The role of nanotechnology in combating biofilm-based antibiotic resistance

Malaekeh‐Nikouei, Bizhan; Bazzaz, Bibi Sedigheh Fazly; Mirhadi, Elaheh; Tajani, Amineh Sadat; Khameneh, Bahman

doi:10.1016/j.jddst.2020.101880

Cited by 78 publications

(65 citation statements)

References 194 publications

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“…One of the main reasons for treatment failure is vaginal biofilm which plays a key role not only in BV pathogenesis but also in its recurrence (Tomás et al., 2020 ). Bacterial biofilms are established when an accumulation of adherent microorganisms occurs on a living surface (Malaekeh-Nikouei et al., 2020 ). The biofilm’s structure avoids the antimicrobial penetration in the matrix as well as the direct contact with the microorganisms.…”

Section: Resultsmentioning

confidence: 99%

“…The antimicrobial agents’ encapsulation into lipid-based carriers has many advantages such as deactivation resistance, as well as reduction of adverse effects and systematic toxicity. Furthermore, the prolonged-release behavior of antibiotics from the lipid nanoformulations was reported in biofilm eradication and improved antibacterial activities (Malaekeh-Nikouei et al., 2020 ). According to several studies, SLNs were found to have potential antibiofilm activity against many types of bacteria (Singh et al., 2014 ; Islan et al., 2016 ; Sharma et al., 2016 ; Akhtari et al., 2020 ).…”

Section: Resultsmentioning

confidence: 99%

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Clinical comparative study of optimized metronidazole loaded lipid nanocarrier vaginal emulgel for management of bacterial vaginosis and its recurrence

et al. 2021

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Clinical comparative study of optimized metronidazole loaded lipid nanocarrier vaginal emulgel for management of bacterial vaginosis and its recurrence

et al. 2021

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“…The nanotechnology-based drug-delivery systems have been shown to enable the slow and controlled release of drugs. Many systems have been generated and are based on different compounds such as lipids and polymers [ 7 , 274 ].…”

Section: Alternative Treatments Of Staphylococcal Biofilmsmentioning

confidence: 99%

Staphylococcal Biofilms: Challenges and Novel Therapeutic Perspectives

et al. 2021

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Staphylococci, like Staphylococcus aureus and S. epidermidis, are common colonizers of the human microbiota. While being harmless in many cases, many virulence factors result in them being opportunistic pathogens and one of the major causes of hospital-acquired infections worldwide. One of these virulence factors is the ability to form biofilms—three-dimensional communities of microorganisms embedded in an extracellular polymeric matrix (EPS). The EPS is composed of polysaccharides, proteins and extracellular DNA, and is finely regulated in response to environmental conditions. This structured environment protects the embedded bacteria from the human immune system and decreases their susceptibility to antimicrobials, making infections caused by staphylococci particularly difficult to treat. With the rise of antibiotic-resistant staphylococci, together with difficulty in removing biofilms, there is a great need for new treatment strategies. The purpose of this review is to provide an overview of our current knowledge of the stages of biofilm development and what difficulties may arise when trying to eradicate staphylococcal biofilms. Furthermore, we look into promising targets and therapeutic methods, including bacteriocins and phage-derived antibiofilm approaches.

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“…While all types of NPs have been intensively studied for drug delivery applications, inorganic NPs provide more suitable features that ensure the protection and bioavailability of the drug with targeted action, limited adverse reactions to the organism, and higher efficiency due to improved drug transport and penetration [ 6 , 25 , 26 ]. Among the envisaged disease treatments, antimicrobial therapies are of considerable importance due to the possibility of developing alternative antimicrobial agents with the ability to destroy or inhibit the growth of antimicrobial-resistant pathogens [ 26 , 27 , 28 , 29 ]. In this regard, inorganic NPs demonstrated increased effectiveness both as nanobiocides due to their intrinsic antimicrobial properties and as nanocarriers for antimicrobial drugs [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Inorganic Nanoparticles and Composite Films for Antimicrobial Therapies

Spirescu

Chircov

Grumezescu

et al. 2021

IJMS

106

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The development of drug-resistant microorganisms has become a critical issue for modern medicine and drug discovery and development with severe socio-economic and ecological implications. Since standard and conventional treatment options are generally inefficient, leading to infection persistence and spreading, novel strategies are fundamentally necessary in order to avoid serious global health problems. In this regard, both metal and metal oxide nanoparticles (NPs) demonstrated increased effectiveness as nanobiocides due to intrinsic antimicrobial properties and as nanocarriers for antimicrobial drugs. Among them, gold, silver, copper, zinc oxide, titanium oxide, magnesium oxide, and iron oxide NPs are the most preferred, owing to their proven antimicrobial mechanisms and bio/cytocompatibility. Furthermore, inorganic NPs can be incorporated or attached to organic/inorganic films, thus broadening their application within implant or catheter coatings and wound dressings. In this context, this paper aims to provide an up-to-date overview of the most recent studies investigating inorganic NPs and their integration into composite films designed for antimicrobial therapies.

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The role of nanotechnology in combating biofilm-based antibiotic resistance

Cited by 78 publications

References 194 publications

Clinical comparative study of optimized metronidazole loaded lipid nanocarrier vaginal emulgel for management of bacterial vaginosis and its recurrence

Clinical comparative study of optimized metronidazole loaded lipid nanocarrier vaginal emulgel for management of bacterial vaginosis and its recurrence

Staphylococcal Biofilms: Challenges and Novel Therapeutic Perspectives

Inorganic Nanoparticles and Composite Films for Antimicrobial Therapies

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