The role of neuroplastin65 in macrophage against E. coli infection in mice

Ren, H.; Xia, Xiaoxue; Dai, Xueting; Dai, Yue

doi:10.1016/j.molimm.2022.08.003

Cited by 4 publications

(3 citation statements)

References 52 publications

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“…Macrophages play a key role in providing protection against a range of infections. [ 34–36 ] Ren et al. showed that macrophages could clear E. coli infection in a mouse model when exposed to intraperitoneal infection.…”

Section: Resultsmentioning

confidence: 99%

“…Macrophages play a key role in providing protection against a range of infections. [34][35][36] Ren et al showed that macrophages could clear E. coli infection in a mouse model when exposed to intraperitoneal infection. [35] Furthermore, Cef and Euc have been found to be effective in killing and inhibiting bacteria.…”

Section: In Vivo Studymentioning

confidence: 99%

“…[34][35][36] Ren et al showed that macrophages could clear E. coli infection in a mouse model when exposed to intraperitoneal infection. [35] Furthermore, Cef and Euc have been found to be effective in killing and inhibiting bacteria. When the bacteria are eliminated, the number of macrophages was reduced to avoid an overactive inflammatory response.…”

Section: In Vivo Studymentioning

confidence: 99%

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A Versatile Nanoemulsion of Antibiotic and Eucalyptol with Synergistic Effects Against E. Coli Infected Urocystitis

Guo,

Lan,

Qian

et al. 2023

Advanced Therapeutics

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The extensive use and misuse of antibiotics have resulted in bacterial resistance becoming increasing commonplace. Essential oils (EOs) are known to possess antimicrobial properties and therefore have many potential practical applications. However, the default of hydrophobicity, chemical instability, and volatility limit scope of application. Encapsulation of EOs in colloidal delivery systems can mitigate these challenges and allow for greater efficacy. A homogenous nanoemulsion (HS15‐CE) containing a combination of eucalyptol (Euc) and cefradine (Cef) is developed to explore its synergistic effect on antibacterial activity and potentially reduce the amount of antibiotic required to treat bacterial infections. The HS15‐CE nanoemulsion displays a synergistic effect on the inhibition of Escherichia coli (E. coli) growth in vitro, significantly decreasing the minimum inhibitory concentration (MIC) by eight times. The ex vivo imaging reveals high accumulation concentrations and long retention in bladders. Moreover, the nanoemulsion alleviates the E. coli induced cystitis infection, as evidenced by decreased bacterial colonies in urine, reduced inflammatory cytokines, and increased expression of tight junctional protein ZO‐1. These findings suggest the potential of the HS15‐CE nanoemulsion in providing a synergistic effect for the treatment of bacterial urocystitis.

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Section: Resultsmentioning

confidence: 99%