2022
DOI: 10.3390/cells11091588
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The Role of Non-Coding RNAs in the Human Placenta

Abstract: Non-coding RNAs (ncRNAs) play a central and regulatory role in almost all cells, organs, and species, which has been broadly recognized since the human ENCODE project and several other genome projects. Nevertheless, a small fraction of ncRNAs have been identified, and in the placenta they have been investigated very marginally. To date, most examples of ncRNAs which have been identified to be specific for fetal tissues, including placenta, are members of the group of microRNAs (miRNAs). Due to their quantity, … Show more

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Cited by 13 publications
(8 citation statements)
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“…The poor recovery of cardiac function following heart tissue injury and the lack of effective strategies facilitating this recovery in clinical settings emphasize the importance of preventative monitoring and diagnosis [ 146 ]. Ex-ncRNAs, selectively released by different cells, play versatile roles in numerous biological processes and diseases [ 147 ]. Recently, studies elucidating the Ex-ncRNAs-mediated intercellular crosstalk in the pathogenesis of various CVDs are emerging [ 148 ], and Ex-ncRNAs are increasingly recognized as promising diagnostic biomarkers and druggable targets [ 149 , 150 ].…”
Section: Discussionmentioning
confidence: 99%
“…The poor recovery of cardiac function following heart tissue injury and the lack of effective strategies facilitating this recovery in clinical settings emphasize the importance of preventative monitoring and diagnosis [ 146 ]. Ex-ncRNAs, selectively released by different cells, play versatile roles in numerous biological processes and diseases [ 147 ]. Recently, studies elucidating the Ex-ncRNAs-mediated intercellular crosstalk in the pathogenesis of various CVDs are emerging [ 148 ], and Ex-ncRNAs are increasingly recognized as promising diagnostic biomarkers and druggable targets [ 149 , 150 ].…”
Section: Discussionmentioning
confidence: 99%
“…NcRNAs are a class of non-protein-coding RNAs, which mainly include miRNAs, circulating long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Among them, numerous studies have demonstrated that miRNAs regulate the function of trophoblast cells through different targets in pregnancy and thus participate in the occurrence and development of pregnancy disorders, while the application of lncRNAs and circRNAs in the regulation of trophoblast cell function is relatively rare [ 192 ]. In addition, miRNAs are specifically expressed according to various tissues, which can be directly collected from maternal blood samples and the content is relatively stable [ 56 , 193 ].…”
Section: Discussionmentioning
confidence: 99%
“…It is interesting to note that the differential expression of lncRNA and circRNA is closely related to the occurrence and development of pregnancy disorders [ 190 , 191 , 194 ]. For example, so far, lncRNA H19 (H19) is one of the most thoroughly studied lncRNAs [ 195 ], and H19 is closely related to the occurrence and development of PE and IUGR [ 192 , 196 , 197 ]. Compared with normal pregnant women, patients with early RSA have 123 differentially expressed circRNAs, of which 78 are up-regulated and 45 are down-regulated, but the specific mechanism remains unclear [ 191 ].…”
Section: Discussionmentioning
confidence: 99%
“…And the expression of lncRNA RP11 (lncRNA RP11-290L1.3) from cord blood was positively correlated with birth weight ( r = 0.8003, P < 0.01) ( 141 ). In addition, ncRNAs have multiple roles in the human placenta which connects mother and fetus, such as regulating trophoblast proliferation and differentiation, and affecting insulin secretion and regulation [reviewed in Žarković et al ( 142 )]. Thus, ncRNA expression may predict the fetal birth weight and metabolic risks in later life ( Tables 2 , 3 ).…”
Section: Role Of Ncrnas In Abnormal Birth Weight In Offspringmentioning
confidence: 99%