The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells

Ghafouri‐Fard, Soudeh; Shoorei, Hamed; Anamag, Farhad Tondro; Taheri, Mohammad

doi:10.3389/fonc.2020.608975

Cited by 73 publications

(42 citation statements)

References 175 publications

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“…Based on accumulating evidence, aberrantly expressed lncRNAs in tumours perform significant functions in oncogenesis and cancer progression ( 24 – 26 ). Extensive lncRNAs are aberrantly expressed in NPC and participate in the malignant processes of NPC ( 27 – 29 ).…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA SLC9A3‑AS1 increases E2F6 expression by sponging microRNA‑486‑5p and thus facilitates the oncogenesis of nasopharyngeal carcinoma

Zhang

et al. 2021

Oncol Rep

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Long noncoding RNA SLC9A3 antisense RNA 1 (SLC9A3-AS1) plays a central role in lung cancer; yet, its functions in nasopharyngeal carcinoma (NPC) have not been elucidated. The present study revealed the roles of SLC9A3-AS1 in NPC and dissected the mechanisms downstream of SLC9A3-AS1. SLC9A3-AS1 levels in NPC were assessed by applying RT-qPCR. The modulatory role of SLC9A3-AS1 interference on NPC cells was examined using numerous functional experiments. High expression of SLC9A3-AS1 was observed in NPC samples. Patients with NPC with a high level of SLC9A3-AS1 experienced a shorter overall survival than those with a low SLC9A3-AS1 level. Loss of SLC9A3-AS1 reduced NPC cell proliferation, colony formation, migration, and invasion but induced cell apoptosis in vitro . Animal experiments further revealed that the depletion of SLC9A3-AS1 hindered NPC tumour growth in vivo . As a competitive endogenous RNA, SLC9A3-AS1 sponged microRNA-486-5p (miR-486-5p), consequently upregulating E2F transcription factor 6 (E2F6). Finally, the effects of SLC9A3-AS1 silencing on NPC cells were reversed by inhibiting miR-486-5p or overexpressing E2F6. In summary, SLC9A3-AS1 exerted carcinogenic effects on NPC cells by adjusting the miR-486-5p/E2F6 axis. Accordingly, the newly identified SLC9A3-AS1/miR-486-5p/E2F6 pathway may offer attractive therapeutic targets for future development.

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Section: Discussionmentioning

confidence: 99%

Long noncoding RNA SLC9A3‑AS1 increases E2F6 expression by sponging microRNA‑486‑5p and thus facilitates the oncogenesis of nasopharyngeal carcinoma

Zhang

et al. 2021

Oncol Rep

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“…It has been well documented that ncRNAs, including miRNAs, lncRNAs, and circular RNAs (circRNAs), participated in regulation of gene expression by talking with each other through the ceRNA mechanism. [18][19][20][21][22] To explore the upstream regulatory miRNAs of SEMA3F, we introduced seven prediction programs, involving PITA, RNA22, miRmap, microT, miRanda, PicTar, and TargetScan, to predict possible miRNAs that could potentially bind to SEMA3F. At the end, 13 miRNAs were finally obtained.…”

Section: Discussionmentioning

confidence: 99%

ncRNAs-mediated high expression of SEMA3F correlates with poor prognosis and tumor immune infiltration of hepatocellular carcinoma

Lou

Wang

Chen

et al. 2021

Molecular Therapy - Nucleic Acids

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Hepatocellular carcinoma (HCC) is notorious for its poor prognosis. Increasing evidence has demonstrated that semaphorin 3F (SEMA3F) plays key roles in initiation and progression of several types of human cancer. However, the specific role and mechanism of SEMA3F in HCC remains not fully determined. In this study, we first performed pan-cancer analysis for SEMA3F's expression and prognosis using The Cancer Genome Atlas (TCGA) and The Genotype-Tissue Expression (GTEx) data and found that SEMA3F might be a potential oncogene in HCC. Subsequently, noncoding RNAs (ncRNAs) contributing to SEMA3F overexpression were identified by a combination of a series of in silico analyses, including expression analysis, correlation analysis, and survival analysis. Finally, the TMPO-AS1/SNHG16-let-7c-5p axis was identified as the most potential upstream ncRNA-related pathway of SEMA3F in HCC. Moreover, SEMA3F level was significantly positively associated with tumor immune cell infiltration, biomarkers of immune cells, and immune checkpoint expression. Collectively, our findings elucidated that ncRNAs-mediated upregulation of SEMA3F correlated with poor prognosis and tumor immune infiltration in HCC.

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“…Other epigenetic regulators, including small non-coding microRNA, have also been postulated to contribute to the pathogenesis of tumor initiation among patients with MEN1. MicroRNA is known to contribute to multiple cellular processes, including cell proliferation, adhesion, cell death and differentiation (52) and negatively regulate post-transcriptional gene expression (53). One study evaluated parathyroid adenomas in MEN1 and suggests three main dysregulated microRNA: miR-1301, miR-4258 and miR-664.…”

Section: Multiple Endocrine Neoplasia Type 1 Syndrome (Men1)mentioning

confidence: 99%

Familial Hyperparathyroidism

Blau

Simonds

2021

Front. Endocrinol.

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Regulation of the serum calcium level in humans is achieved by the endocrine action of parathyroid glands working in concert with vitamin D and a set of critical target cells and tissues including osteoblasts, osteoclasts, the renal tubules, and the small intestine. The parathyroid glands, small highly vascularized endocrine organs located behind the thyroid gland, secrete parathyroid hormone (PTH) into the systemic circulation as is needed to keep the serum free calcium concentration within a tight physiologic range. Primary hyperparathyroidism (HPT), a disorder of mineral metabolism usually associated with abnormally elevated serum calcium, results from the uncontrolled release of PTH from one or several abnormal parathyroid glands. Although in the vast majority of cases HPT is a sporadic disease, it can also present as a manifestation of a familial syndrome. Many benign and malignant sporadic parathyroid neoplasms are caused by loss-of-function mutations in tumor suppressor genes that were initially identified by the study of genomic DNA from patients who developed HPT as a manifestation of an inherited syndrome. Somatic and inherited mutations in certain proto-oncogenes can also result in the development of parathyroid tumors. The clinical and genetic investigation of familial HPT in kindreds found to lack germline variants in the already known HPT-predisposition genes represents a promising future direction for the discovery of novel genes relevant to parathyroid tumor development.

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The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells

Cited by 73 publications

References 175 publications

Long noncoding RNA SLC9A3‑AS1 increases E2F6 expression by sponging microRNA‑486‑5p and thus facilitates the oncogenesis of nasopharyngeal carcinoma

Long noncoding RNA SLC9A3‑AS1 increases E2F6 expression by sponging microRNA‑486‑5p and thus facilitates the oncogenesis of nasopharyngeal carcinoma

ncRNAs-mediated high expression of SEMA3F correlates with poor prognosis and tumor immune infiltration of hepatocellular carcinoma

Familial Hyperparathyroidism

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