The Role of Non-coding RNAs in Diabetic Nephropathy-Related Oxidative Stress

Abstract

Diabetic nephropathy (DN) is one of the main complications of diabetes and the main cause of diabetic end-stage renal disease, which is often fatal. DN is usually characterized by progressive renal interstitial fibrosis, which is closely related to the excessive accumulation of extracellular matrix and oxidative stress. Non-coding RNAs (ncRNAs) are RNA molecules expressed in eukaryotic cells that are not translated into proteins. They are widely involved in the regulation of biological processes, such as, chromatin remodeling, transcription, post-transcriptional modification, and signal transduction. Recent studies have shown that ncRNAs play an important role in the occurrence and development of DN and participate in the regulation of oxidative stress in DN. This review clarifies the functions and mechanisms of ncRNAs in DN-related oxidative stress, providing valuable insights into the prevention, early diagnosis, and molecular therapeutic targets of DN.

LncRNA MALAT1 Aggravates Renal Tubular Injury via Activating LIN28A and the Nox4/AMPK/mTOR Signaling Axis in Diabetic Nephropathy

“…Long non-coding RNAs (lncRNAs) are key regulators in DN (6,7). For instance, Ge et al reported that lncRNA NR_038323 alleviated renal fibrosis via sponging miR-324-3p and inactivating p38MAPK and ERK1/2 pathways (8).…”

Biochemical Investigation of Therapeutic Potentials of Plant-Based Bioactive Compounds as Stimulators of Glucagon like peptide-1 Secretion

“…Interestingly, many recent studies have investigated the antioxidant and anti-inflammatory effects of these inhibitors. 6 - 13 …”

“…Interestingly, many recent studies have investigated the antioxidant and antiinflammatory effects of these inhibitors. [6][7][8][9][10][11][12][13] Further, many antioxidants, anti-inflammatory, and antiinfective bioactive compounds have been studied to be effective biocontrols against animal and human diseases including zoonotic conditions of intestine. 3,[14][15][16][17][18] Nevertheless, antioxidants are mostly present in fruits and vegetable and possess great potential against oxidative damage.…”

Peripheral Blood circRNA Microarray Profiling Identities hsa_circ_0001831 and hsa_circ_0000867 as Two Novel circRNA Biomarkers for Early Type 2 Diabetic Nephropathy

“…[6][7][8] The pathological manifestations associated with DN include glomerular thylakoid cells hypertrophy and hyperplasia, extracellular matrix (ECM) accumulation, podocytes function impairment and renal fibrosis. 9,10 Some studies have been partially demonstrated that circRNAs can act as microRNA sponges to influence the pathogenesis of DN, for instance, An et al have shown that hsa_circ_0003928 can bind to miR-151-3p and moderate Annexin A2 (ANXA2) expression via the microRNAs sponge, thereby attenuating high glucose-induced apoptosis in podocytes and glomerular thylakoid cells. 11 circRNA_0080425 is able to target miR-24-3p to regulate fibroblast growth factor 11 (FGF11) expression levels, which led to fibrosis and promoted DN progression.…”