The role of neutrophils in diabetic ulcers and targeting therapeutic strategies

Ma, Xiao-Xuan; Liu, Qing-Kai; Kuai, Le; Ma, Xin; Luo, Yue; Luo, Ying; Song, Jian-Kun; Fei, Xiao-Ya; Jiang, Jing-Si; Wang, Ming-Xia; Shen, Fang; Ru, Yi; Li, Bin

doi:10.1016/j.intimp.2023.110861

International Immunopharmacology

2023

DOI: 10.1016/j.intimp.2023.110861

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The role of neutrophils in diabetic ulcers and targeting therapeutic strategies

Xiao-Xuan Ma,

Qing-Kai Liu,

Le Kuai

et al.

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Cited by 6 publications

References 68 publications

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Promoting Diabetic Wound Healing through a Hydrogel‐Based Cascade Regulation Strategy of Fibroblast‐Macrophage

Jin,

Wang,

Tang

et al. 2024

Adv Healthcare Materials

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The management of diabetic wounds (DWs) continues to pose a significant challenge in the field of medicine. DWs are primarily prevented from healing due to damage to macrophage efferocytosis and fibroblast dysfunction. Consequently, treatment strategy that involve both immunoregulation and the promotion of extracellular matrix (ECM) formation hold promise for healing DWs. Nevertheless, existing treatment methods necessitate complex interventions and are associated with increased costs, for example, the use of cytokines and cell therapy, both of which have limited effectiveness. In this study, a new type of ruthenium (IV) oxide nanoparticles (RNPs)‐laden hybrid hydrogel dressing with a double network of Pluronic F127 and F68 has been developed. Notably, the hybrid hydrogel demonstrates remarkable thermosensitivity, injectability, immunoregulatory characteristics and healing capability. RNPs in hydrogel effectively regulate both fibroblasts and macrophages in a cascade manner, stimulating fibroblast differentiation while synergistically enhancing the efferocytosis of macrophage. The immunoregulatory character of the hydrogel aids in restoring the intrinsic stability of the immune microenvironment in the wound and facilitates essential remodeling of the ECM. This hydrogel therefore offers a novel approach for treating DWs through intercellular communication.This article is protected by copyright. All rights reserved

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Promoting Diabetic Wound Healing through a Hydrogel‐Based Cascade Regulation Strategy of Fibroblast‐Macrophage

Jin,

Wang,

Tang

et al. 2024

Adv Healthcare Materials

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Molecular mechanisms of ubiquitination in wound healing

Zhang,

Gu,

Dai

et al. 2025

Biochemical Pharmacology

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O-GlcNAcylation and immune cell signaling: A review of known and a preview of unknown

Ramakrishnan

2024

Journal of Biological Chemistry

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The role of neutrophils in diabetic ulcers and targeting therapeutic strategies

Cited by 6 publications

References 68 publications

Promoting Diabetic Wound Healing through a Hydrogel‐Based Cascade Regulation Strategy of Fibroblast‐Macrophage

Promoting Diabetic Wound Healing through a Hydrogel‐Based Cascade Regulation Strategy of Fibroblast‐Macrophage

Molecular mechanisms of ubiquitination in wound healing

O-GlcNAcylation and immune cell signaling: A review of known and a preview of unknown

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