The role of non-coding genome in the behavior of infiltrated myeloid-derived suppressor cells in tumor microenvironment; a perspective and state-of-the-art in cancer targeted therapy

Shabgah, Arezoo Gowhari; Salmaninejad, Arash; Thangavelu, Lakshmi; Марков, А. В.; Yumashev, Alexei Valerievich; Goleij, Pouya; Hedayati-Moghadam, Mahdiyeh; Mohammadi, Hamed; Ahmadi, Majid; Navashenaq, Jamshid Gholizadeh

doi:10.1016/j.pbiomolbio.2020.11.006

Cited by 11 publications

(10 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous studies, negative roles of miRNAs on MDSCs have been described (14). In tumor-bearing mice, miR-223 reduces the accumulation of MDSCs and inhibits immature myeloid cells differentiation into MDSCs by targeting Myocyte enhancer factor 2C (MEF2C) (36,48). In ovarian cancer treatment, Lin et al found that dexamethasone(DEX), a synthetic glucocorticoid (GC), stimulated miR-708 overexpression by targeting RaP1B, further diminishing the expansion and number of MDSCs in TME (53).…”

Section: Expansion Of Mdscsmentioning

confidence: 98%

“…Researchers have found that the interactions between miRNAs/LncRNAs and transcription factor modulated the biological status and immune activity of MDSCs in TME ( 36 ). Here, we describe the regulation of miRNA/lncRNA on MDSCs in the TME.…”

Section: Post-transcriptional Regulation Of Tumor Mdscs With Mirnas/l...mentioning

confidence: 99%

Section: Post-transcriptional Regulation Of Tumor Mdscs With Mirnas/l...mentioning

confidence: 99%

“…MiR-9 and or Runx1 overlapping RNA (RUNXOR) are two non-coding RNAs involved in the differentiation and activation of MDSCs. Tian et al showed that miR-9 directly downregulated the expression of lncRNA Runx to stimulate the differentiation of MDSCs and reduce the suppressive ability of MDSCs (36). The retinal non-coding RNA3 (RNCR3), an intragenic lncRNA, which is conserved sequence in mammalian genomes, has been shown to be highly expressed in glioblastoma and prostate cancer (91).…”

Section: Lncrna/mirna Interaction Regulate Mdscs In Tmementioning

confidence: 99%

See 3 more Smart Citations

MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

et al. 2022

View full text Add to dashboard Cite

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature cells derived from bone marrow that play critical immunosuppressive functions in the tumor microenvironment (TME), promoting cancer progression. According to base length, Non-coding RNAs (ncRNAs) are mainly divided into: microRNAs (miRNAs), lncRNAs, snRNAs and CircRNAs. Both miRNA and lncRNA are transcribed by RNA polymerase II, and they play an important role in gene expression under both physiological and pathological conditions. The increasing data have shown that MiRNAs/LncRNAs regulate MDSCs within TME, becoming one of potential breakthrough points at the investigation and treatment of cancer. Therefore, we summarize how miRNAs/lncRNAs mediate the differentiation, expansion and immunosuppressive function of tumor MDSCs in TME. We will then focus on the regulatory mechanisms of exosomal MicroRNAs/LncRNAs on tumor MDSCs. Finally, we will discuss how the interaction of miRNAs/lncRNAs modulates tumor MDSCs.

show abstract

Section: Expansion Of Mdscsmentioning

confidence: 98%

Section: Post-transcriptional Regulation Of Tumor Mdscs With Mirnas/l...mentioning

confidence: 99%

Section: Post-transcriptional Regulation Of Tumor Mdscs With Mirnas/l...mentioning

confidence: 99%

Section: Lncrna/mirna Interaction Regulate Mdscs In Tmementioning

confidence: 99%

See 2 more Smart Citations

MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Meanwhile, an increasing number of studies have emphasized the role of noncoding RNAs in remodeling the tumor microenvironment, which is involved in the immune cell differentiation trajectory, function and infiltration [ 188 – 194 ].…”

Section: Noncoding Rnas Regulate Both Tumor Metabolism and The Immune Microenvironmentmentioning

confidence: 99%

Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers

et al. 2021

View full text Add to dashboard Cite

Altered metabolic patterns in tumor cells not only meet their own growth requirements but also shape an immunosuppressive microenvironment through multiple mechanisms. Noncoding RNAs constitute approximately 60% of the transcriptional output of human cells and have been shown to regulate numerous cellular processes under developmental and pathological conditions. Given their extensive action mechanisms based on motif recognition patterns, noncoding RNAs may serve as hinges bridging metabolic activity and immune responses. Indeed, recent studies have shown that microRNAs, long noncoding RNAs and circRNAs are widely involved in tumor metabolic rewiring, immune cell infiltration and function. Hence, we summarized existing knowledge of the role of noncoding RNAs in the remodeling of tumor metabolism and the immune microenvironment, and notably, we established the TIMELnc manual, which is a free and public manual for researchers to identify pivotal lncRNAs that are simultaneously correlated with tumor metabolism and immune cell infiltration based on a bioinformatic approach.

show abstract

Designing new nanoliposomal formulations and evaluating their effects on myeloid‐derived suppressor cells and regulatory T cells in a colon cancer model aiming to develop an efficient delivery system for cancer treatment; an in vitro and in vivo study

Taheri

Bahramifar

Jaafari

et al. 2021

Biotech and App Biochem

View full text Add to dashboard Cite

Regulfatory T cells (Tregs) and myeloid‐derived suppressor cells (MDSCs) are common immunosuppressive cells in the tumor microenvironment. These cells, through various mechanisms, inhibit antitumor immune responses and impede effective therapies. Therefore, designing an efficient protocol for inducing immune surveillance in tumors is highly recommended. Recently, nanoliposomes have provided broad‐spectrum and state‐of‐the‐art vehicles to deliver antigens or immune system compartments in immunotherapies. It has been shown that different lipids in the structure of liposomes and various liposomal formulations can affect immune responses in the tumor microenvironment. This study was aimed to evaluate the effects of four different liposomal formulations on MDSCs and Tregs in C26 tumor‐bearing mice. To this end, after preparing liposomes, they were injected into tumor‐inoculated mice and analyzed MDSC and Treg population and functions in spleen and tumor tissues. Results showed that 1,2‐dioleoyl‐3‐trimethylammonium propane (DOTAP)‐containing liposomes reduced MDSC population and activity in the spleen, but not tumor, compared with other groups significantly (p < 0.05 and p < 0.01, respectively). Moreover, DOTAP‐containing liposomes reduced the expression of S100A8 and arginase‐1 genes in splenic MDSCs (p < 0.05). In conclusion, we provided evidence that DOTAP‐containing liposomes contributed to stimulating immune responses and provided a situation to inhibit immunosuppression in the tumor microenvironment.

show abstract

The role of non-coding genome in the behavior of infiltrated myeloid-derived suppressor cells in tumor microenvironment; a perspective and state-of-the-art in cancer targeted therapy

Cited by 11 publications

References 89 publications

MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

MicroRNAs/LncRNAs Modulate MDSCs in Tumor Microenvironment

Noncoding RNAs link metabolic reprogramming to immune microenvironment in cancers

Designing new nanoliposomal formulations and evaluating their effects on myeloid‐derived suppressor cells and regulatory T cells in a colon cancer model aiming to develop an efficient delivery system for cancer treatment; an in vitro and in vivo study

Contact Info

Product

Resources

About