The role of mycotoxins in the human exposome: Application of mycotoxin biomarkers in exposome-health studies

Marı́n, Sonia; Cano-Sancho, Germán; Sanchis, Vicente; Ramos, Antonio J.

doi:10.1016/j.fct.2018.09.039

Cited by 44 publications

(40 citation statements)

References 123 publications

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“…The eradication of OTA from the food chain is very difficult due to the high thermal stability (Duarte, Pena, & Lino, ). Its subchronic and chronic toxicity to humans and to several animal species, such as nephrotoxicity, neurotoxicity, teratogenicity, immunotoxicity, mutagenicity, and hepatotoxicity is well known (Marín, Cano‐Sancho, Sanchis, & Ramos, ; Pfohl‐Leszkowicz & Manderville, ). The kidney is the target organ of OTA in human and animals (Damiano et al, ; Limonciel & Jennings, ; Malir, Ostry, Pfohl‐Leszkowicz, Malir, & Toman, ; Pfohl‐Leszkowicz, Petkova‐Bocharova, Chernozemsky, & Castegnaro, ).…”

Section: Introductionmentioning

confidence: 99%

Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats

Damiano¹,

Iovane

Squillacioti³

et al. 2020

Journal Cellular Physiology

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In this work, we investigated the effects of red orange and lemon extract (RLE) on ochratoxin A (OTA)‐induced nephrotoxicity. In particular, we analyzed the change in renal function and oxidative stress in Sprague–Dawley rats treated with OTA (0.5 mg/kg body weight, b.w.) and with RLE (90 mg/kg b.w.) by oral administration. After OTA treatment, we found alterations of biochemical and oxidative stress parameters in the kidney, related to a severe decrease of glomerular filtration rate. The RLE treatment normalized the activity of antioxidant enzymes and prevented the glomerular hyperfiltration. Histopathological examinations revealed glomerular damages and kidney cortex fibrosis in OTA‐rats, while we observed less severe fibrosis in OTA plus RLE group. Then, we demonstrated that oxidative stress could be the cause of OTA renal injury and that RLE reduces this effect.

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Section: Introductionmentioning

confidence: 99%

Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats

Damiano¹,

Iovane

Squillacioti³

et al. 2020

Journal Cellular Physiology

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“…OTA is generally found in all types of cereals and derived products, but also in coffee, cocoa, grapes, soy, spices, legumes, nuts, licorice, wine, and beer [2][3][4]. OTA is often the cause of chronic toxicity, due to the prolonged intake of its small amounts, and manifests itself with carcinogenic, genotoxic, teratogenic, nephrotoxic and immunosuppressive effects [5][6][7] both on humans and numerous animal species. Previous studies have found that its presence in food for human use can induce chronic kidney diseases, such as Endemic Balkan Nephropathy which leads, in a period of 6-10 years, to irreversible renal failure [8,9].…”

Section: Introductionmentioning

confidence: 99%

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats

et al. 2020

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Ochratoxin A (OTA) is a powerful nephrotoxin and the severity of its damage to kidneys depends on both the dose and duration of exposure. According to the scientific data currently available, the mechanism of action still is not completely clarified, but it is supposed that oxidative stress is responsible for OTA-induced nephrotoxicity. Bioactive compound use has emerged as a potential approach to reduce chronic renal failure. Therefore, curcumin (CURC), due to its therapeutic effects, has been chosen for our study to reduce the toxic renal effects induced by OTA. CURC effects are examined in Sprague Dawley rats treated with CURC (100 mg/kg), alone or in combination with OTA (0.5 mg/kg), by gavage daily for 14 days. The end result of the experiment finds rats treated with OTA show alterations in biochemical and oxidative stress parameters in the kidney, related to a decrease in the Glomerular Filtration Rate (GFR). Conversely, the administration of CURC attenuates oxidative stress and prevents glomerular hyperfiltration versus the OTA group. Furthermore, kidney histological tests show a reduction in glomerular and tubular damage, inflammation and tubulointerstitial fibrosis. This study shows that CURC can mitigate OTA–induced oxidative damage in the kidneys of rats.

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“…Their occurrence and concentrations vary considerably among foods due to factors such as crop susceptibility, climate change, storage and transportation conditions, as well as sanitary standards [3,4]. Mycotoxins are hepatotoxic, nephrotoxic, teratogenic, carcinogenic, cytotoxic, immunosuppressive, inflammatory, neurotoxic, and estrogenic, posing diverse health hazards to humans and animals [5][6][7][8]. In particular, fumonisins (FBs) and ochratoxin a (OTA) have been classified as possible human carcinogens (Group 2B).…”

Section: Introductionmentioning

confidence: 99%

Development of a Sensitive and Reliable UHPLC-MS/MS Method for the Determination of Multiple Urinary Biomarkers of Mycotoxin Exposure

Liu

Zhao

et al. 2020

Toxins

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A variety of mycotoxins from different sources frequently contaminate farm products, presenting a potential toxicological concern for animals and human. Mycotoxin exposure has been the focus of attention for governments around the world. To date, biomarkers are used to monitor mycotoxin exposure and promote new understanding of their role in chronic diseases. The goal of this research was to develop and validate a sensitive UHPLC-MS/MS method using isotopically-labeled internal standards suitable for accurate determination of 18 mycotoxin biomarkers, including fumonisins, ochratoxins, Alternaria and emerging Fusarium mycotoxins (fumonisin B1, B2, and B3, hydrolyzed fumonisin B1 and B2, ochratoxin A, B, and alpha, alternariol, alternariol monomethyl ether, altenuene, tentoxin, tenuazonic acid, beauvericin, enniatin A, A1, B, and B1) in human urine. After enzymatic digestion with β-glucuronidase, human urine samples were cleaned up using HLB solid phase extraction cartridges prior to instrument analysis. The multi-mycotoxin and analyte-specific method was validated in-house, providing satisfactory results. The method provided good linearity in the tested concentration range (from LOQ up to 25–500 ng/mL for different analytes), with R2 from 0.997 to 0.999. The limits of quantitation varied from 0.0002 to 0.5 ng/mL for all analytes in urine. The recoveries for spiked samples were between 74.0% and 133%, with intra-day precision of 0.5%–8.7% and inter-day precision of 2.4%–13.4%. This method was applied to 60 urine samples collected from healthy volunteers in Beijing, and 10 biomarkers were found. At least one biomarker was found in all but one of the samples. The high sensitivity and accuracy of this method make it practical for human biomonitoring and mycotoxin exposure assessment.

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The role of mycotoxins in the human exposome: Application of mycotoxin biomarkers in exposome-health studies

Abstract: Està subjecte a una llicència de Reconeixement-NoComercial-SenseObraDerivada 4.0 de Creative Commons

Cited by 44 publications

References 123 publications

Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats

Red orange and lemon extract prevents the renal toxicity induced by ochratoxin A in rats

Effects of Curcumin on the Renal Toxicity Induced by Ochratoxin A in Rats

Development of a Sensitive and Reliable UHPLC-MS/MS Method for the Determination of Multiple Urinary Biomarkers of Mycotoxin Exposure

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