The role of N6-methyladenosine methylation in environmental exposure-induced health damage

Emerging Role of Environmental Epitranscriptomics and RNA Modifications in Parkinson’s Disease

“…Emerging data from in vitro, rodent, and human exposure studies suggest that, like epigenetic marks, epitranscriptomic marks are also responsive to environmental exposures [12,[15][16][17][18][19]. This rapidly growing body of evidence indicates that a wide range of exposures, including but not limited to polyaromatic hydrocarbons, endocrine disruptors, dioxins, persistent organic pollutants, certain types of pesticides, heavy metals, air pollution, cigarette smoking, and nanoparticles, have been shown to affect RNA modifications and expression of RNA modulators in many types of cells, animal models and human studies.…”

“…Epigenetics, and more recently, the emerging field of epitranscriptomics, have been recognized as potential mediators of the complex relationship between genes, environment and disease because they are sensitive to the environment and regulate gene expression throughout the lifespan (Fig. 1) [8][9][10][11][12][13][14][15][16][17][18][19]. Thus, exploring both epigenetic and epitranscriptomic changes in PD and models of PD-related exposures is a critical and underexplored avenue of research.…”

Association between Dietary Protein Energy Supply Ratio and Obesity in United States Children and Adolescents

“…Over the past 40 years, obesity in children and adolescents has increased at an alarming rate and becoming a rising public health concern [1]. According to the World Obesity Federation's estimation in 2019, it is projected that by 2025, there will be 206 million children with obesity and adolescents aged 5 to 19 [2]. In the United States, as of 2016, 18.4% of children Disclaimer/Publisher's Note: The statements, opinions, and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s).…”