and types of bioassays to fit particular needs. Thirty‐seven effluents from 8 industrial sectors (pulp and paper, petroleum refining, inorganic/organic chemical production, mining, metallurgy, metal plating, textile production) were appraised and compared with the proposed PEEP scale. The pulp and paper sector effluents (n = 15) markedly stood out from the others owing to their greater toxicity and higher discharge volume, with reported PEEP values lying between 4.4 and 7.5. For most of these effluents, toxicity was found to be persistent, multitrophic (i.e., affecting our bacterial, algal, and crustacean bioindicators), and it expressed itself at all levels of assessment (i.e., lethal, acute sublethal, chronic sublethal, and genotoxic levels). The usefulness of the PEEP index in the environmental management of industrial effluent toxicity is discussed herein. © 1993 John Wiley & Sons, Inc.

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“…The gas-phase aldehydes, formaldehyde, acetaldehye, and acrolein are the major aldehydes of interest with respect to health effects (68). These aldehydes are reactive electrophiles that form adducts with DNA and proteins.…”

Section: Genotoxic Compounds Identified In Ambient Airmentioning

confidence: 99%

“…This points to another role they may play. If ecotoxicologically relevant effects can be attributed to the presence of a mutagen, studies on its fate in the environment or its identity can be guided by the effect itself (68).…”

Section: Arguments For the Use Of Mutagenicity As A Criterion In Ecotmentioning

confidence: 99%

“…The method has also been used to assess BaP/PAH exposure of foundry workers, coke oven workers, and roofers (33,34,36,69). Some investigators have related adducts in placenta and lung measured by 32 P-postlabeling to cigarette smoking (20,68); others have not seen smoker/nonsmoker differences in bone marrow, WBC, or buccal mucosa (16,67). While the method produces images that are considered an idiosyncratic "fingerprint" of the exposure, researchers involved with developing this assay have faced difficulties in identifying the adducts formed.…”

Section: Markers Of Biologically Effective Dosementioning

confidence: 99%

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Genetic Toxicology of Complex Mixtures

Waters¹,

Daniel²,

Lewtas³

et al. 1990

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A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. All rights reservedNo part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher FOREWORD Contained in this volume are the proceedings of the international conference on the "Genetic Toxicology of Complex Mixtures," held from July 4-7, 1989, in Washington, DC. This meeting was a satellite of the "Fifth International Conference on Environmental Mutagens" and the seventh in a biennial series of conferences on "Short-term Bioassays in the Analysis of Complex Environmental Mixtures."Our central objective in calling together key researchers from around the world was to extend our knowledge of the application of the methods of genetic toxicology and analytical chemistry in the evaluation of chemical mixtures as they exist in the environment. This conference emphasized the study of genotoxicants in air and water, and the assessment of human exposure and cancer risk. The latest strategies and methodologies for biomonitoring of genotoxicants (including transformation products) were described in the context of the ambient environment. Source characterization and source apportionment were discussed as an aid to understanding the origin and relative contribution of various kinds of complex mixtures to the ambient environment. Similarly, investigations of genotoxicants found in the indoor environment (sidestream cigarette smoke) and in drinking water (chlorohydroxyfuranones) were given special attention in terms of their potential health impacts. New molecular techniques were described to enable more precise quantitation of internal dose and doseto-target tissues.The emphasis of presentations on exposures/effects assessment was on integrated quantitative evaluation of human exposure and potential health effects. It is clear that the sophistication of complex mixture research technologies has increased dramatically since the first conference in 1978 with the application of state-of-the-art genetic and molecular methods. It is now apparent that interdisciplinary approaches are essential in order to assess the contribution of mixtures of genotoxic agents in the environment to total human exposure and potential cancer risk.We are indebted to the speakers and chairpersons who presented their data at the meeting and in the excellent chapters that follow.

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The role of mutagenicity testing in the ecotoxicological evaluation of industrial discharges into the aquatic environment

Cited by 31 publications

References 29 publications

Detecting genotoxic activity in industrial effluents using the SOS Chromotest microplate assay

Detecting genotoxic activity in industrial effluents using the SOS Chromotest microplate assay

Potential ecotoxic effects probe (PEEP): A novel index to assess and compare the toxic potential of industrial effluents

Genetic Toxicology of Complex Mixtures

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