The role of NMDA receptors in neonatal cocaine-induced neurotoxicity

Huber, Jason D.; Darling, S; Park, Kwan-Kyun; Soliman, Karam F.A.

doi:10.1016/s0091-3057(01)00521-4

Cited by 13 publications

(8 citation statements)

References 41 publications

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“…Furthermore, plasticity of glutamatergic synaptic transmission in the VTA is one of the brain adaptations induced by cocaine, and contributes to the development of addictive behaviours (Schilstrom et al, 2006;Wolf, 1998). Changes in the expression of NMDA receptor subunits were observed in the brains of cocaine-exposed rats (Huber et al, 2001;Schilstrom et al, 2006;Yamaguchi et al, 2002;Scheggi et al, 2002). In VTA neurons, cocaine induced an increase in NR1 and NR2B subunit expression and their redistribution to synaptic membranes (Schilstrom et al, 2006).…”

Section: Glutamate and Neuroplasticity -Implications For The Toxicitymentioning

confidence: 99%

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Cunha‐Oliveira

Rego

Oliveira

2008

Brain Research Reviews

198

136

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Section: Glutamate and Neuroplasticity -Implications For The Toxicitymentioning

confidence: 99%

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Cunha‐Oliveira

Rego

Oliveira

2008

Brain Research Reviews

198

136

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“…Mild chronic food restriction (maintaining animals at 90% of their body weight), acute food deprivation (2–24h), and brief cold swim (~5 min) have all been shown to increase the circulating levels of stress hormones (Dallman et al, 1999; Huber et al, 2001; Marinelli et al, 1996), and thereby represent good stress models. Studies using these paradigms have shown that a chronic food restriction increased the action potential output of dopamine cells from approximately 4 spikes/s to 6 spikes/s (Marinelli, 2007).…”

Section: Individual Differences In Dopamine Neuron Activity and Effecmentioning

confidence: 99%

Ethanol and acetaldehyde action on central dopamine systems: mechanisms, modulation, and relationship to stress

Melis

Diana

Enrico

et al. 2009

Alcohol

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There has been a great deal of activity in recent years in the study of the direct effects of ethanol on the dopamine reward system originating in the ventral tegmental area (VTA). In addition, recent evidence suggests that acetaldehyde formed from ethanol in the brain or periphery may be a crucial factor in the central effects of ethanol. This critical review examines the actions of ethanol and acetaldehyde on neurons of the VTA and the possible interactions with stress, with a focus on electrophysiological studies in vivo and in vitro. Ethanol has specific effects on dopamine neurons and there is recent evidence that some of the in vivo and in vitro effects of ethanol are mediated by acetaldehyde. Stress has some analogous actions on neuronal activity in the VTA, and interactions between the effects of stress and alcohol on VTA neurons may be a factor in ethanol-seeking behavior. Taken together, the evidence suggests that stress may contribute to the activating effects of ethanol on dopamine VTA neurons, that at least some actions of ethanol on dopamine VTA neurons are mediated by acetaldehyde, and that interaction between stress and alcohol could play a role in susceptibility to alcoholism. The link between acetaldehyde and ethanol actions on brain reward pathways may provide a new avenue for development of agents to reduce alcohol craving.

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“…The shortening of withdrawal latencies might be explained either by direct effect of MA through maternal breast milk, or by indirect stress-evoking effect of impaired maternal behavior on the pups (Š lamberová et al, 2005a). The only study describing the effects of postnatal psychostimulant (cocaine) on nociceptive thresholds when administrated directly to the pups is that of Huber et al (2001b). However, it should be noted that the thresholds were tested in 30-day-old animals.…”

Section: Discussionmentioning

confidence: 99%

“…Since paw withdrawal reaction is usually linked to supraspinal reflex and tail-flick latency to spinal reflexes, our results suggest supraspinal structures rather than spinal processing to be influenced by the effect of postnatal MA exposure. Different effects of postnatal exposure to cocaine on paw and tail withdrawal latencies were described by Huber et al (2001b) as well. Although there are discrepancies between their and our results, which might be explained by different design as mentioned above, both studies showed that postnatal exposure modulates spinal and supraspinal nociception in a different manner.…”

Section: Discussionmentioning

confidence: 99%

Effect of prenatal and postnatal methamphetamine exposure on nociception in adult female rats

Hrubá

Vaculín²,

Šlamberová

2009

Developmental Psychobiology

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The aim of the present study was to determine effects of methamphetamine (MA) exposure and cross-fostering on thermal nociceptive thresholds in different estrous phases in adult female rats. Rat mothers were exposed daily to injection of MA (5 mg/kg) or saline for 9 weeks: prior to impregnation, throughout gestation and lactation periods. Dams without any injections were used as an absolute control. On postnatal day 1, pups were cross-fostered so that each mother raised four pups of her own and eight pups from the mothers with the other two treatments. Offspring females were tested in adulthood (85-90 days) for thermal nociception as latency [s] of withdrawal reaction of forelimbs, hind limbs, and tail. Our results showed that prenatal MA exposure did not affect the nociception in adulthood, while postnatal MA exposure (i.e., MA administration to lactating mothers) had pro-nociceptive effects. The effect of postnatal MA exposure was apparent in both, fore- and hind limbs, while the latency to tail withdrawal reaction was the same among the groups. In addition, the pro-nociceptive effect of postnatal MA exposure did not depend on estrous cycle. This study indicates that postnatal but not prenatal exposure to MA affects nociception in adult female rats. However, it is still not clear whether the pro-nociceptive effect of postnatal MA exposure is linked to direct action of MA on neuronal organization, or to indirect action of MA mediated by impaired maternal care.

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The role of NMDA receptors in neonatal cocaine-induced neurotoxicity

Cited by 13 publications

References 41 publications

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

Ethanol and acetaldehyde action on central dopamine systems: mechanisms, modulation, and relationship to stress

Effect of prenatal and postnatal methamphetamine exposure on nociception in adult female rats

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