The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation

Khadka, Bikram; Lee, Jae-Young; Park, Dong Ho; Kim, Ki-Taek; Bae, Jong‐Sup

doi:10.3390/biom10101401

Cited by 15 publications

(7 citation statements)

References 246 publications

(285 reference statements)

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“…Prolonged microglial activation, and in particular of the M1 pro-inflammatory microglia, can contribute to neuroinflammatory responses ( 56 ) also through endothelial and BBB dysfunction ( 57 ). Moreover, the oxidative stress caused by reactive oxygen/nitrogen species and mitochondrial disarrangements play key roles in neuroinflammation ( 58 , 59 ). Pro-inflammatory cytokines and high nitric oxide (NO) levels produced by activated microglia may promote reactive oxygen species (ROS) formation ( 60 ).…”

Section: Depression Bipolar Disorders Obsessive-compulsive Disordermentioning

confidence: 99%

The Impact of Nutrients on Mental Health and Well-Being: Insights From the Literature

Muscaritoli

2021

Front. Nutr.

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A good nutritional status is important for maintaining normal body function and preventing or mitigating the dysfunction induced by internal or external factors. Nutritional deficiencies often result in impaired function, and, conversely, intakes at recommended levels can resume or further enhance body functions. An increasing number of studies are revealing that diet and nutrition are critical not only for physiology and body composition, but also have significant effects on mood and mental well-being. In particular, Western dietary habits have been the object of several research studies focusing on the relationship between nutrition and mental health. This review aims to summarize the current knowledge about the relationship between the intake of specific micro- and macronutrients, including eicosapentaenoic acid, docosahexaenoic acid, alpha-tocopherol, magnesium and folic acid, and mental health, with particular reference to their beneficial effect on stress, sleep disorders, anxiety, mild cognitive impairment, as well as on neuropsychiatric disorders, all significantly affecting the quality of life of an increasing number of people. Overall data support a positive role for the nutrients mentioned above in the preservation of normal brain function and mental well-being, also through the control of neuroinflammation, and encourage their integration in a well-balanced and varied diet, accompanied by a healthy lifestyle. This strategy is of particular importance when considering the global human aging and that the brain suffers significantly from the life-long impact of stress factors.

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Section: Depression Bipolar Disorders Obsessive-compulsive Disordermentioning

confidence: 99%

The Impact of Nutrients on Mental Health and Well-Being: Insights From the Literature

Muscaritoli

2021

Front. Nutr.

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“…The prominent role inflammation plays in various age-related diseases such as AD, PD, and central nervous system (CNS) injury ( Khadka et al, 2020 ). Glial cells and immune cells are associated with the instigation of neuroinflammation.…”

Section: Neuroprotection Potential Of Acmentioning

confidence: 99%

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

Li,

Wan,

Qiao

et al. 2024

Front. Pharmacol.

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Prevalent neurological disorders such as Alzheimer’s disease, Parkinson’s disease, and stroke are increasingly becoming a global burden as society ages. It is well-known that degeneration and loss of neurons are the fundamental underlying processes, but there are still no effective therapies for these neurological diseases. In recent years, plenty of studies have focused on the pharmacology and feasibility of natural products as new strategies for the development of drugs that target neurological disorders. Antrodia camphorata has become one of the most promising candidates, and the crude extracts and some active metabolites of it have been reported to play various pharmacological activities to alleviate neurological symptoms at cellular and molecular levels. This review highlights the current evidence of Antrodia camphorata against neurological disorders, including safety evaluation, metabolism, blood-brain barrier penetration, neuroprotective activities, and the potential on regulating the gut-microbiome-brain axis. Furthermore, potential strategies to resolve problematic issues identified in previous studies are also discussed. We aim to provide an overview for the ongoing development and utilization of Antrodia camphorata in cerebral neuropathology.

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“…The delicate balance between nerve connections, spinal cord, and the control center, the brain, is easily perturbed by exogenous insults and endogenous degenerative conditions. Debilitating disorders of the central nervous system (CNS) include Alzheimer's disease (AD) [17] and variants of dementia such as Lewy body dementia (LBD), tumors such as neuroblastoma and glioblastoma [18], as well as dyskinesia-related conditions such as Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) [19]. Alzheimer's disease is a type of neurodegenerative disease that is described by the formation of plaques with tangled neurofibers composed of amyloid and tau proteins.…”

Section: Nano-phytopharmaceuticals In Neurological (Cns) Disordersmentioning

confidence: 99%

Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications

et al. 2022

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Phytopharmaceuticals have been widely used globally since ancient times and acknowledged by healthcare professionals and patients for their superior therapeutic value and fewer side-effects compared to modern medicines. However, phytopharmaceuticals need a scientific and methodical approach to deliver their components and thereby improve patient compliance and treatment adherence. Dose reduction, improved bioavailability, receptor selective binding, and targeted delivery of phytopharmaceuticals can be likely achieved by molding them into specific nano-formulations. In recent decades, nanotechnology-based phytopharmaceuticals have emerged as potential therapeutic candidates for the treatment of various communicable and non-communicable diseases. Nanotechnology combined with phytopharmaceuticals broadens the therapeutic perspective and overcomes problems associated with plant medicine. The current review highlights the therapeutic application of various nano-phytopharmaceuticals in neurological, cardiovascular, pulmonary, and gastro-intestinal disorders. We conclude that nano-phytopharmaceuticals emerge as promising therapeutics for many pathological conditions with good compliance and higher acceptance.

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The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation

Cited by 15 publications

References 246 publications

The Impact of Nutrients on Mental Health and Well-Being: Insights From the Literature

The Impact of Nutrients on Mental Health and Well-Being: Insights From the Literature

Current and further outlook on the protective potential of Antrodia camphorata against neurological disorders

Precision and Advanced Nano-Phytopharmaceuticals for Therapeutic Applications

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