The role of N terminal pro-brain natriuretic peptide in the evaluation of left ventricular diastolic dysfunction: correlation with echocardiographic indexes in hypertensive patients

Ceyhan, Ceyhun; Ünal, Selim; Yenisey, Çiğdem; Tekten, Tarkan; Ceyhan, F. Banu Öztürk

doi:10.1007/s10554-007-9256-2

Cited by 28 publications

(19 citation statements)

References 27 publications

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“…Therefore, this parameter is often used for assessing heart failure based on various heart diseases. Several studies reported that the plasma BNP level correlated with the LV diastolic function rather than LVEF (27,28). We confirmed the clinical usefulness of the E/e= by examining its relationship with the plasma BNP level.…”

Section: The Relationship Between E/e= and The Plasma Bnpsupporting

confidence: 78%

Clinical Utility of Single-Beat E/e′ Obtained by Simultaneous Recording of Flow and Tissue Doppler Velocities in Atrial Fibrillation With Preserved Systolic Function

Kusunose

Yamada

Nishio

et al. 2009

JACC: Cardiovascular Imaging

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The single-beat lateral E/e' correlated with plasma BNP level and PCWP in AF patients with preserved systolic function. In addition, the single-beat lateral E/e' (>or=11) was a good predictor of elevated PCWP (>or=15 mm Hg). Dual Doppler echocardiography offers an advantage of providing the single-beat lateral E/e' correctly even in AF patients, for the evaluation of left ventricular diastolic function.

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Section: The Relationship Between E/e= and The Plasma Bnpsupporting

confidence: 78%

Clinical Utility of Single-Beat E/e′ Obtained by Simultaneous Recording of Flow and Tissue Doppler Velocities in Atrial Fibrillation With Preserved Systolic Function

Kusunose

Yamada

Nishio

et al. 2009

JACC: Cardiovascular Imaging

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“…However, the indices evaluated on echocardiography in this study are correlated with the cardiac function in patients with hypertension 43) . The impact of the activation of innate cardiac immunity on the long-term outcomes in in vivo models of hypertrophy and remodeling remains unclear, with conflicting results as to whether it is beneficial or detrimental 11) .…”

Section: Discussionmentioning

confidence: 86%

Angiotensin Ⅱ Activates MCP-1 and Induces Cardiac Hypertrophy and Dysfunction via Toll-like Receptor 4

Matsuda

Umemoto

Yoshimura

et al. 2015

J Atheroscler Thromb

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Aim Angiotensin II (AngII) produces reactive oxygen species (ROS), thus contributing to the development of cardiac hypertrophy and subsequent heart failure, and stimulates the expression of monocyte chemoattractant protein-1 (MCP-1). In addition, Toll-like receptor 4 (TLR4) is involved in the upregulation of MCP-1. In order to clarify whether TLR4 is involved in the onset of cardiac dysfunction caused by AngII stimulation, we investigated the effects of TLR4 on oxidative stress, the MCP-1 expression and cardiac dysfunction in mice with AngII-induced hypertension. Methods TLR4-deficient (Tlr4lPS-d) and wild-type (WT) mice were randomized into groups treated with AngII, norepinephrine (NE) or a subdepressor dose of the AngII receptor blocker irbesartan (IRB) and Angll for two weeks. Results AngII and NE similarly increased systolic blood pressure in all drug-treated groups compared to that observed in the control group among both WT and T1r4lps-d mice (p< 0.05). In the WT mice, AngII induced cardiac hypertrophy as well as vascular remodeling and perivascular fibrosis of the intramyocardial arteries and monocyte/macrophage infiltration in the heart (P<0.05). Furthermore, AngII treatment decreased the left ventricular diastolic function and resulted in a greater left ventricular end-systolic dimension (P<0.05) in addition to producing a five-fold increase in the NADPH oxidase activity, ROS content and MCP-1 expression (P<0.05). In contrast, the Tlr4lps-d mice showed little effects of AngII on these indices. In the WT mice, IRB treatment reversed these changes compared to that seen in the mice treated with AngII alone. NE produced little effect on any of the indices in either the WT or T1r4lps-d mice. Conclusions TLR4 may be involved in the processes underlying the increased oxidative stress, selectively activated MCP-1 expression and cardiac hypertrophy and dysfunction seen in cases of AngII-induced hypertension.

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“…The ratio of transmitral E wave velocity to myocardial E 0 velocity measured by DTI, E/E 0 , has been validated and widely accepted as a noninvasive surrogate measure of LV filling pressure in the general population, in patients with hypertension [32], systemic lupus erythematosus [33] as well as in preeclampsia [34]. In addition, it has been suggested to be a useful and more reliable index for evaluating the LV diastolic function than E/A ratio only.…”

Section: Discussionmentioning

confidence: 99%

Assessment of left ventricular structure and function in preeclampsia by echocardiography and cardiovascular biomarkers

Hamad

Larsson

Pernow³

et al. 2009

Journal of Hypertension

139

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The role of N terminal pro-brain natriuretic peptide in the evaluation of left ventricular diastolic dysfunction: correlation with echocardiographic indexes in hypertensive patients

Abstract: The assessment of the blood concentration of NT-proBNP is of potential value for identification of those patients with hypertension to detect early cardiovascular changes, especially LV diastolic dysfunction.

Cited by 28 publications

References 27 publications

Clinical Utility of Single-Beat E/e′ Obtained by Simultaneous Recording of Flow and Tissue Doppler Velocities in Atrial Fibrillation With Preserved Systolic Function

Clinical Utility of Single-Beat E/e′ Obtained by Simultaneous Recording of Flow and Tissue Doppler Velocities in Atrial Fibrillation With Preserved Systolic Function

Angiotensin Ⅱ Activates MCP-1 and Induces Cardiac Hypertrophy and Dysfunction via Toll-like Receptor 4

Assessment of left ventricular structure and function in preeclampsia by echocardiography and cardiovascular biomarkers

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