The Role of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Treatment of Patients With Hepatic Disease: A Review Article

Soleimanpour, Maryam; Imani, Farnad; Safari, Saeid; Sanaie, Sarvin; Soleimanpour, Hassan; Ameli, Hoorolnesa; Alavian, Seyed Moayed

doi:10.5812/aapm.37822

Cited by 25 publications

(27 citation statements)

References 63 publications

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“…Many anti-inflammatory drugs, particularly nonsteroidal anti-inflammatory drugs (NSAIDs) are broadly used for controlling inflammation. However, the widespread use of NSAIDs increases the risk of adverse effects, such as gastrointestinal and kidney problems [29]. Therefore, study of natural products with anti-inflammatory activity has increased in the recent years.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effect of <i>o</i>-Vanillic Acid on Lipopolysaccharide-Stimulated Macrophages and Inflammation Models

Lee¹,

Lee²,

Shin³

et al. 2018

JFNR

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Inflammation is an important biological reaction in the body in response to external stimuli. Excessive inflammation causes various inflammatory disorders such as allergic hypersensitivity, autoimmune disease, rheumatoid arthritis, and cancer. Macrophages play a major role in the inflammatory response by producing inflammatory mediators such as nitric oxide, prostaglandin E 2 , and pro-inflammatory cytokines. Natural products are often a source of bioactive compounds, which have great potential as novel therapeutic agents. Amomum xanthoides extract has been shown to possess various pharmacological activities including anti-inflammatory activity. This study evaluated the anti-inflammatory potential of o-vanillic acid (o-VA), a major compound in A. xanthoides, using lipopolysaccharide (LPS)-induced macrophages and in vivo animal models. o-VA decreased, in a concentration-dependent manner, the LPS-induced gene expression and production of inflammatory mediators, such as inducible nitric oxidase/cyclooxygenase-2 and pro-inflammatory cytokines, by reducing the nuclear factor-κB activation. In addition, o-VA dose-dependently ameliorated acetic acid-induced vascular permeability and zymosan-induced leukocyte migration. Thus, we suggest that o-VA can be used as a pharmacological agent or food supplement in the treatment of inflammatory conditions.

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Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effect of <i>o</i>-Vanillic Acid on Lipopolysaccharide-Stimulated Macrophages and Inflammation Models

Lee¹,

Lee²,

Shin³

et al. 2018

JFNR

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show abstract

“…An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain. Analgesics include paracetamol, the nonsteroidal antiinflammatory drugs (NSAIDs) such as the salicylates, and opioid drugs such as morphine and oxycodone [78].…”

Section: Analgesic Antiinflammatory and Antiplatelet Activitymentioning

confidence: 99%

Schiff Bases as Important Class of Pharmacological Agents

Dzeikala¹,

Sykuła²

2018

JPP

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Therapeutics are compounds, which do not always exhibit healing powers. They sometimes prevent or control roles. Many compounds, well known or less are treated as the therapeutic agents. Among them, there is a specific group of molecules named commonly as Schiff bases, chemically imines. Schiff bases are aldehyde-or ketone-like compounds in which the carbonyl group is replaced by an imine -HN=СН-or azomethine -NHN=СН-group, they are an important class of compounds for new drug development. Schiff base modifications so far proved to be very effective with increased efficacy and reduced toxicity. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activity. The aim of this work was to present some interesting and promising examples of Schiff bases which exhibit biological activity.

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“…Other adverse effects of NSAIDS and aspirin include enteropathy, mucosal damage, intestinal strictures, ulcers, colitis and rectitis. Acetaminophen can cause liver necrosis and fatal liver damage when overdosed ( 30 , 31 ). Based upon the above evidence, NSAIDs may not be recommended for treating IBS pain.…”

Section: Conventional Pain Managing Drugs Adopted For the Visceramentioning

confidence: 99%

Pharmacological Approach for Managing Pain in Irritable Bowel Syndrome: A Review Article

2017

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ContextVisceral pain is a leading symptom for patients with irritable bowel syndrome (IBS) that affects 10% - 20 % of the world population. Conventional pharmacological treatments to manage IBS-related visceral pain is unsatisfactory. Recently, medications have emerged to treat IBS patients by targeting the gastrointestinal (GI) tract and peripheral nerves to alleviate visceral pain while avoiding adverse effects on the central nervous system (CNS). Several investigational drugs for IBS also target the periphery with minimal CNS effects.Evidence of AcquisitionIn this paper, reputable internet databases from 1960 - 2016 were searched including Pubmed and ClinicalTrials.org, and 97 original articles analyzed. Search was performed based on the following keywords and combinations: irritable bowel syndrome, clinical trial, pain, visceral pain, narcotics, opioid, chloride channel, neuropathy, primary afferent, intestine, microbiota, gut barrier, inflammation, diarrhea, constipation, serotonin, visceral hypersensitivity, nociceptor, sensitization, hyperalgesia.ResultsCertain conventional pain managing drugs do not effectively improve IBS symptoms, including NSAIDs, acetaminophen, aspirin, and various narcotics. Anxiolytic and antidepressant drugs (Benzodiazepines, TCAs, SSRI and SNRI) can attenuate pain in IBS patients with relevant comorbidities. Clonidine, gabapentin and pregabalin can moderately improve IBS symptoms. Lubiprostone relieves constipation predominant IBS (IBS-C) while loperamide improves diarrhea predominant IBS (IBS-D). Alosetron, granisetron and ondansetron can generally treat pain in IBS-D patients, of which alosetron needs to be used with caution due to cardiovascular toxicity. The optimal drugs for managing pain in IBS-D and IBS-C appear to be eluxadoline and linaclotide, respectively, both of which target peripheral GI tract.ConclusionsConventional pain managing drugs are in general not suitable for treating IBS pain. Medications that target the GI tract and peripheral nerves have better therapeutic profiles by limiting adverse CNS effects.

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The Role of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in the Treatment of Patients With Hepatic Disease: A Review Article

Cited by 25 publications

References 63 publications

Anti-Inflammatory Effect of <i>o</i>-Vanillic Acid on Lipopolysaccharide-Stimulated Macrophages and Inflammation Models

Anti-Inflammatory Effect of <i>o</i>-Vanillic Acid on Lipopolysaccharide-Stimulated Macrophages and Inflammation Models

Schiff Bases as Important Class of Pharmacological Agents

Pharmacological Approach for Managing Pain in Irritable Bowel Syndrome: A Review Article

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