The role of NAD biosynthesis in plant development and stress responses

Hashida, Shin‐nosuke; Takahashi, Hideyuki; Uchimiya, Hirofumi

doi:10.1093/aob/mcp019

Cited by 160 publications

(145 citation statements)

References 44 publications

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“…Down-regulation of AtPARP1 and AtPARP2 causes resistance to a number of abiotic stresses, including heat, cold, and drought (Amor et al, 1998;De Block et al, 2005;Vanderauwera et al, 2007), as does application of PARP inhibitors to plants (De Block et al, 2005). This effect may be mediated directly through PARP targets or could be a consequence of altered NAD metabolism in the plants (Hashida et al, 2009).…”

mentioning

confidence: 99%

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

2009

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RADICAL-INDUCED CELL DEATH1 (RCD1) and SIMILAR TO RCD ONE1 (SRO1) are the only two proteins encoded in the Arabidopsis (Arabidopsis thaliana) genome containing both a putative poly(ADP-ribose) polymerase catalytic domain and a WWE protein-protein interaction domain, although similar proteins have been found in other eukaryotes. Poly(ADP-ribose) polymerases mediate the attachment of ADP-ribose units from donor NAD + molecules to target proteins and have been implicated in a number of processes, including DNA repair, apoptosis, transcription, and chromatin remodeling. We have isolated mutants in both RCD1 and SRO1, rcd1-3 and sro1-1, respectively. rcd1-3 plants display phenotypic defects as reported for previously isolated alleles, most notably reduced stature. In addition, rcd1-3 mutants display a number of additional developmental defects in root architecture and maintenance of reproductive development. While single mutant sro1-1 plants are relatively normal, loss of a single dose of SRO1 in the rcd1-3 background increases the severity of several developmental defects, implying that these genes do share some functions. However, rcd1-3 and sro1-1 mutants behave differently in several developmental events and abiotic stress responses, suggesting that they also have distinct functions. Remarkably, rcd1-3; sro1-1 double mutants display severe defects in embryogenesis and postembryonic development. This study shows that RCD1 and SRO1 are at least partially redundant and that they are essential genes for plant development.

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confidence: 99%

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

2009

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“…It has been reported that the degree of poly ADP ribose (PAR) synthesis by the PAR polymerases (PARP) is increased in proportion to stress severity. 85 PARP reaction consumes NAD and ATP, therefore affecting energy homeostasis. 86 These authors observed that the downregulation of PARP enhanced stress tolerance probably due to a reduced consumption of NAD and ATP.…”

Section: Stress and Energy As A Metabolic Input To The Clockmentioning

confidence: 99%

Abiotic stress and the plant circadian clock

Sanchez

Shin²,

Davis

2011

Plant Signaling & Behavior

120

107

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“…Previous studies have investigated the biological significance of some genes associated with NAD(P)(H) biosynthesis in plants, including NMNAT, AtNIC1, NADK2, and so on (Hashida et al, 2007(Hashida et al, , 2009Wang and Pichersky, 2007). Here, we demonstrate that a mutation in OsNaPRT1, which encodes a NaPRTase capable of converting nicotinate to NaMN in the salvage pathway of NAD biosynthesis, accelerates the progress of leaf senescence in rice.…”

Section: Discussion Mutant Osnaprt1 Disturbs the Nad Salvage Pathwaymentioning

confidence: 73%

“…The amount of NAD(P)(H) should be sufficient for preventing cell death due to NAD depletion in vivo. Therefore, every organism must continuously resynthesize NAD(P)(H) to maintain balance of the internal environment (Hashida et al, 2009).…”

mentioning

confidence: 99%

“…In the salvage pathway, nicotinate mononucleotide (NaMN; an intermediate in the de novo pathway) is formed from nicotinamide (a product of NAD degradation) through two enzymatic steps (Katoh et al, 2006;Wang and Pichersky, 2007). Specifically, nicotinamide is hydrolyzed to nicotinate by nicotinamidase and is converted to NaMN by nicotinate phosphoribosyltransferase (NaPRTase; Wang and Pichersky, 2007;Hashida et al, 2009). NaPRTase is believed to be the rate-limiting enzyme in the NAD salvage pathway (Magni et al, 1999).…”

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confidence: 99%

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Mutation of OsNaPRT1 in the NAD Salvage Pathway Leads to Withered Leaf Tips in Rice

Ren

et al. 2016

Plant Physiol.

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Premature leaf senescence affects plant growth and yield in rice. NAD plays critical roles in cellular redox reactions and remains at a sufficient level in the cell to prevent cell death. Although numerous factors affecting leaf senescence have been identified, few involving NAD biosynthetic pathways have been described for plants. Here, we report the cloning and characterization of Leaf Tip Senescence 1 (LTS1) in rice (Oryza sativa), a recessive mutation in the gene encoding O. sativa nicotinate phosphoribosyltransferase (OsNaPRT1) in the NAD salvage pathway. A point mutation in OsNaPRT1 leads to dwarfism and the withered leaf tip phenotype, and the lts1 mutant displays early leaf senescence compared to the wild type. Leaf nicotinate and nicotinamide contents are elevated in lts1, while NAD levels are reduced. Leaf tissue of lts1 exhibited significant DNA fragmentation and H 2 O 2 accumulation, along with up-regulation of genes associated with senescence. The lts1 mutant also showed reduced expression of SIR2-like genes (OsSRT1 and OsSRT2) and increased acetylation of histone H3K9. Downregulation of OsSRTs induced histone H3K9 acetylation of senescence-related genes. These results suggest that deficiency in the NAD salvage pathway can trigger premature leaf senescence due to transcriptional activation of senescence-related genes.

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The role of NAD biosynthesis in plant development and stress responses

Cited by 160 publications

References 44 publications

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

The Paralogous GenesRADICAL-INDUCED CELL DEATH1andSIMILAR TO RCD ONE1Have Partially Redundant Functions during Arabidopsis Development

Abiotic stress and the plant circadian clock

Mutation of OsNaPRT1 in the NAD Salvage Pathway Leads to Withered Leaf Tips in Rice

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