The Role of Nasal Secretion and Serum Antibody in the Rhinovirus Common Cold1

Tr, Cate; Rd, Rossen; Rg, Douglas; Wt, Butler; Rb, Couch

doi:10.1093/oxfordjournals.aje.a120648

Cited by 124 publications

(51 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was originally intended that all three immunoglobulins would be absorbed, but this proved impracticable owing to insufficient volume of the secretions. The present study has shown IgA to be the predominant immunoglobulin in the secretions (Table 3), as in a number of other investigations which have indicated that antiviral activity in adult nasal secretions resides in the IgA fraction (Cate et al 1966;Alford et al 1967;Smith et al 1967). Therefore, the absorption studies were for IgA only, and it proved possible to remove the R.S.…”

Section: Resultssupporting

confidence: 88%

“…A number of investigations have shown that the predominant immunoglobulin in adult nasal secretions is IgA (Remington, Vosti, Lietze & Zimmerman, 1964;Rossen, Schade, Butler & Kasel, 1966). Moreover, antibody activity in adult nasal secretions, following various rhinovirus, influenza and parainfluenza infections, has been predominantly in the IgA fraction (Cate et al 1966;Alford et al 1967;Smith, Bellanti & Chanock, 1967;Perkins et al 1969). There have been few parallel studies for the immunoglobulins of nasal secretions of infants and young children (Haworth & Dilling, 1966;Cohen, Goldberg & London, 1970).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The local antibody response to R.S. virus infection in the respiratory tract

Scott

Gardner

1974

J. Hyg.

View full text Add to dashboard Cite

SUMMARYNasopharyngeal secretions were taken during the acute phase of illness from 66 infants and children admitted to hospital with lower respiratory tract infections. Second secretions were taken, after an interval of 7 days, from 33 of these patients. A significant increase in neutralizing activity to R.S. virus was demonstrated in the nasopharyngeal secretions of patients in response to severe R.S. virus infection.Seventeen out of 25 patients (68 %) with R.S. virus infections developed a rise in secretory neutralizing titre, compared with only 1 out of 8 patients (13 %) with respiratory infections not involving R.S. virus.A high titre of secretory neutralizing activity was found more often in the acute phase of illness in patients with R.S. virus infections, especially bronchiolitis, than in patients with respiratory infections not involving R.S. virus. A quantitative analysis of the immunoglobulins present in the secretions indicated that IgA was the only immunoglobulin consistently present at a detectable concentration. The geometric mean values of IgA, IgM and IgG in the secre tions examined were found to be 22-3 ,4 3 and 5-3 mg./100 ml. respectively.The neutralizing activity against R.S. virus, present in the secretions, was shown to be due to specific IgA antibody. This was accomplished by removing the neutralizing activity in two secretions by absorption with anti-IgA serum.

show abstract

Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

The local antibody response to R.S. virus infection in the respiratory tract

Scott

Gardner

1974

J. Hyg.

View full text Add to dashboard Cite

show abstract

“…Since neutralizing antibody is not detected until 14 days after infection (4), recovery from illness, which occurs within 7-10 days of infection, is probably mediated by other agents. On the other hand, resistance to illness and infection has been associated with high pre-existing neutralizing antibody titres (4)(5)(6)(7), a finding which we have recently confirmed (8).…”

Section: Introductionsupporting

confidence: 77%

The time course of the humoral immune response to rhinovirus infection

et al. 1989

View full text Add to dashboard Cite

SUMMARYThe specific humoral immune response of 17 volunteers to infection with human rhinovirus type 2 (HRV-2) has been measured both by neutralization and by ELISA. Six volunteers who had HRV-2-specific antibodies in either serum or nasal secretions before HRV-2 inoculation were resistant to infection and illness. Of the remaining 11 volunteers who had little pre-existing HRV-2-specific antibody, one was immune but 10 became infected and displayed increases in HRV-2-specific antibodies. These antibodies first increased 1-2 weeks after infection and reached a maximum at 5 weeks. All six resistant volunteers who had high pre-existing antibody and eight of the volunteers who became infected maintained their HRV-2-specific antibody for at least 1 year. At this time they were protected against reinfection. Two volunteers showed decreases in HRV-2-specific antibodies from either serum or nasal secretions. They became infected but not ill after HRV-2 inoculation 1 year later.

show abstract

“…Smith et al (1966) found that titres of nasal antibody to parainfluenza virus type 1 remained high for 5 weeks and that antibody was still detectable in some cases after 8 months. Cate et al (1966) found that rhinovirus antibodies were still present in nasal secretions after 56 days with little evidence of fall in titre. Although reinfection with both these agents can occur, resistance to reinfection is probably closely related to the nasal antibody titre.…”

Section: Discussionmentioning

confidence: 91%

Nasal immunoglobulin responses in acute rubella determined by the immunofluorescent technique

Cradock-Watson

Ridehalgh

Bourne

et al. 1973

J. Hyg.

View full text Add to dashboard Cite

SUMMARYThe indirect immunofluorescent technique has been used to study the specific immunoglobulin responses in nasal secretions from ten adults with acute rubella. Titres of IgA antibody in nasal washings usually exceeded those of IgG, but both types of antibody were detected in all patients. They appeared a few days after the rash, reached maximum titres during the second week and then declined. IgA antibody was no longer detectable after 47 days and was not detected at all in nasal washings from adults who had experienced rubella in the past. Low titres of IgG antibody persisted in some patients for longer than IgA and traces of IgG were found in nasal washings from a minority of adults with a past history of rubella. Nasal antibodies in acute rubella are therefore transient and unlikely to take part in resistance to reinfection.In sucrose-density gradients nasal IgA antibody sedimented more rapidly than IgG and there was little overlap between these two types of antibody. IgA antibody in serum was more heterogeneous; it was found in nearly all the fractions which contained IgG antibody and in many of those which contained IgM.

show abstract

The Role of Nasal Secretion and Serum Antibody in the Rhinovirus Common Cold1

Cited by 124 publications

References 0 publications

The local antibody response to R.S. virus infection in the respiratory tract

The local antibody response to R.S. virus infection in the respiratory tract

The time course of the humoral immune response to rhinovirus infection

Nasal immunoglobulin responses in acute rubella determined by the immunofluorescent technique

Contact Info

Product

Resources

About