The role of noncoding RNA and its diagnostic potential in intrahepatic cholestasis of pregnancy: a research update

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is a common liver disorder that generally occurs during the second or third trimester of pregnancy. It rarely causes any harm to the mother; however, it can result in short- and long-term complications in the offspring. Therefore, it is crucial to diagnose and treat this condition to avoid poor pregnancy outcomes. The identification of novel markers with potential diagnostic, prognostic, and therapeutic utility in ICP has gained attention. Noncoding RNAs (ncRNAs), including microRNA, long noncoding RNA, and circular RNA, are a type of transcripts that are not translated into proteins. They possess vital biological functions, including transcriptional and translational regulation and DNA, RNA, and protein interactions. The pathogenesis of ICP is related to the aberrant expression of several circulating or placenta-related ncRNAs. In this review, we summarized all recent findings on ncRNAs and ICP and outlined the concepts that form the basis for the early diagnosis and targeted treatment of ICP.

Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans

“…Peripheral blood analysis is usually performed as part of routine clinical care, and hence, we analyzed the serum for discovering a lncRNA whose levels may indicate mTBI. LncRNAs are detected in blood (serum or plasma) and many studies have previously shown a correlation between the circulating levels of lncRNA and diseases such as diabetes and cancers [45][46][47][48][49][50][51]. LncRNAs are regulatory RNAs longer than 200 nucleotides without open reading frames, and hence, they do not code for a protein.…”