The role of neuroinflammation on pathogenesis of affective disorders

Rhie, Sung Ja; Jung, Euiseok; Shim, Insop

doi:10.12965/jer.2040016.008

Cited by 73 publications

(39 citation statements)

References 72 publications

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“…16 Neuroinflammation has also been found to play a role in the pathogenesis of psychiatric diseases including affective disorders, schizophrenia spectrum disorders, and substance abuse, especially alcohol abuse. 17 Proinflammatory cytokine dysregulation can induce changes in neurotransmitter metabolism, cause hypothalamicpituitary-adrenal axis dysregulation, or alter neuroplasticity.…”

Section: Discussionmentioning

confidence: 99%

Command Suicidal Hallucination as Initial Presentation of Coronavirus Disease 2019 (COVID-19): A Case Report

et al. 2020

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Section: Discussionmentioning

confidence: 99%

Command Suicidal Hallucination as Initial Presentation of Coronavirus Disease 2019 (COVID-19): A Case Report

et al. 2020

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“…Los procesos neuroinflamatorios son capaces de producir cambios en el metabolismo de neurotransmisores, provocar desregulación del eje hipotálamo-hipofisario-adrenal, activar la microglía, afectar a la neuroplasticidad y provocar cambios estructurales y funcionales en el cerebro, afectando a cognición y conducta. Se ha postulado que las citoquinas proinflamatorias son la base de la disrupción de todos estos sistemas, estando en la base patogénica de trastornos afectivos, pero también de procesos como la esquizofrenia, el trastorno bipolar y el consumo de drogas, en especial de alcohol [25].…”

Section: Tormenta De Citoquinas Y Sistema Nerviosounclassified

Influencia de la infección SARS-CoV-2 sobre enfermedades neurodegenerativas y neuropsiquiátricas: ¿una pandemia demorada?

et al. 2020

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INTRODUCCIÓN: La infección por el coronavirus SARS-CoV2 originada en Diciembre de 2019 en la región china de Wuhan ha adquirido proporciones pandémicas. A día de hoy ha ocasionado de Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic?ABSTRACT Introduction: SARS-CoV-2 was first detected in December 2019 in the Chinese city of Wuhan and has since spread across the world. At present, the virus has infected over 1.7 million people and caused over 100 000 deaths worldwide. Research is currently focused on understanding the acute infection and developing effective treatment strategies. In view of the magnitude of the epidemic, we conducted a speculative review of possible medium-and long-term neurological consequences of SARS-CoV-2 infection, with particular emphasis on neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin, based on the available evidence on neurological symptoms of acute SARS-CoV-2 infection. Development:We systematically reviewed the available evidence about the pathogenic mechanisms of SARS-CoV-2 infection, the immediate and lasting effects of the cytokine storm on the central nervous system, and the consequences of neuroinflammation for the central nervous system.Conclusions: SARS-CoV-2 is a neuroinvasive virus capable of triggering a cytokine storm, with persistent effects in specific populations. Although our hypothesis is highly speculative, the impact of SARS-CoV-2 infection on the onset and progression of neurodegenerative and neuropsychiatric diseases of neuroinflammatory origin should be regarded as the potential cause of a delayed pandemic that may have a major public health impact in the medium to long term. Cognitive and neuropsychological function should be closely monitored in COVID-19 survivors.

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“…Diseases with an autoimmune component such as optic neuromyelitis and multiple sclerosis [2], aging and obesity [3] can also be considered triggers of inflammation. Accumulating evidence suggests that neuroinflammation plays an important role in the etiology of mental disorders, a variety of neurological and somatic diseases, including epilepsy, Alzheimer's disease, Parkinson's disease, autism spectrum disorders, bipolar disorder, affective disorders, depression [4][5][6][7][8] and systemic lupus erythematosus [9,10]. Recent data suggests that neuroinflammation is one of the key processes in glaucoma and retinopathy [11][12][13][14], it is also important in the pathogenesis of heart failure [15].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Drug Resistance in the Pathogenesis of Epilepsy: Role of Neuroinflammation. A Literature Review

2021

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Epilepsy is a chronic neurological disorder characterized by recurring spontaneous seizures. Drug resistance appears in 30% of patients and it can lead to premature death, brain damage or a reduced quality of life. The purpose of the study was to analyze the drug resistance mechanisms, especially neuroinflammation, in the epileptogenesis. The information bases of biomedical literature Scopus, PubMed, Google Scholar and SciVerse were used. To obtain full-text documents, electronic resources of PubMed Central and Research Gate were used. The article examines the recent research of the mechanisms of drug resistance in epilepsy and discusses the hypotheses of drug resistance development (genetic, epigenetic, target hypothesis, etc.). Drug-resistant epilepsy is associated with neuroinflammatory, autoimmune and neurodegenerative processes. Neuroinflammation causes immune, pathophysiological, biochemical and psychological consequences. Focal or systemic unregulated inflammatory processes lead to the formation of aberrant neural connections and hyperexcitable neural networks. Inflammatory mediators affect the endothelium of cerebral vessels, destroy contacts between endothelial cells and induce abnormal angiogenesis (the formation of “leaky” vessels), thereby affecting the blood–brain barrier permeability. Thus, the analysis of pro-inflammatory and other components of epileptogenesis can contribute to the further development of the therapeutic treatment of drug-resistant epilepsy.

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The role of neuroinflammation on pathogenesis of affective disorders

Cited by 73 publications

References 72 publications

Command Suicidal Hallucination as Initial Presentation of Coronavirus Disease 2019 (COVID-19): A Case Report

Command Suicidal Hallucination as Initial Presentation of Coronavirus Disease 2019 (COVID-19): A Case Report

Influencia de la infección SARS-CoV-2 sobre enfermedades neurodegenerativas y neuropsiquiátricas: ¿una pandemia demorada?

Mechanisms of Drug Resistance in the Pathogenesis of Epilepsy: Role of Neuroinflammation. A Literature Review

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