The Role of Natural Antioxidants in Cancer Disease

Moreno, Esther

doi:10.5772/51503

Cited by 17 publications

(12 citation statements)

References 141 publications

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“…Phytoconstituents may protect the cells from oxidative stress by scavenging free radicals or by preventing their excessive generation in stressful conditions, for example by chelating prooxidative metal ions [ 6 , 7 ]. High consumption of foods rich in natural antioxidants was proved to significantly reduce the risk of several types of cancer, including colon, breast, prostate and bladder cancer [ 8 ]. Moreover, societies consuming large amount of fresh fruit and vegetables display significantly lower incidence of lifestyle disorders [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Stevia Rebaudiana Bert. Leaf Extracts as a Multifunctional Source of Natural Antioxidants

et al. 2015

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The aim of the presented study was to characterize the content and biological activity of extracts prepared from dried Stevia rebaudiana leaves with potential application in the food or cosmetic industry. Aqueous (A), ethanolic (E) and glycol-aqueous (GA) extracts were analyzed for the content of polyphenols and proteins, showing that the highest amount of phenols (15.50 mg/g) and flavonoids (3.85 mg/g) contained GA. All extracts contained significant amount of protein (69.40–374.67 mg/g). Between analyzed stevia extracts (HPLC) GA contained the highest amount of polyphenols, especially ferulic (5.50 mg/g) and rozmaric (4.95 mg/g) acids derivates. The highest antiradical activity against DPPH• and ABTS•+ was noted for GA and E (IC50 = 0.38 and 0.71 µg flavonoids/mL). The highest ability to chelate Fe2+ was observed for E (IC50 = 2.08 µg flavonoids/mL). Stevia extracts were also analyzed for their cytotoxicity and fibroblast irritation potential in vitro. E and GA were the most cytotoxic and irritating, probably due to the high content of biologically active phytochemicals. On the other hand, a extract was the most tolerable by the cells. To summarize, the presented study evaluated the potential application of A, E and GA stevia extracts as natural source of antioxidants in the food and cosmetic industry.

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Section: Introductionmentioning

confidence: 99%

Stevia Rebaudiana Bert. Leaf Extracts as a Multifunctional Source of Natural Antioxidants

et al. 2015

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“…Se deficiency alone rarely leads to clinical manifestation, but in association with other factors, exacerbates disease manifestation 6,7. Normal physiological reactions usually generate oxygen and nitrogen reactive species which are quickly neutralised by endogenous anti-oxidants such as the selenium dependent glutathione 8. The most basic oxidant molecules are superoxide and its metabolite hydrogen peroxide (H 2 O 2 ), which are produced from 1–4% of the inspired oxygen by the normal physiological activities of energy producing mitochondria, metabolic function of the endoplasmic reticulum, and defensive/ inflammatory role of lysosomes and other cellular organelles13.…”

Section: Discussionmentioning

confidence: 99%

“…The most basic oxidant molecules are superoxide and its metabolite hydrogen peroxide (H 2 O 2 ), which are produced from 1–4% of the inspired oxygen by the normal physiological activities of energy producing mitochondria, metabolic function of the endoplasmic reticulum, and defensive/ inflammatory role of lysosomes and other cellular organelles13. In selenium deficiency, there is diminished glutathione peroxidase anti-oxidant capacity, accumulation of superoxide and hydrogen peroxide and lipid peroxides with resultant oxidative damage to structural proteins and lipids, enzymatic and repair proteins, signalling molecules and DNA predisposing to progressive multi-organ damage, increased risk of chronic degenerative diseases and malignancy 8,9…”

Section: Discussionmentioning

confidence: 99%

Diagnostic performance of several biomarkers for identification of cases of non-communicable diseases among Central Africans

et al. 2018

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BackgroundThis study determined the diagnostic performance of new biomarkers for a composite diagnosis of non-communicable diseases (NCDs) among Central Africans.MethodsThis case-control study was conducted at LOMO Medical Centre, Kinshasa, DR Congo (DRC) between January – December, 2008. The cases comprised 226 participants with concurrent presence of at least 2 or more of NCDs. Anthropometric parameters and blood pressure were measured while blood samples were assayed for biomarkers. The receiver operating characteristics curve and the logistic regression model were applied.ResultsSerum selenium (Se) had specificity and sensitivity of 72.4% and 91.1%, respectively with an area under the curve (AUC) of 0.802; Nitric oxide (NO) (specificity: 72.4%; sensitivity: 93.0%) (AUC = 0.800); Thyroid stimulating hormone (TSH) levels > 6 Mu/L (specificity: 75%; sensitivity: 65%) (AUC = 0.0.727); serum calcium levels of ≥ 110g/L (specificity: 76%; sensitivity: 75%) (AUC = 0.822); and daily salt intake of ≥10 g/day (specificity: 75%; sensitivity: 67%) (AUC = 0.653) in the diagnosis of all NCDs, which were all highly significant (<0.0001).ConclusionSerum Se, NO, calcium, TSH and daily salt intake had high diagnostic performance as biomarkers for identification of patients with concurrent NCDs in the study population.

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“…Increased plasma and tissue concentrations of these oxidative stress second messengers have been reported in lung, gastric, colon, and breast cancers [ 7 – 10 ]. These findings call attention to the role of antioxidant deficiency or increased free radicals in producing such effects and provide a starting point for research into the therapeutic potential of antioxidants in cancer, which was later confirmed to be related to cellular and genetic damage induced by reactive forms of oxygen [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants

Zahra

Lefter

Ali

et al. 2021

Oxidative Medicine and Cellular Longevity

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Oxygen-free radicals, reactive oxygen species (ROS) or reactive nitrogen species (RNS), are known by their “double-sided” nature in biological systems. The beneficial effects of ROS involve physiological roles as weapons in the arsenal of the immune system (destroying bacteria within phagocytic cells) and role in programmed cell death (apoptosis). On the other hand, the redox imbalance in favor of the prooxidants results in an overproduction of the ROS/RNS leading to oxidative stress. This imbalance can, therefore, be related to oncogenic stimulation. High levels of ROS disrupt cellular processes by nonspecifically attacking proteins, lipids, and DNA. It appears that DNA damage is the key player in cancer initiation and the formation of 8-OH-G, a potential biomarker for carcinogenesis. The harmful effect of ROS is neutralized by an antioxidant protection treatment as they convert ROS into less reactive species. However, contradictory epidemiological results show that supplementation above physiological doses recommended for antioxidants and taken over a long period can lead to harmful effects and even increase the risk of cancer. Thus, we are describing here some of the latest updates on the involvement of oxidative stress in cancer pathology and a double view on the role of the antioxidants in this context and how this could be relevant in the management and pathology of cancer.

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The Role of Natural Antioxidants in Cancer Disease

Cited by 17 publications

References 141 publications

Stevia Rebaudiana Bert. Leaf Extracts as a Multifunctional Source of Natural Antioxidants

Stevia Rebaudiana Bert. Leaf Extracts as a Multifunctional Source of Natural Antioxidants

Diagnostic performance of several biomarkers for identification of cases of non-communicable diseases among Central Africans

The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants

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