The Role of Non-Coding RNAs in Glioma

Goenka, Anshika; Tiek, Deanna; Song, Xian‐Rong; Iglesia, Rebeca Piatniczka; Lu, Minghui; Hu, Bo; Cheng, Shi‐Yuan

doi:10.3390/biomedicines10082031

Cited by 21 publications

(10 citation statements)

References 199 publications

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“…LncRNAs are RNA molecules longer than 200 nucleotides that do not carry protein coding capacity [ 49 ]. Several lncRNAs have been shown to be crucial players in different cancers [ 50 , 51 , 52 , 53 ] and many of them are considered as new biomarkers [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells

Jacksi

Schád

Buday

et al. 2023

IJMS

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Tks4 is a large scaffold protein in the EGFR signal transduction pathway that is involved in several cellular processes, such as cellular motility, reactive oxygen species-dependent processes, and embryonic development. It is also implicated in a rare developmental disorder, Frank–ter Haar syndrome. Loss of Tks4 resulted in the induction of an EMT-like process, with increased motility and overexpression of EMT markers in colorectal carcinoma cells. In this work, we explored the broader effects of deletion of Tks4 on the gene expression pattern of HCT116 colorectal carcinoma cells by transcriptome sequencing of wild-type and Tks4 knockout (KO) cells. We identified several protein coding genes with altered mRNA levels in the Tks4 KO cell line, as well as a set of long non-coding RNAs, and confirmed these changes with quantitative PCR on a selected set of genes. Our results show a significant perturbation of gene expression upon the deletion of Tks4, suggesting the involvement of different signal transduction pathways over the well-known EGFR signaling.

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Section: Resultsmentioning

confidence: 99%

Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells

Jacksi

Schád

Buday

et al. 2023

IJMS

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“…Glioblastoma is the most common primary malignant tumor of the adult central nervous system, accounting for ~80% of all malignant brain tumors ( 77). An increasing number of studies have found that circRNAs are differentially expressed in glioblastoma and participate in the occurrence and development of glioblastoma by acting as miRNA sponges and encoding proteins (78,79). In glioblastoma, circRNAs have been identified that may encode proteins of peptides, and these may fulfill certain roles in the occurrence and development of glioblastoma.…”

Section: Circrna-encoded Proteins and Gastric Cancer (Gc)mentioning

confidence: 99%

Advances in the protein‑encoding functions of circular RNAs associated with cancer (Review)

Yuan

Zhang²,

Cong

2023

Oncol Rep

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Circular RNAs (circRNAs) are a special class of non-coding RNAs that are widely expressed in tissues and cells. Owing to their lack of a 5'-cap and 3'-polyadenylated [poly(A)] tail, they are more structurally stable and difficult to degrade compared with linear RNA. Numerous studies published recently have suggested that circRNAs can encode peptides or proteins through cap-independent translation mechanisms and participate in the occurrence and development of cancer. In the present review, the translation mechanism underlying the encoding of proteins by circRNAs, the biological information tools that are available for predicting translation, and the identification and verification of their translational abilities are summarized and analyzed. Finally, the mechanisms associated with circRNA-encoded proteins or polypeptides in various types of cancer are summarized. In this review and its discussion on circRNAs and their coding function, we hope to provide novel perspectives and possibilities for the treatment of cancer as knowledge in this area is added to and developed in the future. Contents 1. Introduction 2. Translational mechanisms of circRNAs 3. Bioinformatics tools for the analysis of circRNA-encoded proteins 4. Role of circRNA-encoded proteins in cancer 5. Concluding remarks

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“…Faulty events during the biogenesis of miRNAs can lead to their deregulation in many cancers. Such events include amplifications, deletions, epigenetic modifications, translocations, and silencing of miRNAs [38].…”

Section: Mirnas As Biomarkers Within Glioblastomasmentioning

confidence: 99%

MicroRNA Biomarkers in Primary Brain Malignancies

Mustafov¹,

Seriah²,

Malik³

et al. 2023

Epigenetics - Regulation and New Perspectives

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Despite the concerted efforts within the management of brain malignancies over the past few decades, primary brain cancers remain an obscure challenge with unfavourable outcomes for the patients. Glioblastomas (GBM) and medulloblastomas afford the most prevalent brain tumours and account for markedly high mortality rates within affected patients. The unmet clinical requirements for an early diagnostic biomarker and effective treatment have shed light onto microRNAs (miRNAs). These are small, endogenous noncoding RNAs involved in a wide spectrum of biological processes, such as post-translational modification, tumorigenesis, angiogenesis, invasiveness, and apoptosis. Increased expression of miR-21 has been shown to have devastating effects upon patients with brain tumours, and it could be used as a diagnostic biomarker and an early relapse indicator. miRNAs such as miR-128a, miR-34a, miR-7 and miR-1253 have demonstrated tumour suppressive properties and could serve as putative therapeutic agents. MiRNA signatures, such as miR-21 and miR-10b could be incorporated as potential prognostic indicators for advanced and metastatic brain malignancies, whereas miR-221/222 cluster has a therapeutic potential to sensitise cancerous cells towards radiotherapy. Herein, we summarised current knowledge on how miRNAs with significant role in glioblastomas and medulloblastomas specifically can be effectively used as promising brain cancer diagnostics, prognostics, and therapeutics.

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The Role of Non-Coding RNAs in Glioma

Cited by 21 publications

References 199 publications

Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells

Absence of Scaffold Protein Tks4 Disrupts Several Signaling Pathways in Colon Cancer Cells

Advances in the protein‑encoding functions of circular RNAs associated with cancer (Review)

MicroRNA Biomarkers in Primary Brain Malignancies

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