The role of NCAPG in various of tumors

Cai, Xin; Gao, Jie; Shi, Chengcheng; Guo, Wen Zhi; Guo, Dongyun; Zhang, Shuijun

doi:10.1016/j.biopha.2022.113635

Cited by 14 publications

(5 citation statements)

References 62 publications

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“…Despite this, ER and PR may still demonstrate extremely low expression levels. In relevance to breast cancer, NCAPG gene expression is regulated by four miRNAs (miR-195-5p, miR-101-3p, miR-944, and miR-214-3p) and 12 coexpressed genes by interacting with the p53 signaling pathway. , Additionally, it was noted that high NCAPG expression is linked to a bad prognosis for various tumor types, and its overexpression may be crucial for controlling tumor-related pathways during tumor growth …”

Section: Discussionmentioning

confidence: 99%

Deciphering the miRNA–mRNA Interaction Landscape between Breast Cancer and Triple-Negative Breast Cancer: An Integrated Bioinformatics Approach

Balasundaram,

Mitra,

Tayubi

et al. 2024

ACS Omega

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Breast cancer (BC) is globally recognized as the second most prevalent form of cancer. It predominantly affects women and can be categorized into distinct types based on the overexpression of specific cancer receptors.The key receptors implicated in this context are the human epidermal growth factor receptor-2 (HER2), estrogen receptor (ER), and progesterone receptor (PR), alongside a particularly intricate subclass known as triple-negative breast cancer (TNBC). This subclassification is critical for the stratification of breast cancer and informs therapeutic decision-making processes. Due to a lack of therapeutic targets, such as growth factor receptors, TNBC is the most aggressive type. Hence, identifying targetable regulators such as miRNAs could pave the way for potential therapeutic interventions. To identify common differentially expressed mRNAs (DE-mRNAs) in BC, including TNBC, we leveraged two data sets from the GEO collection and The Cancer Genome Atlas (TCGA). Significant DE-mRNAs were identified through PPI, MCODE, CytoNCA, and CytoHubba analyses. Following this, miRNAs were predicted using mirDIP. We utilized GSE42568, GSE185645, and TCGA and identified 159 common DE-mRNAs. Using Cytoscape plug-ins, we identified the 10 most significant DE-mRNAs in BC. Using mirDIP, target miRNAs for 10 DE-mRNAs were identified. We conducted an advanced analysis on the TNBC GEO data set (GSE45498) to corroborate the significance of shared DE-mRNAs and DE-miRNAs in TNBC. We identified four downregulated DE-miRNAs, including hsa-miR-802, hsa-miR-1258, hsa-miR-548a-3p, and hsa-miR-2053, significantly associated with TNBC. Our study revealed significant miRNA−mRNA interactions, specifically hsa-miR-802/ MELK, hsa-miR-1258/NCAPG, miR-548a-3p/CCNA2, and hsa-miR-2053/NUSAP1, in both BC and TNBC. The observed downregulation of hsa-miR-548a-3p is associated with diminished survival rates in BC patients, emphasizing their potential utility as prognostic indicators. Furthermore, the differential expression of mRNAs, including CCNB2, UBE2C, MELK, and KIF2C, correlates with reduced survival outcomes, signifying their critical role as potential targets for therapeutic intervention in both BC and TNBC. These findings highlight specific regulatory mechanisms that are potentially crucial for understanding and treating these cancer types.

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Section: Discussionmentioning

confidence: 99%

Deciphering the miRNA–mRNA Interaction Landscape between Breast Cancer and Triple-Negative Breast Cancer: An Integrated Bioinformatics Approach

Balasundaram,

Mitra,

Tayubi

et al. 2024

ACS Omega

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“…NCAPG is a chromosome condensation protein associated with mitosis and meiosis, responsible for the condensation and stability of chromosomes during these processes. Studies have shown that NCAPG has a highly regulatory role in multiple cancers, and its related molecular mechanisms affect tumor cell proliferation, invasion, metastasis, and apoptosis, including liver cancer, prostate cancer, breast cancer, gastric cancer, glioma, LUAD, colorectal cancer, ovarian cancer, and endometrial cancer, among others [ 28 ]. NDC80 is a subunit of the NDC80 complex and forms and stabilizes the attachment of microtubules to kinetochores during chromosome segregation in mitosis [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Hub Genes for Psoriasis and Cancer by Bioinformatic Analysis

Yu,

Ma,

Zhou

2024

BioMed Research International

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Psoriasis increases the risk of developing various cancers, including colon cancer. The pathogenesis of the co‐occurrence of psoriasis and cancer is not yet clear. This study is aimed at analyzing the pathogenesis of psoriasis combined with cancer by bioinformatic analysis. Skin tissue data from psoriasis (GSE117239) and intestinal tissue data from colon cancer (GSE44076) were downloaded from the GEO database. One thousand two hundred ninety‐six common differentially expressed genes and 688 common shared genes for psoriasis and colon cancer were determined, respectively, using the limma R package and weighted gene coexpression network analysis (WGCNA) methods. The results of the GO and KEGG enrichment analyses were mainly related to the biological processes of the cell cycle. Thirteen hub genes were selected, including AURKA, DLGAP5, NCAPG, CCNB1, NDC80, BUB1B, TTK, CCNB2, AURKB, TOP2A, ASPM, BUB1, and KIF20A. These hub genes have high diagnostic value, and most of them are positively correlated with activated CD4 T cells. Three hub transcription factors (TFs) were also predicted: E2F1, E2F3, and BRCA1. These hub genes and hub TFs are highly expressed in various cancers. Furthermore, 251 drugs were predicted, and some of them overlap with existing therapeutic drugs for psoriasis or colon cancer. This study revealed some genetic mechanisms of psoriasis and cancer by bioinformatic analysis. These hub genes, hub TFs, and predicted drugs may provide new perspectives for further research on the mechanism and treatment.

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“…NCAPG (non-SMC condensin I complex, subunit G) is a mitose-associated chromosome condensation protein (32). Related studies have shown that NCAPG is signi cantly overexpressed in various tumors, including colorectal cancer, hepatocellular carcinoma, lung cancer, etc., and affects the biological functions of tumor cells such as proliferation, migration, invasion and apoptosis (33)(34)(35). For instance, NCAPG can promote the growth and metastasis of non-small cell lung cancer by upregulating LGALS1, and can promote the proliferation, invasion and epithelial-mesenchymal transition of colorectal cancer cells by activating Wnt/β-catenin pathway (36, 37).…”

Section: Discussionmentioning

confidence: 99%

Lawsone inhibits the proliferation and metastasis of residual breast cancer cells after microwave ablation by inducing cellular inhibitory autophagy through NCAPG/AURKB/AKT/mTOR axis

Sun

Tong

Zhang

et al. 2023

Preprint

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Microwave ablation (MWA) is increasingly used in clinical treatment and research of breast cancer, which has good therapeutic effect on primary and metastatic lesions. However, microwave ablation may lead to residual tumor cells due to incomplete ablation. The biological characteristics of residual tumor cells are unknown, and it is necessary to explore new adjuvant treatment methods to achieve better therapeutic effect. In this study, we demonstrated that the migration ability of residual breast cancer cells was enhanced after microwave ablation, but the proliferation ability was not significantly changed. Lawsone, an active ingredient in Chinese herbal medicine, significantly inhibited the proliferation and metastasis of residual breast cancer cells after microwave ablation in vivo and in vitro, and had synergistic effects with microwave ablation therapy. Mechanistic studies have shown that Lawsone exerts its anti-proliferation and anti-migration ability mainly by targeting NCAPG in residual breast cancer after microwave ablation. In addition, Lawsone-induced cellular inhibitory autophagy also plays a key role in its anticancer effect. In addition, NCAPG interacts with AURKB protein and jointly participates in the regulation of AKT/mTOR pathway to affect autophagy process. In short, these consequences demonstrate that Lawsone exerts its anti-proliferation and anti-metastasis effects on residual breast cancer cells after microwave ablation mainly by inhibiting NCAPG/AURKB/AKT/mTOR axis and inducing inhibitory autophagy, which provides more options for adjuvant therapy after microwave ablation.

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The role of NCAPG in various of tumors

Cited by 14 publications

References 62 publications

Deciphering the miRNA–mRNA Interaction Landscape between Breast Cancer and Triple-Negative Breast Cancer: An Integrated Bioinformatics Approach

Deciphering the miRNA–mRNA Interaction Landscape between Breast Cancer and Triple-Negative Breast Cancer: An Integrated Bioinformatics Approach

Identification of Hub Genes for Psoriasis and Cancer by Bioinformatic Analysis

Lawsone inhibits the proliferation and metastasis of residual breast cancer cells after microwave ablation by inducing cellular inhibitory autophagy through NCAPG/AURKB/AKT/mTOR axis

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