The role of nanoparticles in the albumin-cytarabine and albumin-methotrexate interactions

Pentak, Danuta; Maciążek-Jurczyk, Małgorzata; Zawada, Zygmunt H.

doi:10.1016/j.msec.2016.12.055

Cited by 13 publications

(9 citation statements)

References 37 publications

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“…However, when the pH value of 0.9% saline decreases from 7.0 to 4.0, the release rate of loaded PTX increases from 37.61 to 65.56% in 96 h, which implies that PTX loaded on CA-CSNPs would have a faster release rate when it is transported to the vicinity of tumor cells because of the slightly acidic environment of tumor cells, which is consistent with the micro acid environment tested in vitro. As can be seen in Table S3, the release kinetics show that PTX release from CA-CSNPs was consistent with the Ritger-Peppas release kinetics (Equation ( 9)), and the drug release factor (n) was 0.32 when the pH value of 0.9% normal saline was 7.0, which suggests that the mechanism of PTX release on CA-CSNPs should be Fick diffusion rather than dissolution desorption [46], and indicates that PTX had already diffused into the carrier interior in the loading process of PTX due to the most amorphous structure of CA-CSNPs. Therefore, once the drug carrier is in the bloodstream, CA-CSNPs will effectively avoid PTX As can be seen in Table S3, the release kinetics show that PTX release from CA-CSNPs was consistent with the Ritger-Peppas release kinetics (Equation ( 9)), and the drug release factor (n) was 0.32 when the pH value of 0.9% normal saline was 7.0, which suggests that the mechanism of PTX release on CA-CSNPs should be Fick diffusion rather than dissolution desorption [46], and indicates that PTX had already diffused into the carrier interior in the loading process of PTX due to the most amorphous structure of CA-CSNPs.…”

Section: Drug Release Analysissupporting

confidence: 66%

“…As can be seen in Table S3, the release kinetics show that PTX release from CA-CSNPs was consistent with the Ritger-Peppas release kinetics (Equation ( 9)), and the drug release factor (n) was 0.32 when the pH value of 0.9% normal saline was 7.0, which suggests that the mechanism of PTX release on CA-CSNPs should be Fick diffusion rather than dissolution desorption [46], and indicates that PTX had already diffused into the carrier interior in the loading process of PTX due to the most amorphous structure of CA-CSNPs. Therefore, once the drug carrier is in the bloodstream, CA-CSNPs will effectively avoid PTX As can be seen in Table S3, the release kinetics show that PTX release from CA-CSNPs was consistent with the Ritger-Peppas release kinetics (Equation ( 9)), and the drug release factor (n) was 0.32 when the pH value of 0.9% normal saline was 7.0, which suggests that the mechanism of PTX release on CA-CSNPs should be Fick diffusion rather than dissolution desorption [46], and indicates that PTX had already diffused into the carrier interior in the loading process of PTX due to the most amorphous structure of CA-CSNPs. Therefore, once the drug carrier is in the bloodstream, CA-CSNPs will effectively avoid PTX binding with blood protein to protect the physiological activity of PTX.…”

Section: Drug Release Analysissupporting

confidence: 66%

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Preparation and Drug-Loading Properties of Amphoteric Cassava Starch Nanoparticles

et al. 2022

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Based on the characteristics of charge reversal around the isoelectric point (pI) of amphoteric starch-containing anionic and cationic groups, amphoteric cassava starch nanoparticles (CA-CANPs) are prepared by a W/O microemulsion crosslinking method using (3-chloro-2-hydroxypropyl) trimethyl ammonium chloride as a cationic reagent and POCl3 as an anionic reagent, and the effects of preparation conditions on the particle size of the CA-CANPs are studied in detail in the present study. CA-CANPs with a smooth surface and an average diameter of 252 nm are successfully prepared at the following optimised conditions: a crosslinking agent amount of 15 wt%, an aqueous starch concentration of 6.0 wt%, an oil–water ratio of 10:1, a total surfactant amount of 0.20 g·mL−1, and a CHPTAC amount of 4.05 wt%. The pH-responsive value of the CA-CANPs can be regulated by adjusting the nitrogen–phosphorus molar ratio in the CA-CANPs. By using CA-CANPs with a pI of 6.89 as drug carriers and the paclitaxel (PTX) as a model drug, the maximum loading rate of 36.14 mg·g−1 is achieved, and the loading process is consistent with the Langmuir isotherm adsorption, with the calculated thermodynamic parameters of ΔH° = −37.91 kJ·mol−1, ΔS° = −10.96 J·mol−1·K−1 and ΔG° < 0. By testing the release rate in vitro, it is noted that the release rates of PTX in a neutral environment (37.6% after 96 h) and a slightly acidic environment (58.65% after 96 h) are quite different, suggesting that the CA-CANPs have the possibility of being a targeted controlled-release carrier with pH responsiveness for antitumor drugs.

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Section: Drug Release Analysissupporting

confidence: 66%

Section: Drug Release Analysissupporting

confidence: 66%

Preparation and Drug-Loading Properties of Amphoteric Cassava Starch Nanoparticles

et al. 2022

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“…The decrease in the degree of encapsulated caffeine with the increase in the caffeine amount bound to protein has also been reported by Y. Guo et al [ 43 ] The calculated degree of encapsulated caffeine in the liposomes was 84.8% (Equation 1), which was high according to the published literature. [ 44 ]…”

Section: Results and Disscussionmentioning

confidence: 99%

Modification of hydrophilic polymer network to design a carrier for a poorly water‐soluble substance

Markovič

Panic

Šešlija

et al. 2020

Polymer Engineering & Sci

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pH sensitive, nontoxic, and biocompatible poly(methacrylic) acid (PMAA) based soft networks have been extensively used in the design of systems for targeted drug delivery. Still, their highly hydrophilic nature limits their potential to be used as a carrier of poorly water-soluble substances. With the aim to overcome this limitation, the present study details a new approach for modification of PMAA based carriers using two amphiphilic components: casein and liposomes. The FTIR analysis revealed structural features of each component as well as the synergetic effect that originated from the formation of specific interactions. Namely, hydrophobic interactions between the poorly watersoluble model drug (caffeine) and casein enabled caffeine encapsulation and controlled release, while addition of liposomes ensured better control of the release rate. The morphological properties of the carriers, swelling behavior, and release kinetics of caffeine were investigated depending on the variable synthesis parameters (neutralization degree of methacrylic acid, concentration of caffeine, presence/absence of liposomes) in two different media simulating the pH environment of human intestines and stomach. The data obtained from in vitro caffeine release were correlated and analyzed in detail using several mathematical models, indicating significant potential of investigated carriers for targeted delivery and controlled release of poorly water-soluble substances.

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“…The REV method was described by Papahadjopoulos [19]. The modification of this method consisted of replacing the ultrasonic dispersion of the aqueous phase in the organic phase with mechanical dispersion that allows complete conversion of the phospholipids to the liposomes [20].…”

Section: Liposome Preparationmentioning

confidence: 99%

The Advances and Challenges of Liposome-Assisted Drug Release in the Presence of Serum Albumin Molecules: The Influence of Surrounding pH

et al. 2022

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The aim of this study is to prepare a liposomal delivery system for 5-methyl-12 (H)-quino[3,4-b]-1,4-benzothiazine chloride (5-MBT) and study the in vitro release characteristics. The release of 5-MBT from a liposomal complex with human serum albumin (HSA) [LDPPC/5-MBT]:HSA was examined using the spectrophotometric method and differential scanning calorimetry (DSC). Electronic paramagnetic resonance was used to assess the influence of the pH of the environment on the conformation of phospholipids, the latter determining the degree of release of the encapsulated compound. The applied mathematical models made it possible to determine the necessary analytical parameters to facilitate the process of potential drug release from liposomes. The complexes formed by liposomal 5-MBT with serum albumin (HSA) particles allowed for the description of the Fick process. The change in the polarity of the phospholipid membrane resulting from the changes in the pH of the surroundings, significantly influenced the percentage of 5-MBT entrapment in the liposomes. It also affected the release percentage.

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The role of nanoparticles in the albumin-cytarabine and albumin-methotrexate interactions

Cited by 13 publications

References 37 publications

Preparation and Drug-Loading Properties of Amphoteric Cassava Starch Nanoparticles

Preparation and Drug-Loading Properties of Amphoteric Cassava Starch Nanoparticles

Modification of hydrophilic polymer network to design a carrier for a poorly water‐soluble substance

The Advances and Challenges of Liposome-Assisted Drug Release in the Presence of Serum Albumin Molecules: The Influence of Surrounding pH

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