The role of nonspecific inflammation factors – SA-A and pentraxin-3 in patients with respiratory sarcoidosis in different age groups

PTX3 in Granuloma Formation and Sarcoidosis: Helping Macrophages Accept a “Complement”

“…Within this superfamily is PTX3 (pentraxin 3), a proinflammatory molecule whose manifold properties include macrophage activation ( 5 , 6 ) and complement-dependent inflammatory ( 7 , 8 ) and remodeling ( 9 ) functions. Interestingly, despite previous work describing PTX3 ( 10 ) or complement anomalies ( 11 , 12 ) in sarcoidosis, until recently the evidence connecting these entities has been scant.…”