The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment

Zhang, Ye; Dong, Pengbo; Yang, Lu

doi:10.3389/fimmu.2023.1189323

Cited by 6 publications

(4 citation statements)

References 143 publications

(157 reference statements)

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“…The results demonstrate that LCNPs are suitable to deliver highly hydrophobic curcumin to HNSCC cells, independent of their HPV status, and are in line with other studies that reported good uptake of curcumin nanoparticles [38,45]. Based on the enhanced penetration and retention effect, CUR-LCNP could provide suitable accumulation inside solid tumors [46,47].…”

Section: Drug Uptake Studiessupporting

confidence: 89%

Lipid-Coated Polymeric Nanoparticles for the Photodynamic Therapy of Head and Neck Squamous Cell Carcinomas

Roschenko,

Ayoub,

Engelhardt

et al. 2023

Pharmaceutics

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Next to alcohol and tobacco abuse, infection with human papillomaviruses (HPVs) is a major risk factor for developing head and neck squamous cell carcinomas (HNSCCs), leading to 350,000 casualties worldwide each year. Limited therapy options and drug resistance raise the urge for alternative methods such as photodynamic therapy (PDT), a minimally invasive procedure used to treat HNSCC and other cancers. We prepared lipid-coated polymeric nanoparticles encapsulating curcumin as the photosensitizer (CUR-LCNPs). The prepared CUR-LCNPs were in the nanometer range (153.37 ± 1.58 nm) and showed an encapsulation efficiency of 92.69 ± 0.03%. Proper lipid coating was visualized using atomic force microscopy (AFM). The CUR-LCNPs were tested in three HPVpos and three HPVneg HNSCC lines regarding their uptake capabilities and in vitro cell killing capacity, revealing a variable but highly significant tumor cell inhibiting effect in all tested HNSCC cell lines. No significant differences were detected between the HPVpos and HPVneg HNSCC groups (mean IC50: (9.34 ± 4.73 µmol/L vs. 6.88 ± 1.03 µmol/L), suggesting CUR-LCNPs/PDT to be a promising therapeutic option for HNSCC patients independent of their HPV status.

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Section: Drug Uptake Studiessupporting

confidence: 89%

Lipid-Coated Polymeric Nanoparticles for the Photodynamic Therapy of Head and Neck Squamous Cell Carcinomas

Roschenko,

Ayoub,

Engelhardt

et al. 2023

Pharmaceutics

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“…One study [238] showed that MMP3 can be used as a potential biomarker for oral cancer progression. In addition, a recent study [231] found that MMP family expression correlates with the levels of infiltration of six immune cells, B cells, CD8 + T cells, CD4 + T cells, macrophages, neutrophils, and dendritic cells, suggesting that the MMP family may reflect immune status and serve as a prognostic sign in HNSCC. Kudo et al demonstrated that the highly invasive HNSCC cell line MSCC-inv1 significantly overexpresses MMP19 [239].…”

Section: Role Of the Ecm In Hnsccmentioning

confidence: 98%

“…In addition to the above-mentioned function, MMPs destroy the basal membrane and capillary wall and stimulate neoangiogenesis; therefore, these enzymes have a key role in the progression of HNSCC [227][228][229]. A number of studies have demonstrated an increase in MMPs in HNSCC [230,231]. Interestingly, the level of MMP elevation depends on the anatomical localization of squamous cell cancer in the head and neck region.. For example, MMP1 and MMP10 are highly expressed in OSCC [232] and MMP3 expression is elevated in squamous cell carcinoma of the tongue [233].…”

Section: Role Of the Ecm In Hnsccmentioning

confidence: 99%

Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma

Jumaniyazova,

Lokhonina,

Dzhalilova

et al. 2023

JPM

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Head and neck squamous cell cancer (HNSCC) is one of the ten most common malignant neoplasms, characterized by an aggressive course, high recurrence rate, poor response to treatment, and low survival rate. This creates the need for a deeper understanding of the mechanisms of the pathogenesis of this cancer. The tumor microenvironment (TME) of HNSCC consists of stromal and immune cells, blood and lymphatic vessels, and extracellular matrix. It is known that HNSCC is characterized by complex relationships between cancer cells and TME components. TME components and their dynamic interactions with cancer cells enhance tumor adaptation to the environment, which provides the highly aggressive potential of HNSCC and resistance to antitumor therapy. Basic research aimed at studying the role of TME components in HNSCC carcinogenesis may serve as a key to the discovery of both new biomarkers–predictors of prognosis and targets for new antitumor drugs. This review article focuses on the role and interaction with cancer of TME components such as newly formed vessels, cancer-associated fibroblasts, and extracellular matrix.

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“…[15][16][17][18] As we strive to find suitable treatment strategies in conjunction with PD-1/PD-L1 antibodies, our focus has shifted towards an emerging paradigm of targeted therapy using nanomaterials and nanotechnology, the concepts that have garnered significant attention in recent years. [19][20][21] Among these, photothermal therapy (PTT) has gained widespread acclaim as a non-invasive and highly precise cancer management method. PTT utilizes nanomaterials capable of converting light energy into heat, inducing localized hyperthermia and selectively destroying cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Precision USPIO-PEG-SLex Nanotheranostic Agent Targeted Photothermal Therapy for Enhanced Anti-PD-L1 Immunotherapy to Treat Immunotherapy Resistance

Li,

Guo,

et al. 2024

IJN

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Background The anti-Programmed Death-Ligand 1 (termed aPD-L1) immune checkpoint blockade therapy has emerged as a promising treatment approach for various advanced solid tumors. However, the effect of aPD-L1 inhibitors limited by the tumor microenvironment makes most patients exhibit immunotherapy resistance. Methods We conjugated the Sialyl Lewis X with a polyethylene glycol-coated ultrasmall superparamagnetic iron oxide (USPIO-PEG) to form UPS nanoparticles (USPIO-PEG-SLe x , termed UPS). The physicochemical properties of UPS were tested and characterized. Transmission electron microscopy and ICP-OES were used to observe the cellular uptake and targeting ability of UPS. Flow cytometry, mitochondrial membrane potential staining, live-dead staining and scratch assay were used to verify the in vitro photothermal effect of UPS, and the stimulation of UPS on immune-related pathways at the gene level was analyzed by sequencing. Biological safety analysis and pharmacokinetic analysis of UPS were performed. Finally, the amplification effect of UPS-mediated photothermal therapy on aPD-L1-mediated immunotherapy and the corresponding mechanism were studied. Results In vitro experiments showed that UPS had strong photothermal therapy ability and was able to stimulate 5 immune-related pathways. In vivo, when the PTT assisted aPD-L1 treatment, it exhibited a significant increase in CD4 + T cell infiltration by 14.46-fold and CD8 + T cell infiltration by 14.79-fold, along with elevated secretion of tumor necrosis factor-alpha and interferon-gamma, comparing with alone aPD-L1. This PTT assisted aPD-L1 therapy achieved a significant inhibition of both primary tumors and distant tumors compared to the alone aPD-L1, demonstrating a significant difference. Conclusion The nanotheranostic agent UPS has been introduced into immunotherapy, which has effectively broadened its application in biomedicine. This photothermal therapeutic approach of the UPS nanotheranostic agent enhancing the efficacy of aPD-L1 immune checkpoint blockade therapy, can be instructive to address the challenges associated with immunotherapy resistance, thereby offering potential for clinical translation.

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The role of nanotherapy in head and neck squamous cell carcinoma by targeting tumor microenvironment

Cited by 6 publications

References 143 publications

Lipid-Coated Polymeric Nanoparticles for the Photodynamic Therapy of Head and Neck Squamous Cell Carcinomas

Lipid-Coated Polymeric Nanoparticles for the Photodynamic Therapy of Head and Neck Squamous Cell Carcinomas

Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma

Precision USPIO-PEG-SLex Nanotheranostic Agent Targeted Photothermal Therapy for Enhanced Anti-PD-L1 Immunotherapy to Treat Immunotherapy Resistance

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