The role of myocardial edema in the left ventricular diastolic stiffness

Pogátsa, G; E, Dubecz; Gábor, G

doi:10.1007/bf01906451

Cited by 56 publications

(24 citation statements)

References 9 publications

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“…On the other hand, myocardial oedema do not develop in diabetic animals in the nonischaemic part of myocardium. One hypothesis might be that myocardial oedema may be a consequence of enhanced coronary flow (20), and vasodilatation is reduced in coronary arterial bed of diabetic animals in such an earlier period, when vascular atherosclerosis or microangiopathy are certainly absent (18). The model for myocardial ischaemia used in this study was an acute coronary artery occlusion followed by norepinephrine infusion.…”

Section: Discussionmentioning

confidence: 99%

“…These changes indicate that during myocardial ischaemia enhanced diastolic stiffness of the global left ventricular wall occurs. Recently, it has been shown that enhanced coronary blood flow enhances diastolic ventricular stiffness and induces myocardial oedema during cardiopulmonary bypass (20). As demonstrated before (18), in healthy animals norepinephrine infusion after the occlusion of left anterior descending coronary artery caused oedema in the non-ischaemic part of myocardium.…”

Section: Introductionmentioning

confidence: 99%

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Effects of coronary occlusion and norepinephrine on the myocardium of alloxan-diabetic dogs

Palik¹,

Koltai²,

Kolonics³

et al. 1982

Basic Res Cardiol

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The aim of this study was to clarify the role of altered diabetic vascular reactivity in ischaemic heart disease. In diabetic condition, the necrotic area of myocardial infarction was significantly extended and myocardial oedema failed to develop after administration of norepinephrine 2 or 48 hours after ligation of the left anterior descending coronary artery. In metabolically healthy dogs the necrotic area of myocardial infarction was considerably smaller and an increase in myocardial water content, in myocardial thiocyanate space, in microscopically demonstrable permeability and in diastolic stiffness of left ventricular wall occurred when norepinephrine was administered 2 or 48 hours after coronary infarction. A close correlation was demonstrable between enhanced water content, thiocyanate space and diastolic stiffness in metabolically healthy animals, whereas in diabetic condition diastolic stiffness was primarily increased, and decreased when norepinephrine was infused after coronary ligation. Therefore, the altered vascular reactivity in diabetes is supposed to be responsible for the lack of oedema in the nonischaemic part of myocardium after norepinephrine infusion as well as for the size and severity of myocardial infarction.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of coronary occlusion and norepinephrine on the myocardium of alloxan-diabetic dogs

Palik¹,

Koltai²,

Kolonics³

et al. 1982

Basic Res Cardiol

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“…The presence of myocardial edema increases the stiffness and decreases the compliance of the LV [30,31]. In addition, a mere 3.5% increase in myocardial water content has been reported to result in the reduction of the cardiac output by 40% [32].…”

Section: Myocardial Edemamentioning

confidence: 99%

T2-weighted cardiovascular magnetic resonance in acute cardiac disease

Eitel

Friedrich

2011

Journal of Cardiovascular Magnetic Resonance

207

139

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Cardiovascular magnetic resonance (CMR) using T2-weighted sequences can visualize myocardial edema. When compared to previous protocols, newer pulse sequences with substantially improved image quality have increased its clinical utility. The assessment of myocardial edema provides useful incremental diagnostic and prognostic information in a variety of clinical settings associated with acute myocardial injury. In patients with acute chest pain, T2-weighted CMR is able to identify acute or recent myocardial ischemic injury and has been employed to distinguish acute coronary syndrome (ACS) from non-ACS as well as acute from chronic myocardial infarction.T2-weighted CMR can also be used to determine the area at risk in reperfused and non-reperfused infarction. When combined with contrast-enhanced imaging, the salvaged area and thus the success of early coronary revascularization can be quantified. Strong evidence for the prognostic value of myocardial salvage has enabled its use as a primary endpoint in clinical trials. The present article reviews the current evidence and clinical applications for T2-weighted CMR in acute cardiac disease and gives an outlook on future developments."The principle of all things is water"Thales of Miletus (624 BC - 546 BC)

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“…Myocardial oedema has previously been shown to be associated with changes in myocardial function, 3 although in some of these studies the methods used to produce oedema (e.g., adrninistration of norepinephrine) might be expected also to cause myocardial damage. The state of myocardial hydration is recognized as an important determinant of function, indeed both oedema and dehydration have been shown to have detrimental effects on myocardial function.4 Pog~itsa et al [3][4][5][6][7] studied the effects of myocardial water content on left ventricular stiffness, but the changes in water content were produced by methods (e.g., norepinephrine) which might also cause tissue damage. They employed quite different methods to induce dehydration or oedema The cause of myocardial oedema during cardioplegic arrest is not limited to an osmotic effect of the solution, but may also result from the ischaemic condition of the myocardium.…”

Section: Discussionmentioning

confidence: 99%