The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia—Review

Dymara-Konopka, Weronika; Laskowska, Marzena

doi:10.3390/ijms20112757

Cited by 47 publications

(32 citation statements)

References 169 publications

(218 reference statements)

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“…HHcy, as a metabolic disorder parameter, has been considered an independent risk factor for vascularrelated diseases [29,30]. Available evidence shows that HHcy may be a cause of the endothelial dysfunction provoked by oxidative stress, and elevated Hcy levels are significantly associated with preeclampsia [31], preterm birth [32], low birth weight [33], fetal death [34], IUGR [35], and so on.…”

Section: Discussionmentioning

confidence: 99%

Serum homocysteine and folate concentrations in early pregnancy and subsequent events of adverse pregnancy outcome: the Sichuan Homocysteine study

Liu

Luo

Wang

et al. 2020

BMC Pregnancy Childbirth

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Background: Hyperhomocysteinemia may be a risk factor for endothelial dysfunction. Folate and vitamin B12 regulate the homocysteine metabolic process. This study aimed to evaluate the associations between subsequent events of adverse pregnancy outcome and early variables of homocysteine, folate, and vitamin B12 in pregnant women. Methods: This multicenter, retrospective, case-control study involved 563 pregnant women with adverse pregnancy outcome and 600 controls. Adverse pregnancy outcomes included one or more of the following events: preeclampsia, preterm birth, low birth weight, and stillbirth. The associations between subsequent events of adverse pregnancy outcome and early variables of homocysteine, folate, and vitamin B12; metabolic parameters; inflammatory markers; anthropometrics; and lifestyle habits at 11-12 weeks of gestation were analyzed using the logistic regression model. Results: Compared to the lower quartile homocysteine concentrations, the upper quartile homocysteine concentrations were associated with preeclampsia, preterm birth and low birth weight. On the contrary, the lower quartile folate concentrations were associated with preeclampsia, preterm birth and low birth weight compared with the upper quartile folate concentrations. The incidence of adverse pregnancy outcome increased progressively from the first to fourth homocysteine quartiles but decreased progressively from the first to fourth folate quartiles. After adjusting for confounding factors, multivariate logistic regression analysis showed that besides systolic blood pressure, diastolic blood pressure, body mass index and age, homocysteine (IV vs I quartile, aOR 5.89, 95% CI 4.08-8.51, P < 0.001), folate (IV vs I quartile, aOR 0.35, 95% CI 0.25-0.50, P < 0.001), folate supplementation (yes vs no, aOR 0.55, 95% CI 0.35-0.86, P = 0.010) during early pregnancy were independently associated with subsequent events of adverse pregnancy outcome, and vitamin B12 was rejected. Of these, the homocysteine revealed the highest odds ratio in all risk variables, and folate showed the lowest odds ratio in all protective variables.

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Section: Discussionmentioning

confidence: 99%

Serum homocysteine and folate concentrations in early pregnancy and subsequent events of adverse pregnancy outcome: the Sichuan Homocysteine study

Liu

Luo

Wang

et al. 2020

BMC Pregnancy Childbirth

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“…Клинические проявления, которые определяют преэклампсию, представляют собой второй этап заболевания. Хроническая гипоперфузия плаценты вызывает повышение производства и выброс многочисленных биологически актив ных факторов в материнское кровообращение, которые воздействуют на эндотелиоциты и приводят к распространенному эндотелиозу, эндотелиальной дисфункции, генерализованному мультисистемному спазму сосудов, уменьшению объема плазмы, окислительному стрессу и воспалительному состоянию [2][3][4].…”

Section: Introductionunclassified

“…в литературе представлены многочисленные доказательства, что плод развивается в состоянии гипоксии при беременности, ослож ненной преэклампсией. Преэклампсия приводит не только к маточно-плацентарной дисфункции, которая выражается в ограничении роста плода, но и к дисфункции материнского организма (включая почечную, печеночную), а также к гематологическим, неврологическим осложнениям, причем последствия для материнского орга низма могут оказаться долгосрочными [4][5][6].…”

Section: Introductionunclassified

A model for predicting the risk of preeclampsia in women with different somatotypes

et al. 2020

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Hypothesis/aims of study. Preeclampsia is a serious pregnancy-specific multi-organ disease of complex etiology. It affects 36% of expectant mothers worldwide and it persists as a leading cause of maternal and fetal morbidity and mortality. This study aimed at analyzing the frequency of preeclampsia in women with different somatotypes and at developing a prediction model to determine the risk of this disease. Study design, materials and methods. 390 women were examined, of whom 110 were of the macrosomatic type, 173 of the mesosomatic type, and 107 of the microsomatic type. Somatometry was performed according to R.N. Dorokhov in women in early pregnancy (before 910 weeks of gestation). The urinary excretion of markers for podocyte injury (nephrin, podocalyxin, and VEGF) was measured using ELISA spectrophotometric methods. Results. Preeclampsia has been found to be significantly more prevalent among the representatives of the macrosomatic type, compared to women of the meso- and microsomatic types. Urine nephrin, podocalyxin and VEGF levels were significantly higher in women of the macrosomatic type, as compared to those of the meso- and microsomatic types. Using multiple regression analysis, we obtained the regression equation (formula), which predicts the development of preeclampsia in women of different somatotypes. Conclusion. Carrying out calculations according to the presented formula allows predicting the occurrence of preeclampsia with high accuracy, as well as forming high-risk groups among patients already in the first trimester of pregnancy when a pregnant woman is registered in the womens consultation, long before the disease develops. This will contribute to more effective implementation of therapeutic measures to prevent the development of this complication.

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“…The original papers range from new technologies for identifying changes in the maternal system to putative new therapies, the effect of the syndrome on the placenta, rodent models of preeclampsia, effects of the syndrome on the cardiovascular system, sex-specific differences and the effect on the children born from a preeclamptic pregnancy [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. The reviews of this Special Issue range from immunoregulation and macrophages during preeclampsia and molecular targets of therapeutics to trophoblast invasion, uterine blood flow and angiogenesis, they touch on specific protein families and oxidative stress related to preeclampsia, and finally deal with autophagy in preeclampsia and the role of epigenetics in the etiology of the syndrome [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

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confidence: 99%

Special Issue “Molecular and Cellular Mechanisms of Preeclampsia”

Huppertz

2020

IJMS

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The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia—Review

Cited by 47 publications

References 169 publications

Serum homocysteine and folate concentrations in early pregnancy and subsequent events of adverse pregnancy outcome: the Sichuan Homocysteine study

Serum homocysteine and folate concentrations in early pregnancy and subsequent events of adverse pregnancy outcome: the Sichuan Homocysteine study

A model for predicting the risk of preeclampsia in women with different somatotypes

Special Issue “Molecular and Cellular Mechanisms of Preeclampsia”

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