The role of non-HLA gene polymorphisms in graft-versus-host disease

Graft-versus-Host Disease after HLA-Matched Sibling Bone Marrow or Peripheral Blood Stem Cell Transplantation: Comparison of North American Caucasian and Japanese Populations

“…Although the main determinant of GVHD occurrence is the major histocompatibility antigen,[20] occurrence of GVHD in transplantation from an HLA-identical sibling indicates that non-HLA gene polymorphisms play an important role in GVHD. [21] Candidate gene studies have shown that various gene polymorphisms in recipients and donors are associated with GVHD. [21] Furthermore, the genome-wide association study confirms that some gene polymorphisms such as IL-2, IL-6, CTLA4, HPSE , and MTHFR are responsible for GVHD.…”

Toll-like receptor 1 variation increases the risk of transplant-related mortality in hematologic malignancies

“…Underlined and bold results represent P b 0.05. To the best of our knowledge, this is the first report identifying the same genotype of a single nucleotide variation in both the recipients and donors as having similar impacts on transplant outcomes among single nucleotide variations previously known to be significant [25][26][27][28][29][30]. This could result from the inherent nature of TLR1, which is ubiquitously expressed in various tissues such as white blood cells, lymph nodes, endothelium, lung, gut, skin, and liver, and plays critical roles in antimicrobial immunity [1,2].…”

Prophylactic and therapeutic treatment of graft-versus-host disease in Japan

“…In particular, HSCT is very different in Japan than in Western countries, in that, in Japan: most transplant physicians prefer bone marrow transplantation (BMT) to peripheral blood stem cell transplantation (PBSCT), especially in unrelated donor transplantation; cord blood transplantation (CBT) with a single cord unit is performed withchronic GVHD that have been conducted in Japan. Articles regarding the pathogenesis of GVHD, the effects of human leukocyte antigen (HLA) and non-HLA gene polymorphisms on GVHD, and the prediction of GVHD by biomarkers are excluded, because excellent review articles have been published in this journal [6][7][8][9]. Valuable research outcomes have been reported from Japan as well as other countries.…”