The role of necroptosis in common respiratory diseases in children

Ning, Junjie; Qiao, Liang

doi:10.3389/fped.2022.945175

Cited by 4 publications

(1 citation statement)

References 60 publications

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“…Cellular elements such as DAMP, HMGB1, mitochondrial DNA, uric acid, histones, and ATP are also simultaneously released into the extracellular space via the plasma membrane pores, inducing an inflammatory response. 243 , 246 , 247 …”

Section: Necroptosismentioning

confidence: 99%

Programmed Cell Death in Asthma: Apoptosis, Autophagy, Pyroptosis, Ferroptosis, and Necroptosis

Lü¹,

Zhou²,

Wang³

et al. 2023

JIR

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Bronchial asthma is a complex heterogeneous airway disease, which has emerged as a global health issue. A comprehensive understanding of the different molecular mechanisms of bronchial asthma may be an efficient means to improve its clinical efficacy in the future. Increasing research evidence indicates that some types of programmed cell death (PCD), including apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis, contributed to asthma pathogenesis, and may become new targets for future asthma treatment. This review briefly discusses the molecular mechanism and signaling pathway of these forms of PCD focuses on summarizing their roles in the pathogenesis and treatment strategies of asthma and offers some efficient means to improve clinical efficacy of therapeutics for asthma in the near future.

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Section: Necroptosismentioning

confidence: 99%

Programmed Cell Death in Asthma: Apoptosis, Autophagy, Pyroptosis, Ferroptosis, and Necroptosis

Lü¹,

Zhou²,

Wang³

et al. 2023

JIR

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Receptor-interacting protein kinase-3 (RIPK3): a new biomarker for necrotising enterocolitis in preterm infants

Shen,

Yang,

Gao

et al. 2024

Pediatr Surg Int

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Objective This study aimed to evaluate the role of receptor-interacting protein kinase-3 (RIPK3) in the diagnosis, estimation of disease severity, and prognosis of premature infants with necrotising enterocolitis (NEC). Methods RIPK3, lactic acid (LA), and C-reactive protein (CRP) levels were measured in the peripheral blood of 108 premature infants between 2019 and 2023, including 24 with stage II NEC, 18 with stage III NEC and 66 controls. Diagnostic values of the indicators for NEC were evaluated via receiver operating characteristic (ROC) curve analysis. Results Plasma RIPK3 and LA levels upon NEC suspicion in neonates with stage III NEC were 32.37 ± 16.20 ng/mL. The ROC curve for the combination of RIPK3, LA, CRP for NEC diagnosis were 0.925. The time to full enteral feeding (FEFt) after recovery from NEC was different between two expression groups of plasma RIPK3 (RIPK3 < 20.06 ng/mL and RIPK3 ≥ 20.06 ng/mL). Conclusion Plasma RIPK3 can be used as a promising marker for the diagnosis and estimation of disease severity of premature infants with NEC and for the guidance on proper feeding strategies after recovery from NEC.

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Screening, identification and targeted intervention of necroptotic biomarkers of asthma

Feng,

Wu,

Jia

et al. 2024

Biochemical and Biophysical Research Communications

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The role of necroptosis in common respiratory diseases in children

Cited by 4 publications

References 60 publications

Programmed Cell Death in Asthma: Apoptosis, Autophagy, Pyroptosis, Ferroptosis, and Necroptosis

Programmed Cell Death in Asthma: Apoptosis, Autophagy, Pyroptosis, Ferroptosis, and Necroptosis

Receptor-interacting protein kinase-3 (RIPK3): a new biomarker for necrotising enterocolitis in preterm infants

Screening, identification and targeted intervention of necroptotic biomarkers of asthma

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