The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: Major contributors or essential homeostatic modulators?

Ahern, David J; Brennan, Fionula M.

doi:10.1016/j.imlet.2010.11.001

Cited by 51 publications

(54 citation statements)

References 91 publications

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“…This finding confirms earlier results that found preferential expression in T cells for genes near RA-associated SNPs (13). In addition, our analysis indicates a strong enrichment of RA-associated SNPs in NK-cell enhancers, suggesting that the possible role of NK cells in RA pathogenesis may deserve more attention (14).…”

Section: Discussionsupporting

confidence: 92%

Enrichment of Genetic Variants for Rheumatoid Arthritis within T-Cell and NK-Cell Enhancer Regions

Freudenberg

Gregersen

2015

Mol Med

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Section: Discussionsupporting

confidence: 92%

Enrichment of Genetic Variants for Rheumatoid Arthritis within T-Cell and NK-Cell Enhancer Regions

Freudenberg

Gregersen

2015

Mol Med

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“…The contribution of NK cells to arthritis has been unclear, in part because of the diverse activities of this lymphocyte subset (18). Our experimental approach has revealed the importance of NK cells in regulating arthritis in an animal model.…”

Section: Discussionmentioning

confidence: 98%

Mobilization of natural killer cells inhibits development of collagen-induced arthritis

Leavenworth

Wang

Wenander

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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Although natural killer (NK) cells have been implicated in regulating immune responses, their ability to modulate disease development in autoimmune arthritis has not been analyzed. Here we investigate the contribution of NK cells to regulating collagen-induced arthritis, a well-characterized preclinical model of human rheumatoid arthritis. We find that the disease is induced by the combined action of two CD4 + T helper (T H ) subsets: follicular T H cells and T H 17 cells. Both CD4 + T H subsets are highly susceptible to lysis by NK cells after activation. Administration of antibody that activates NK cells through blockade of its inhibitory CD94/NKG2A receptor allows enhanced elimination of pathogenic follicular T H and T H 17 cells and arrest of disease progression. These results suggest that antibody-dependent enhancement of NK activity may yield effective, previously undescribed therapeutic approaches to this autoimmune disorder.

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“…NK cells are considered pathogenic elements in the development of the disease (34,35). The proportions of CD56 bright and CD56 dim NK cells in the peripheral blood of RA patients are similar to those in healthy subjects (36)(37)(38)(39).…”

Section: Cd56mentioning

confidence: 97%

Human CD56bright NK Cells: An Update

Michel

Poli

Cuapio

et al. 2016

The Journal of Immunology

326

273

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Human NK cells can be subdivided into various subsets based on the relative expression of CD16 and CD56. In particular, CD56brightCD16−/dim NK cells are the focus of interest. They are considered efficient cytokine producers endowed with immunoregulatory properties, but they can also become cytotoxic upon appropriate activation. These cells were shown to play a role in different disease states, such as cancer, autoimmunity, neuroinflammation, and infection. Although their phenotype and functional properties are well known and have been extensively studied, their lineage relationship with other NK cell subsets is not fully defined, nor is their precise hematopoietic origin. In this article, we summarize recent studies about CD56bright NK cells in health and disease and briefly discuss the current controversies surrounding them.

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The role of Natural Killer cells in the pathogenesis of rheumatoid arthritis: Major contributors or essential homeostatic modulators?

Cited by 51 publications

References 91 publications

Enrichment of Genetic Variants for Rheumatoid Arthritis within T-Cell and NK-Cell Enhancer Regions

Enrichment of Genetic Variants for Rheumatoid Arthritis within T-Cell and NK-Cell Enhancer Regions

Mobilization of natural killer cells inhibits development of collagen-induced arthritis

Human CD56bright NK Cells: An Update

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