The role of neutrophils in the development of liver diseases

Xu, Ruonan; Huang, Huihuang; Zhang, Zheng; Wang, Fusheng

doi:10.1038/cmi.2014.2

Cited by 194 publications

(167 citation statements)

References 67 publications

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“…70 A growing amount of evidence suggests that neutrophils play critical roles in chronic inflammatory conditions, such as atherosclerosis, type 2 diabetes, vascular, liver, and intestinal inflammation, and local and systemic allergic reactions. [5][6][7]73,74 Herein, we focus on recent discoveries concerning novel neutrophil functions in infection, autoimmunity, and cancer.…”

Section: Neutrophils In Diseasesmentioning

confidence: 99%

Social networking of human neutrophils within the immune system

Scapini

Cassatella

2014

Blood

353

320

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It is now widely recognized that neutrophils are highly versatile and sophisticated cells that display de novo synthetic capacity and may greatly extend their lifespan. In addition, concepts such as “neutrophil heterogeneity” and “neutrophil plasticity” have started to emerge, implying that, under pathological conditions, neutrophils may differentiate into discrete subsets defined by distinct phenotypic and functional profiles. A number of studies have shown that neutrophils act as effectors in both innate and adaptive immunoregulatory networks. In fact, once recruited into inflamed tissues, neutrophils engage into complex bidirectional interactions with macrophages, natural killer, dendritic and mesenchymal stem cells, B and T lymphocytes, or platelets. As a result of this cross-talk, mediated either by contact-dependent mechanisms or cell-derived soluble factors, neutrophils and target cells reciprocally modulate their survival and activation status. Altogether, these novel aspects of neutrophil biology have shed new light not only on the potential complex roles that neutrophils play during inflammation and immune responses, but also in the pathogenesis of several inflammatory disorders including infection, autoimmunity, and cancer.

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Section: Neutrophils In Diseasesmentioning

confidence: 99%

Social networking of human neutrophils within the immune system

Scapini

Cassatella

2014

Blood

353

320

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“…In common with endothelial cells which express both VCAM-1 and VEGF-Rs, KCs also could express several antigens that functionally regulate the bioactivities of KCs, including cytokine activation and production, cytoskeleton rearrangement, survival, and chemotaxis in liver inflammation [61][62][63][64][65][66][67][68]. The infiltration of neutrophils is commonly seen in all types of liver disease, especially in liver inflammation [69]. Neutrophils also could activate KCs and endothelial cells, leading to upregulation of cellular adhesion molecules such as ICAM-1, VCAM-1, or VAP-1 to induce neutrophils infiltration and endocytose the microbe [70].…”

Section: Kupffer Cells In Infectious Diseasementioning

confidence: 99%

The Biological Function of Kupffer Cells in Liver Disease

Ma¹,

Yang²,

He³

et al. 2017

Biology of Myelomonocytic Cells

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Kupffer cells, which have a characteristic morphology and a kind of phenotype, are the resident macrophages in liver, serve as the largest population mononuclear phagocytes in the body, and are localized in the periportal zone. They have phagocytosis capacity and release all kinds of cytokines, chemokines, and soluble biological mediators. Owing to the different functions of Kupffer cells, they play an important role in liver diseases. In this chapter, we review the role of Kupffer cells in infectious disease, fatty liver disease, liver fibrosis, liver ischemia-reperfusion injury, liver transplantation immunology, as well as liver cancer and metastases.

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“…The liver is an immune tolerant organ with unique predisposition for chronic infections by certain clinically important pathogens (Fahey et al, 2014;Xu et al, 2014;Yang et al, 2014;Zheng et al, 2014). Both pathogenic and protective functions of NK cells in viral infections have been reported (Jost and Altfeld, 2013;Schuch et al, 2014), but it is unclear whether liver trNK cells and cNK cells play similar or distinct roles in anti-viral immune responses.…”

Section: Potential Roles Of Trnk Cells In Liver Diseasesmentioning

confidence: 99%

Tissue-resident natural killer cells in the livers

Peng

Tian

2016

Sci. China Life Sci.

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Nature killer (NK) cells are important lymphocytes of the innate immune system, well known for their pivotal roles in immune surveillance and defense against tumor and virus-infected cells. Current studies have revealed that NK cells are not a homogeneous population, but instead consist of distinct subsets with diverse characteristics. As an organ with predominant innate immunity, the liver is enriched with NK cells, among which two distinct NK cell subsets have recently been identified: conventional NK (cNK) cells and tissue-resident NK (trNK) cells. Liver trNK cells are markedly different from cNK cells in many aspects, representing a new lineage of innate lymphoid cell (ILC) family. Here, we summarize the phenotypic and functional features of liver trNK cells, and review current knowledge regarding developmental pathway of liver trNK cells. We also overview recent advances in human liver trNK cells and discuss the striking shared hallmarks of trNK cells in different tissues.

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The role of neutrophils in the development of liver diseases

Cited by 194 publications

References 67 publications

Social networking of human neutrophils within the immune system

Social networking of human neutrophils within the immune system

The Biological Function of Kupffer Cells in Liver Disease

Tissue-resident natural killer cells in the livers

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