The role of non‐coding RNAs in fibroblast‐like synoviocytes in rheumatoid arthritis

Abstract

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by synovial hyperplasia, and fibroblast‐like synoviocytes (FLSs) constitute the majority of cells in the synovial tissue, playing a crucial role in the onset of RA. Dysregulation of FLSs function is a critical strategy in treating joint damage associated with RA. Non‐coding RNAs, a class of RNA molecules that do not encode proteins, participate in the development of various diseases. This article aims to review the progress in the study of long non‐coding RNAs, microRNAs, and circular RNAs in FLSs. Non‐coding RNAs are involved in the pathogenesis of RA, directly or indirectly regulating FLSs' proliferation, migration, invasion, apoptosis, and inflammatory responses. Furthermore, non‐coding RNAs also influence DNA methylation and osteogenic differentiation in FLSs. Therefore, non‐coding RNAs hold promise as biomarkers for diagnosing RA. Targeting non‐coding RNAs in FLSs locally represents a potential strategy for future therapies in RA.