The Role of N6-Methyladenosine in the Promotion of Hepatoblastoma: A Critical Review

Abstract

Hepatoblastoma (HB) is a rare primary malignancy of the developing fetal liver. Its course is profoundly influenced by genetics, in the context of sporadic mutation or genetic syndromes. Conventionally, subtypes of HB are histologically determined based on the tissue type that is recapitulated by the tumor and the direction of its differentiation. This classification is being reevaluated based on advances on molecular pathology. The therapeutic approach comprises surgical intervention, chemotherapy (in a neoadjuvant or post-operative capacity), and in some cases, liver transplantation. Although diagnostic modalities and treatment options are evolving, some patients experience complications, including relapse, metastatic spread, and suboptimal response to chemotherapy. As yet, there is no consistent framework with which such outcomes can be predicted. N6-methyladenosine (m6A) is an RNA modification with rampant involvement in the normal processing of cell metabolism and neoplasia. It has been observed to impact the development of a variety of cancers via its governance of gene expression. M6A-associated genes appear prominently in HB. Literature data seem to underscore the role of m6A in promotion and clinical course of HB. Illuminating the pathogenetic mechanisms that drive HB are promising additions to the understanding of the clinically aggressive tumor behavior, given its potential to predict disease course and response to therapy. Implicated genes may also act as targets to facilitate the evolving personalized cancer therapy. Here, we explore the role of m6A and its genetic associates in the promotion of HB, and the impact this may have on the management of this neoplastic disease.

Mitochondrial Dysfunction and Induction of Apoptosis in Hepatocellular Carcinoma and Cholangiocarcinoma Cell Lines by Thymoquinone

“…Recently, Jehan et al identified that TQ selectively promotes HCC apoptosis in synergy with the p53 status, which may harbor relevance for most current tumor RNA modification studies [ 119 , 120 ]. In this study, the cytotoxic effects of TQ, alone or in combination with cisplatin and doxorubicin, were investigated in HCC cells.…”

An overview of the effects and mechanisms of m6 A methylation on innate immune cells in sepsis

“…In addition, Weng et al. ( 19 ) have demonstrated that METTL14 and YTHDF1 participate in neurogenesis by promoting protein translation, implying the pivotal role of m 6 A in mRNA translation. All these findings make m 6 A a new target for inhibiting inflammation.…”

“…Another study by Zhang et al (18) has shown that YTHDF1 regulates cell stability by promoting the translation of m 6 A-modified Robo3.1 mRNA. In addition, Weng et al (19) have demonstrated that METTL14 and YTHDF1 participate in neurogenesis by promoting protein translation, implying the pivotal role of m 6 A in mRNA translation. All these findings make m 6 A a new target for inhibiting inflammation.…”

A systematic review on omics data (metagenomics, metatranscriptomics, and metabolomics) in the role of microbiome in gallbladder disease

“…In addition, metatranscriptomic studies focused on RNA sequencing (RNA seq) also allow functional changes to be discovered to decipher what can affect antibiotic resistance gene expression after exposure to antibiotics. They can also study changes in the virulence factors of specific pathogens and epigenomic studies of some neoplastic conditions ( Sharma et al, 2010 ; Korry et al, 2020 ; Auld et al, 2022 ).…”