The Role of Neighborhood Air Pollution Exposure on Somatic Non-Small Cell Lung Cancer Mutations in the Los Angeles Basin (2013–2018)

Letellier, Noémie; Wing, Sam E.; Yang, Jiue-An; Gray, Stacy W.; Benmarhnia, Tarik; Erhunmwunsee, Loretta; Jankowska, Marta M.

doi:10.3390/ijerph191711027

Cited by 5 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particulate matter with a diameter of less than 2.5 µm (PM), which contains benzopyrenes and polycyclic aromatic hydrocarbons, is a pollutant that induces DNA damage, inflammation, and angiogenesis, creating an environment that promotes tumor development [5,8]. For instance, there is evidence that PM exposure is associated with mutations in the TP53 gene [9].…”

Section: Epidemiology and Molecular/genetic Basis Of Lung Cancermentioning

confidence: 99%

Prognostic Factors and Markers in Non-Small Cell Lung Cancer: Recent Progress and Future Challenges

Meira,

de Castro e Caetano,

Casotti

et al. 2023

Genes

View full text Add to dashboard Cite

Lung cancer is a highly aggressive neoplasm and, despite the development of recent therapies, tumor progression and recurrence following the initial response remains unsolved. Several questions remain unanswered about non-small cell lung cancer (NSCLC): (1) Which patients will actually benefit from therapy? (2) What are the predictive factors of response to MAbs and TKIs? (3) What are the best combination strategies with conventional treatments or new antineoplastic drugs? To answer these questions, an integrative literature review was carried out, searching articles in PUBMED, NCBI-PMC, Google Academic, and others. Here, we will examine the molecular genetics of lung cancer, emphasizing NSCLC, and delineate the primary categories of inhibitors based on their molecular targets, alongside the main treatment alternatives depending on the type of acquired resistance. We highlighted new therapies based on epigenetic information and a single-cell approach as a potential source of new biomarkers. The current and future of NSCLC management hinges upon genotyping correct prognostic markers, as well as on the evolution of precision medicine, which guarantees a tailored drug combination with precise targeting.

show abstract

Section: Epidemiology and Molecular/genetic Basis Of Lung Cancermentioning

confidence: 99%

Prognostic Factors and Markers in Non-Small Cell Lung Cancer: Recent Progress and Future Challenges

Meira,

de Castro e Caetano,

Casotti

et al. 2023

Genes

View full text Add to dashboard Cite

show abstract

Impact of Exposure to Environmental Particulate Matter on the Onset of Giant Cell Arteritis

Bond,

Tomelleri,

Reatini

et al. 2024

Arthritis Care & Research

View full text Add to dashboard Cite

ObjectiveAim of the study is to investigate the association between exposure to particulate matter with aerodynamic diameter ≤10μm (PM10) and the development of giant cell arteritis (GCA) and its ischaemic complications.MethodsThis is case‐crossover study on consecutive patients who received a diagnosis of GCA in three hospitals in Northern Italy between 2013 and 2021. The PM10 hourly and daily average concentrations, collected in the Italian monitoring network and archived by ISPRA were determined using European reference. We used a Bayesian hierarchical model to determine patients’ daily exposure to them. We employed conditional logistic regression to estimate the effect of exposure on GCA symptoms onset or ischaemic complications.ResultsWe included 232 patients. A positive association was observed between exposure to PM10 and GCA risk, with an incremental odd of 27.1% (95% CI 5.8‐52.6) for every 10 μg/m3 increase in PM10 concentration within a 60‐day period. We did not find any significant association for shorter periods, nor with ischaemic complications. Subgroup analysis found a significantly higher incremental risk at a 60‐day lag for patients ≥70 years old. Comparing patients who were chronically exposed to high PM10 levels (26.9±13.8 μg/m3) to those who were not (11.9±7.9 μg/m3) revealed that only in the former group there was an association between GCA onset and increased PM10 levels in the preceding 60 days.ConclusionExposure to environmental PM10 in the preceding 60 days seems to be associated with an increased risk of developing GCA, especially in elderly subjects with prolonged exposure to high levels of air pollution.

show abstract

Multilevel Determinants of Cancer Health Disparities

Halbert

2023

Cancer Health Disparities

View full text Add to dashboard Cite

The Role of Neighborhood Air Pollution Exposure on Somatic Non-Small Cell Lung Cancer Mutations in the Los Angeles Basin (2013–2018)

Cited by 5 publications

References 37 publications

Prognostic Factors and Markers in Non-Small Cell Lung Cancer: Recent Progress and Future Challenges

Prognostic Factors and Markers in Non-Small Cell Lung Cancer: Recent Progress and Future Challenges

Impact of Exposure to Environmental Particulate Matter on the Onset of Giant Cell Arteritis

Multilevel Determinants of Cancer Health Disparities

Contact Info

Product

Resources

About