The role of natural anti-parasitic guided development of synthetic drugs for leishmaniasis

Pal, Rohit; Teli, Ghanshyam; Matada, Gurubasavaraja Swamy Purawarga

doi:10.1016/j.ejmech.2023.115609

Cited by 11 publications

(2 citation statements)

References 77 publications

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“…These include, for example, marbofloxacin, a third-generation fluoroquinolone, and DDD853651/GSK3186899, a pyrazolopyrimidine ( Sheikh et al, 2024 ). Natural compounds such as chalcones, alkaloids, quinolines and pyridines have also been shown to be effective against these parasites ( Pal et al, 2023 ), with ursolic acid, coumarin, gallic acid and apigenin, among others, being particularly active ( Afonso et al, 2023 ). In addition, other strategies such as the combination of drugs with immunotherapy have shown encouraging results.…”

Section: Introductionmentioning

confidence: 99%

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Bethencourt-Estrella,

Delgado-Hernández,

López-Arencibia

et al. 2024

International Journal for Parasitology: Drugs and Drug Resistan

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Section: Introductionmentioning

confidence: 99%

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Bethencourt-Estrella,

Delgado-Hernández,

López-Arencibia

et al. 2024

International Journal for Parasitology: Drugs and Drug Resistan

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“…Processes 2023, 11, 3227 2 of 18 widespread disease that causes between 20,000 and 30,000 deaths each year, making it a major health problem in endemic areas. Due to the inefficacy of current medications, the improvement of leishmaniasis treatment via the administration of drugs poses a significant challenge [4,5].…”

Section: Introductionmentioning

confidence: 99%

Ericaria amentacea Algae Extracts: A Sustainable Approach for the Green Synthesis of Silver Oxide Nanoparticles and Their Effectiveness against Leishmaniasis

Mohamed Abdoul-Latif,

Ainane,

Aboubaker

et al. 2023

Processes

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In this study, anti-leishmanial activities were performed on silver oxide nanoparticles green synthesized from hexane, ethereal, chloroform, and methanolic extracts of the Ericaria amentacea seaweed. The extracts were obtained using a soxhlet extraction system, and the silver oxide nanoparticles were synthesized through a simple and environmentally friendly method. Physicochemical characterizations, including UV spectrophotometry, transmission electron microscopy (TEM), X-ray diffraction (XRD), thermal gravimetry analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), and zeta potential analysis (ZPA), were conducted to confirm the formation of silver oxide particles. The anti-leishmanial activity was evaluated in vitro using the MTT assay against the Leishmania infantum, Leishmania tropica, and Leishmania major strains. Additionally, a brine shrimp cytotoxicity test was performed on Artemia salina larvae to assess the toxicity of the products. The results showed that the anti-leishmanial activity of the synthesized silver oxide nanoparticles was significant, with inhibitory concentration values ranging from 27.16 μg/mL to 38.18 μg/mL. The lethal doses in the cytotoxicity activities were higher than 17.08 μg/mL, indicating low toxicity. These findings suggest that silver oxide nanoparticles derived from Ericaria amentacea seaweed have potential applications in the treatment of leishmaniasis. Further research is needed to elucidate the mechanisms of action and assess the in vivo efficacy of these nanoparticles. Moreover, comprehensive toxicity studies are necessary before considering their clinical use in leishmaniasis treatment.

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Exploring the Anticancer Potential of Triazine Derivatives: An Outlook of Designing Strategies, Docking Studies, and Structure‐Activity Relationships (SAR)

Manjushree,

Matada,

Pal

et al. 2024

ChemistrySelect

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Cancer is a disease characterized by uncontrolled cell growth resulting from genetic and epigenetic changes accumulating within a cancer cell population. Despite the milestone discovery of chemotherapeutic drugs against cancer, cancer remains tough to cure. Therefore, cancer has the second‐highest global death rate. There are certain factors such as genetic mutation, cancer cell diversity, metastasis, and resistance, which limit chemotherapy. To combat cancer, it's crucial to find novel therapeutic tactics and produce novel drugs that target cancer cells without affecting healthy cells. Heterocyclic compounds influence certain molecular targets to find novel lead structures can be a noteworthy strategy for the development of potential anticancer agents. Triazine, a low‐cost and widely available heterocyclic scaffold, has piqued researchers’ interest in developing innovative designing strategies. This review presents the advancement of three different isomers of triazines as anticancer agents. The main focus of this review is to provide the advancement of designing strategies, structure‐activity relationships, and docking studies of triazine derivatives as anticancer agents the available triazine‐containing drugs, and the status of clinical trials of triazine‐containing drugs were also highlighted. Lastly, we have also concluded the most potent derivatives and their hybridization with another ring to justify the particular anticancer activity.

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The role of natural anti-parasitic guided development of synthetic drugs for leishmaniasis

Cited by 11 publications

References 77 publications

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Ericaria amentacea Algae Extracts: A Sustainable Approach for the Green Synthesis of Silver Oxide Nanoparticles and Their Effectiveness against Leishmaniasis

Exploring the Anticancer Potential of Triazine Derivatives: An Outlook of Designing Strategies, Docking Studies, and Structure‐Activity Relationships (SAR)

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