The role of nocturia in the quality of life of men with lower urinary tract symptoms

Abstract

PATIENTS AND METHODSWe retrospectively analysed using multiple regression a large single-centre database of patients receiving routine care for treatment-associated alterations of symptoms and HRQL (assessed at baseline, 2611 men) and 6-12 months after initiation of treatment (1258 men). RESULTSAmong the symptoms assessed using the International Prostate Symptom Score, nocturia (together with urgency and weak stream) had the strongest correlation with HRQL at baseline and after treatment. Watchful waiting, α -blockers, TUMT and TURP reduced nocturia episodes by a mean ( SD ) of 7 (53)%, 17 (40)%, 32 (47)% and 75 (23)%, respectively. The treatmentassociated improvements in nocturia (together with those of weak stream) had the strongest association with those of HRQL. CONCLUSIONSWe conclude that among all LUTS assessed in the IPSS, nocturia has one of the strongest associations with HRQL, and that treatmentassociated improvements in nocturia contribute considerably to overall improvements in HRQL. KEYWORDSBPH, nocturia, quality of life, TURP, transurethral microwave thermotherapy, α 1 -adrenoceptor antagonist Study Type -Symptom prevalence (retrospective cohort) Level of Evidence 2b OBJECTIVESTo determine the role of treatmentassociated improvement in nocturia in health-related quality of life (HRQL) in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia, and secondarily to confirm the role of nocturia in HRQL at baseline and to compare the effects of watchful waiting, transurethral microwave treatment (TUMT) and transurethral resection of the prostate (TURP) to those of α 1 -adrenoceptor antagonists ( α -blockers) on nocturia.

The impact of adding low-dose oral desmopressin therapy to tamsulosin therapy for treatment of nocturia owing to benign prostatic hyperplasia

“…BPH is a common disorder, which affect almost 40 % of men older than 50 years [4]. In elderly, BPH is considered the most common cause of nocturia, that is, not only inconvenient but can also have a marked effect on sleep patterns and decreases the Qol [8,9]. Different treatment modalities for lUtS/BPH have been used with success.…”

Nocturia: Current Levels of Evidence and Recommendations From the International Consultation on Male Lower Urinary Tract Symptoms

“…More evidence is needed before NSAID therapy can be recommended for therapy of nocturia (GOR C). 4 Surgical Interventions for Benign Prostatic Enlargement Van Dijk et al 32 retrospectively analyzed 1258 men who had undergone various treatments for LUTS suggestive of BPE, including watchful waiting, alpha-blockers, transurethral resection of prostate (TURP), and transurethral needle ablation. After 6-12 months of follow-up, the various modalities improved nocturia by 7%, 17%, 75%, and 32%, respectively (LOE 3).…”

Relationship Between Anxiety and Lower Urinary Tract Symptoms

“…The results of the Kayhan's study support that anxiety and depressive impairments are found with a high incidence in patients with respiratory disorders [20]. Previous studies have consistently informed on the negative effect of LUTS on the health-related quality of life (HRQoL) of men with BPH [21,22]. It is believed that accomplished management of BPH is a cooperative endeavor between healthcare professionals and the patient purpose at decreasing the influence of LUTS on the HRQoL of patients with BPH [23].…”