The role of neurotrophic factors in novel, rapid psychiatric treatments

Kim, Jihye; He, Michelle J.; Widmann, Alina K.; Lee, Francis S.

doi:10.1038/s41386-023-01717-x

Cited by 15 publications

(5 citation statements)

References 242 publications

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“…They reported a low proBDNF/BDNF ratio associated with a longer history and higher amount of cocaine use, agreeing with other reports 45 . A lower ratio may be indicative of a BDNF reduced metabolism, possibly related to enzymes and genes modified by cocaine 55 , and they suggest the proBDNF/BDNF ratio as a reliable biomarker for CUD as has been proposed for other psychiatric disorders 56 .…”

Section: Discussionmentioning

confidence: 97%

Peripheral neurotrophin levels during controlled crack/cocaine abstinence: a systematic review and meta-analysis

Morelos-Santana,

Islas-Preciado,

Alcalá-Lozano

et al. 2024

Sci Rep

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Cocaine/crack abstinence periods have higher risk of relapse. Abstinence as initial part of the recovery process is affected by learning and memory changes that could preserve the addictive cycle. To further understand how the interruption of cocaine/crack consumption affects neurotrophin level we performed the present systematic review and meta-analysis following the PRISMA statement (number CRD42019121643). The search formula was conducted in PubMed, Web of Science, Embase, ScienceDirect, and Google Scholar databases. The inclusion criterion was cocaine use disorder in 18 to 60-year-old people, measuring at least one neurotrophin in blood before and after a controlled abstinence period. Studies without pre-post design were excluded. Five investigations had nine different reports, four of them were subjected to a meta-analysis (n = 146). GRADE risk of bias method was followed. Individual studies reported increased peripheral brain derived neurotrophic factor (BDNF) after abstinence, evidence pooled by Hedge’s g showed no significant change in BDNF after abstinence. Relevant heterogeneity in the length of the abstinence period (12–32 days), last cocaine/crack consumption monitoring and blood processing were detected that could help to explain non-significant results. Further improved methods are suggested, and a potential BDNF augmentation hypothesis is proposed that, if true, would help to understand initial abstinence as a re-adaptation period influenced by neurotrophins such as the BDNF.

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Section: Discussionmentioning

confidence: 97%

Peripheral neurotrophin levels during controlled crack/cocaine abstinence: a systematic review and meta-analysis

Morelos-Santana,

Islas-Preciado,

Alcalá-Lozano

et al. 2024

Sci Rep

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show abstract

“…Indeed, with 10 times more cells than neurons, glial cells represent the biggest cellular population in the brain [96][97][98]. These cells play a critical role not only as energetic support for neurons [54][99] [100], but also control of metabolism [101][102], myelination [103][104], formation of the blood-brain barrier (BBB) [105][106], development and remodeling of synapses [107][108][109], regulation of neurotransmitters [110][111][112], control of the fluid/electrolyte homeostasis [113], neuroendocrine function [114] innate immunity response [115] [116], and detoxification [117] [118]. It is not surprising, therefore, that their disruption or dysregulation can lead to neuropsychiatric and neurodegenerative diseases [50][104] [119][120][121][122][123].…”

Section: Glial Cellsmentioning

confidence: 99%

Role of Glial Cells in Depression and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Preprint

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Major depressive disorder (MDD) and substance use disorder (SUD) are of immense medical and social concerns. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, only relatively recently the role of glia in these disorders have attracted attention. Detail understanding of the glial function in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, specific contribution of the neurotrophic factors, neuroinflammation and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes and synantocytes) on phenotypic manifestation of MDD or SUD are emphasized. In addition, potential use of this knowledge in developing novel therapeutics is touched upon.

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“…Finally, regarding the fast-acting antidepressant, ketamine, it was shown that in addition to its role in glutamatergic modulation, as an N-methyl-D-aspartate (NMDA) receptor antagonist, it also promotes BDNF [ 65 , 66 ] sand and possesses anti-neuroinflammatory properties. The latter is manifested through its interaction with the complement system, which is an integral component of the innate immune system and has been implicated in the pathophysiology of depression [ 67 ].…”

Section: Major Depressive Disorder (Mdd)mentioning

confidence: 99%

“…Indeed, glial cells outnumber neurons 10 to 1, representing the biggest cellular population in the brain [ 108 , 109 , 110 ]. These cells play a critical role not only as energetic support for neurons [ 66 , 111 , 112 ], but also in the control of metabolism [ 113 , 114 ], myelination [ 115 , 116 ], formation of the BBB [ 117 , 118 ], development and remodeling of synapses [ 119 , 120 , 121 ], regulation of neurotransmitters [ 122 , 123 , 124 ], control of fluid/electrolyte homeostasis [ 125 ], neuroendocrine function [ 126 ], innate immunity response [ 127 , 128 ], and detoxification [ 129 , 130 ]. It is not surprising, therefore, that their disruption or dysregulation can lead to neuropsychiatric and/or neurodegenerative diseases [ 60 , 116 , 131 ].…”

Section: Glial Cellsmentioning

confidence: 99%

Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

Tizabi,

Getachew,

Hauser

et al. 2024

Brain Sciences

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Mood disorders and substance use disorder (SUD) are of immense medical and social concern. Although significant progress on neuronal involvement in mood and reward circuitries has been achieved, it is only relatively recently that the role of glia in these disorders has attracted attention. Detailed understanding of the glial functions in these devastating diseases could offer novel interventions. Here, following a brief review of circuitries involved in mood regulation and reward perception, the specific contributions of neurotrophic factors, neuroinflammation, and gut microbiota to these diseases are highlighted. In this context, the role of specific glial cells (e.g., microglia, astroglia, oligodendrocytes, and synantocytes) on phenotypic manifestation of mood disorders or SUD are emphasized. In addition, use of this knowledge in the potential development of novel therapeutics is touched upon.

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The role of neurotrophic factors in novel, rapid psychiatric treatments

Cited by 15 publications

References 242 publications

Peripheral neurotrophin levels during controlled crack/cocaine abstinence: a systematic review and meta-analysis

Peripheral neurotrophin levels during controlled crack/cocaine abstinence: a systematic review and meta-analysis

Role of Glial Cells in Depression and Drug Addiction

Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction

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