The Role of Neurovascular System in Neurodegenerative Diseases

Ahmad, Ajmal; Patel, Vanisha; Xiao, Jianfeng; Khan, Mohammad Moshahid

doi:10.1007/s12035-020-02023-z

Cited by 64 publications

(48 citation statements)

References 268 publications

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“…Another significant risk factor for sporadic AD is TBI, especially chronic traumatic encephalopathy ( Van Den Heuvel et al, 2007 ; Stein and Crary, 2020 ). AD is characterized by decreased blood flow in the brain and dysfunction of the neurovascular unit, which likely causes impaired oxygenation ( Ahmad et al, 2020 ; Yu et al, 2020 ). Recent research also suggests that physical exercise can reduce AD risk by improving the brain’s oxygen supply ( De la Rosa et al, 2020 ).…”

Section: Role Of Hif-1α In Neurodegenerative Diseasesmentioning

confidence: 99%

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Митрошина

Savyuk

Ponimaskin

et al. 2021

Front. Cell Dev. Biol.

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Hypoxia is one of the most common pathological conditions, which can be induced by multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body’s adaptation to hypoxia is a highly important phenomenon in both health and disease. Most cellular responses to hypoxia are associated with a family of transcription factors called hypoxia-inducible factors (HIFs), which induce the expression of a wide range of genes that help cells adapt to a hypoxic environment. Basic mechanisms of adaptation to hypoxia, and particularly HIF functions, have being extensively studied over recent decades, leading to the 2019 Nobel Prize in Physiology or Medicine. Based on their pivotal physiological importance, HIFs are attracting increasing attention as a new potential target for treating a large number of hypoxia-associated diseases. Most of the experimental work related to HIFs has focused on roles in the liver and kidney. However, increasing evidence clearly demonstrates that HIF-based responses represent an universal adaptation mechanism in all tissue types, including the central nervous system (CNS). In the CNS, HIFs are critically involved in the regulation of neurogenesis, nerve cell differentiation, and neuronal apoptosis. In this mini-review, we provide an overview of the complex role of HIF-1 in the adaptation of neurons and glia cells to hypoxia, with a focus on its potential involvement into various neuronal pathologies and on its possible role as a novel therapeutic target.

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Section: Role Of Hif-1α In Neurodegenerative Diseasesmentioning

confidence: 99%

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Митрошина

Savyuk

Ponimaskin

et al. 2021

Front. Cell Dev. Biol.

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“…Moreover, astrocytes regulate water transport across the BBB through expression of the water channel aquaporin 4 (AQP4) at their endfeet (22). Thirdly, astrocytes regulate blood flow and nutrient supply to different brain regions through secretion of vasoactive substances (16). As they link the vasculature to neurons in the so-called neurovascular coupling, astrocytes can regulate blood flow based on local neuronal needs (17).…”

Section: The Neurogliovascular Unit Plays a Key Role In Neurodegenerative Disordersmentioning

confidence: 99%

“…Through cytokine release, activated microglia are subsequently responsible for astrocyte activation. These activated astrocytes then produce a neurotoxic factor that finally elicits neuronal cell death responsible for the clinical phenotype (16,26). This nicely illustrates that the different NGVU components, from the BBB to microglia and astrocytes communicate with each other and in concert produce the circumstances for CNS pathology.…”

mentioning

confidence: 99%

The neurogliovascular unit in hepatic encephalopathy

et al. 2021

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Declines in blood ET are not only seen in PD and MCI subjects but also with vascular dementia (manuscript in preparation). Indeed, the vascular endothelium plays a critical role in brain function by maintaining blood-brain barrier permeability and cerebral blood flow, and dysfunction of this system aggravates many neurodegenerative disorders [ 120 , 121 ]. ET administration to human brain microvascular endothelial cells prevented pyrogallol, xanthine/xanthine oxidase or high glucose-induced cell death by protecting against oxidative stress and enhancing the expression of antioxidant enzymes, while decreasing NADPH oxidase 1 (NOX1) expression [ 119 , 122 ].…”

Section: A Gerontological Perspectivementioning

confidence: 99%

Ergothioneine, recent developments

2021

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There has been a recent surge of interest in the unique low molecular weight dietary thiol/thione, ergothioneine. This compound can accumulate at high levels in the body from diet and may play important physiological roles in human health and development, and possibly in prevention and treatment of disease. Blood levels of ergothioneine decline with age and onset of various diseases. Here we highlight recent advances in our knowledge of ergothioneine.

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The Role of Neurovascular System in Neurodegenerative Diseases

Cited by 64 publications

References 268 publications

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

The neurogliovascular unit in hepatic encephalopathy

Ergothioneine, recent developments

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