“…It appears that by sending the letter (low touch) and calling prospective participants via the phone call (high touch), study coordinators were able to establish contact with individuals, who were aware of the study and their eligibility, to discuss the trial and presumably, address participants' questions or concerns during this critical interaction. This confirms the benefits of using communication strategies that can establish a connection and maintain trust with prospective participants to increase recruitment [22] and accrual [10] , [22] , [23] , it underscores the utility of approaching clinical recruiting similar to other persuasive communication encounters; in order to effectively recruit and enroll participants into clinical studies, recruiters must engage strategies that provide opportunities for framing study participation in terms of the participant's needs, rather than strictly providing (e.g., sending a letter) information about the study [23] . Future studies should evaluate participant's preferences for being recruited into clinical studies, specifically individuals who have enrolled in a registry, been contacted about research, and declined to participate.…”