The role of nitric oxide on bone metabolism in ovariectomized rats following chronic ethanol intake

Şimşek, Gönül; Uzun, Hafize; Aydın, Seval; Karter, Yesari; Benian, Ali; Dariyerli, Nuran; Kaya, Şennur; Yiğit, Günnür

doi:10.1016/j.lfs.2004.09.034

Cited by 5 publications

(2 citation statements)

References 61 publications

(54 reference statements)

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“…These data are in agreement with [35,36] reported that ovarectomy induced high levels of TNF-α and IL6. Also, [37] found that ovarectomy caused significant increase in tissue level of nitric oxide (NO).…”

Section: Discussionmentioning

confidence: 99%

Isoquercetin Could Protect Against Ovariectomy-Induced Neuronal Changes in Rats

Elnoury¹

2019

Egyptian Journal of Basic and Clinical Pharmacology

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Menopause occurs gradually and is characterized by increased susceptibility to developing mood disorders. Several studies have suggested that oxidative stress is implicated in the subsequent mood changes. It has been reported that quercetin glycosides may be effective due to their antioxidant abilities. The present work aimed to find out whether quercetin able to act against ovariectomy consequences and possible underlying mechanism(s). Animals were randomly divided into six groups of eight rats each. Group (1) Control group (2) Sham operated group (3) Ovariectomized (OVX) group (4) OVX-Isoquercetin-treated (10 mg/kg, i.p., dissolved in a DMSO/saline solution) group (5) OVX-estrogen-treated (subcutaneous implant of pellets (Innovative Research of America, Toledo, OH) containing 17β-estradiol (1.5 mg/8 wk) group (6) OVX-Isoquercetin-estrogen treated group. The treatments were initiated two week after both ovariectomy and sham operations and continued for four consecutive weeks. Tested parameters: oxidative stress markers (MDA, GSH, SOD), inflammatory cytokines (TNF-α, IL-6) and brain monoamines (dopamine, nor epinephrine, 5-HT). Results: Isoquercetin either alone or in combination with estrogen can improve: oxidative stress markers (MDA, GSH, SOD), inflammatory cytokines (TNF-α, IL-6) and brain monoamines (dopamine, nor epinephrine, 5-HT). Combination of both isoquercetin & estrogen gives the best results in most of the tested parameters especially in normalizing IL-6 level. Concerning serotonin estrogen was as good as the combined drugs. Conclusion: Isoquercetin has an additive role with estrogen to maintain healthy brain tissue for production of normal monoamine levels.

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Section: Discussionmentioning

confidence: 99%

Isoquercetin Could Protect Against Ovariectomy-Induced Neuronal Changes in Rats

Elnoury¹

2019

Egyptian Journal of Basic and Clinical Pharmacology

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“…As a prominent gasotransmitter, NO has been demonstrated to influence abundant physiological processes including cell apoptosis, angiogenesis, immune responses, neurotransmission, etc . Therefore, NO has been extensively explored in versatile biomedical applications such as cardiovascular homeostasis, bone metabolism and neurotransmission, respiratory diseases, antimicrobial therapy, wound healing, and antibacterial . Especially, NO can efficiently kill the cancer cells via the nitrosation of mitochondria and DNA, paving the new way for NO‐induced cancer therapy .…”

Section: Nitric Oxide (No)‐generating Ggnsmentioning

confidence: 99%

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

2018

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The fast advances of theranostic nanomedicine enable the rational design and construction of diverse functional nanoplatforms for versatile biomedical applications, among which gas-generating nanoplatforms (GGNs) have emerged very recently as unique theranostic nanoplatforms for broad gas therapies. Here, the recent developments of the rational design and chemical construction of versatile GGNs for efficient gas therapies by either exogenous physical triggers or endogenous disease-environment responsiveness are reviewed. These gases involve some therapeutic gases that can directly change disease status, such as oxygen (O ), nitric oxide (NO), carbon monoxide (CO), hydrogen (H ), hydrogen sulfide (H S) and sulfur dioxide (SO ), and other gases such as carbon dioxide (CO ), dl-menthol (DLM), and gaseous perfluorocarbon (PFC) for supplementary assistance of the theranostic process. Abundant nanocarriers have been adopted for gas delivery into lesions, including poly(d,l-lactic-co-glycolic acid), micelles, silica/mesoporous silica, organosilica, MnO , graphene, Bi Se , upconversion nanoparticles, CaCO , etc. Especially, these GGNs have been successfully developed for versatile biomedical applications, including diagnostic imaging and therapeutic use. The biosafety issue, challenges faced, and future developments on the rational construction of GGNs are also discussed for further promotion of their clinical translation to benefit patients.

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The Effect of Chronic Long-Term Intermittent Hypobaric Hypoxia on Bone Mineral Density in Rats: Role of Nitric Oxide

Güner

Uzun

Yaman

et al. 2013

Biol Trace Elem Res

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Intermittent hypoxia is the most common pattern of hypoxic exposure in humans. The effect of chronic long-term intermittent hypobaric hypoxia (CLTIHH) on bone metabolism is not investigated. We examined the effect of CLTIHH on bone metabolism and the role of nitric oxide (NO) in this process. The rats were divided into three groups in this study. The animals in groups I and II have been exposed to CLTIHH. The animals in group II were also treated with nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester. To obtain CLTIHH, rats were placed in a hypobaric chamber (430 mm Hg; 5 h/day, 5 days/week, 5 weeks). The group III (control) rats breathed room air in the same environment. At the begining of the experiments, bone mineral density (BMD) of the animals were measured, and blood samples were collected from the tail vein. After the 5-week CLTIHH period, the same measurements were repeated. Parathyroid hormone, calcium, phosphate, bone alkaline phosphatase (b-ALP), NO, interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha levels were determined. The cytokines, NO levels, and BMD in CLTIHH-induced rats were higher compared with baseline and control values. The cytokines, b-ALP, and BMD increased while NO levels decreased in the group II compared with baseline values. BMD values of group II were lower than group I but higher than control group. Our results suggested that CLTIHH has positive effects on bone density. Intermittent hypoxia protocols may be developed for treatment and prevention of osteopenia and osteoporosis.

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The role of nitric oxide on bone metabolism in ovariectomized rats following chronic ethanol intake

Cited by 5 publications

References 61 publications

Isoquercetin Could Protect Against Ovariectomy-Induced Neuronal Changes in Rats

Isoquercetin Could Protect Against Ovariectomy-Induced Neuronal Changes in Rats

Gas‐Generating Nanoplatforms: Material Chemistry, Multifunctionality, and Gas Therapy

The Effect of Chronic Long-Term Intermittent Hypobaric Hypoxia on Bone Mineral Density in Rats: Role of Nitric Oxide

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