The Role of Myocardial Perfusion Gated SPECT Study in Women with Coronary Artery Disease: A Correlative Study

Akalın, Erdal; Yaylalı, Olga; Kıraç, Fatma Suna; Yüksel, Doğangün; Kılıç, Mustafa

doi:10.4274/mirt.359

Cited by 7 publications

(6 citation statements)

References 26 publications

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“…At 30 min after the intravenous injection, the patients were fed a high-fat meal, and 1 h later an image was obtained. The same collection method was used as that for stress imaging (7). …”

Section: Methodsmentioning

confidence: 99%

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Adenosine triphosphate stress 99mTc-methoxyisobutylisonitrile gated myocardial perfusion imaging efficacy in diagnosing stent restenosis following coronary stent implantation

Peng-fei

Song

et al. 2016

Experimental and Therapeutic Medicine

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Coronary stent restenosis rate following implantation is considerably high. The adenosine stress gated myocardial perfusion imaging (G-MPI) method has been widely used in the diagnosis, risk stratification and prognosis evaluation of coronary heart disease; however, the high cost of adenosine limits its clinical application. The aim of the present study was to investigate the efficacy of adenosine triphosphate (ATP) stress 99mTc-methoxyisobutylisonitrile (99mTc-MIBI) G-MPI for diagnosis in-stent restenosis following coronary stent implantation. Data from 66 patients with typical angina pectoris symptoms who had undergone percutaneous coronary stent implantation >3 months prior to participation in the study were analyzed. All the patients underwent ATP stress 99mTc-MIBI G-MPI and coronary artery angiography as the criterion diagnostic standard within 1 month. The sensitivity, specificity, and accuracy of ATP stress 99mTc-MIBI G-MPI in the assessment of in-stent restenosis were calculated. In addition, Fisher's exact probability methods were used to compare differences between experimental groups. Among 66 patients with a total of 99 implanted coronary arterial branches, 39 patients (59%) with 45 coronary arteries (45%) presented in-stent restenosis. The diagnostic sensitivity, specificity, accuracy, positive predictive and negative predictive value of ATP stress 99mTc-MIBI G-MPI for assessing stent restenosis in all patients were 85, 89, 86, 92 and 80%, respectively. Similarly, these values in patients with myocardial infarction were 79, 88, 83, 88 and 78%, respectively, while in patients without myocardial infarction the values were 90, 91, 90, 95 and 83%, respectively. Therefore, the diagnostic efficacy of ATP stress 99mTc-MIBI G-MPI in patients without myocardial infarction was higher compared with those with myocardial infarction; however, no significant difference was observed between the two groups. Furthermore, the sensitivity, specificity and accuracy for diagnosing LAD stent restenosis were higher compared with LCX and RCA stent restenosis, but with no significant differences observed (P>0.05). The present results indicated that ATP stress 99mTc-MIBI G-MPI had a high clinical application value for diagnosing in-stent restenosis following coronary stent implantation as a non-invasive examination tool, with the advantages of safety and low cost.

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“…At 30 min after the intravenous injection, the patients were fed a high-fat meal, and 1 h later an image was obtained. The same collection method was used as that for stress imaging (7). …”

Section: Methodsmentioning

confidence: 99%

“…In addition, G-MPI is a simultaneous measurement tool for cardiac function parameters, namely left ventricular ejection fraction (LVEF) and ventricular wall motion (5–7). Adenosine stress G-MPI has been widely used in the diagnosis, risk stratification, and prognosis evaluation of CHD (8,9).…”

Section: Introductionmentioning

confidence: 99%

Adenosine triphosphate stress 99mTc-methoxyisobutylisonitrile gated myocardial perfusion imaging efficacy in diagnosing stent restenosis following coronary stent implantation

Peng-fei

Song

et al. 2016

Experimental and Therapeutic Medicine

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“…Coronary diameter stenosis of > 50 % in coronary angiography was considered as significant (10, 11). The number of coronary arteries with significant stenosis, the localization of stenosis and the maximal percentages of stenosis were determined.…”

Section: Methodsmentioning

confidence: 99%

Comparison of the Efficacy of Conventional Echocardiographic Parameters in the Diagnosis of Significant Coronary Artery Stenosis

Xiao

Yang

2014

Iran J Radiol

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Background:For diagnosis of significant coronary artery stenosis, the most accurate parameter among the conventional echocardiographic parameters remains unknown.Objectives:To assess the diagnostic efficacy of conventional echocardiographic parameters in the diagnosis of significant coronary artery stenosis and their correlation with the percentage of stenosis considering conventional coronary angiography as gold standard.Patients and Methods:Seventy eight individuals were included in the study. The three echocardiographic parameters including the coronary sinus flow [flow (mL/minute)], the global left ventricular perfusion by dividing the coronary sinus flow by left ventricular mass [flow/LVM (mL/minute)] and the difference between the left ventricular mass at end diastole and peak systole using area-length calculation methods [LV (d-s) mass A-L] were assessed using receiver operating characteristic (ROC) analysis for their accuracy to distinguish between normal subjects and patients with significant (> 50%) coronary artery disease (CAD).Results:Flow (mL/minute), flow/LVM (mL/minuteg) and LV (d-s) mass A-L all correlated significantly with the percentage of stenosis (r = -0.64, P < 0.001; r = -0.47, P < 0.001; r = -0.56, P < 0.001, respectively). With the use of the percentage of stenosis > 50% as the criteria to distinguish patients with or without CAD, the areas under the ROC curve for flow (mL/minute) were 0.75, while they were 0.57 for flow/LVM (mL/minuteg) and 0.59 for LV (d-s) mass A-L. The percentage of stenosis > 70% was best detected by coronary sinus flow < 198 mL/minute (sensitivity, 81.35%; specificity, 70.37%; positive predictive value, 63.63%; negative predictive value, 86.36% and accuracy, 75%; P < 0.001).Conclusions:The coronary sinus flow per minute is the most accurate parameter among the three echocardiographic parameters mentioned above for the assessment of significant stenosis of the coronary artery.

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“…SPECT imaging, mostly apply simultaneously with gated, is preferably performed in daily practice because of its high sensitivity, specificity, diagnostic accuracy and reader’s confidence in the interpretation of MPS SPECT results. Gated MPS helps in defining the suspected artifacts, risk stratification of patients with known or suspected CAD, myocardial viability, and enhanced detection of multivessels disease ( 3 ). Finally, high-sensitivity dedicated cardiac camera systems aid in injecting lower doses for MPS SPECT with an effective radiation dose of less than 1 mSv without significant loss of accuracy ( 4 ).…”

mentioning

confidence: 99%

Noninvasive cardiac imaging for the diagnosis of coronary artery disease in women

Kıraç¹

2015

Anatol J Cardiol

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The Role of Myocardial Perfusion Gated SPECT Study in Women with Coronary Artery Disease: A Correlative Study

Cited by 7 publications

References 26 publications

Adenosine triphosphate stress 99mTc-methoxyisobutylisonitrile gated myocardial perfusion imaging efficacy in diagnosing stent restenosis following coronary stent implantation

Adenosine triphosphate stress 99mTc-methoxyisobutylisonitrile gated myocardial perfusion imaging efficacy in diagnosing stent restenosis following coronary stent implantation

Comparison of the Efficacy of Conventional Echocardiographic Parameters in the Diagnosis of Significant Coronary Artery Stenosis

Noninvasive cardiac imaging for the diagnosis of coronary artery disease in women

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