The role of NOS2 and NOS3 in renal protein and arginine metabolism during early endotoxemia in mice

Luiking, Yvette C.; Hallemeesch, Marcella M.; Lamers, Wouter H.; Deutz, N.E.P.

doi:10.1152/ajprenal.00308.2004

Cited by 7 publications

(5 citation statements)

References 36 publications

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“…Unlike WT mice, NOS3 Ϫ/Ϫ mice did not increase citrulline production (production even decreased in NOS3 Ϫ/Ϫ mice). This seems in line with the observation that these mice did not increase plasma arterial citrulline after LPS (30).…”

Section: Role Of Nos2 and Nos3 In Endotoxemiasupporting

confidence: 92%

“…In these mice, arterial plasma citrulline increased from 70 to 90 mM after LPS (30). Unlike WT mice, NOS3 Ϫ/Ϫ mice did not increase citrulline production (production even decreased in NOS3 Ϫ/Ϫ mice).…”

Section: Role Of Nos2 and Nos3 In Endotoxemiamentioning

confidence: 82%

“…On the whole body level, a change toward a catabolic state was observed in response to endotoxemia in these mice (decreased protein synthesis with net protein breakdown; see Ref. 30), probably representing mainly reduced splanchnic protein metabolism (12).…”

Section: Endotoxemiamentioning

confidence: 90%

“…Alanine is an important gluconeogenic amino acid that, like glutamine, is derived from glutamic acid in muscle, confirming that glutamine metabolism in muscle is related to NOS2 activity. Because the reduced uptake of glutamic acid and branched-chain amino acid in NOS2 Ϫ/Ϫ mice is not accompanied by a reduced arterial concentration of these amino acids (30), these changes in muscle amino acid metabolism may relate to the tendency of reduced blood flow to the hindquarter in NOS2 Ϫ/Ϫ mice. Alternatively, it is possible that the change in muscle glutamine metabolism in NOS2 Ϫ/Ϫ mice is the consequence of a compensatory change in NOS1 and/or NOS3 activity.…”

Section: Baselinementioning

confidence: 99%

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NOS3 is involved in the increased protein and arginine metabolic response in muscle during early endotoxemia in mice

Luiking¹,

Hallemeesch²,

Lamers³

et al. 2005

American Journal of Physiology-Endocrinology and Metabolism

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Section: Role Of Nos2 and Nos3 In Endotoxemiasupporting

confidence: 92%

Section: Role Of Nos2 and Nos3 In Endotoxemiamentioning

confidence: 82%

Section: Endotoxemiamentioning

confidence: 90%

Section: Baselinementioning

confidence: 99%

See 2 more Smart Citations

NOS3 is involved in the increased protein and arginine metabolic response in muscle during early endotoxemia in mice

Luiking¹,

Hallemeesch²,

Lamers³

et al. 2005

American Journal of Physiology-Endocrinology and Metabolism

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“…1,2,21) Partial inhibition of NOS activity may have beneficial effects on alleviating arginine deficiency and inhibiting excess NO-induced complications in inflammation. 6,7,14) However, both animal and human studies have shown inconsistent results on the therapeutic effects of NOS inhibitors.…”

Section: Discussionmentioning

confidence: 99%

Dose Effects of Chronically Infused Nitric Oxide Synthase Inhibitor NG-Nitro-L-arginine Methyl Ester on Anabolic Response and Arginine Metabolism in Rats with Subacute Peritonitis

Hsiao

Lee

Tsao

et al. 2011

Biological & Pharmaceutical Bulletin

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Patients with peritonitis develop arginine deficiency due to decreased consumption, impaired absorption, and increased utilization of arginine.1,2) Arginine, a precursor for the synthesis of nitric oxide (NO), urea, creatinine, glutamate, proline, and polyamines, is a conditionally essential amino acid in stressed conditions, especially in inflammation. 1,3,4) Green et al. 5) was the first research group to show that nitrate/nitrite concentrations and the severity of infection are closely correlated. Subsequent studies showed that patients with peritonitis have uncontrolled activation of inducible nitric oxide synthase (NOS), which results in NO overproduction and the following sepsis.6) Therefore, inhibition of NOS might be a useful strategy to treat arginine deficiency and inhibit excess NO production. 6,7) In animal and human studies, the results of NOS inhibition in inflammation have been ambiguous. For example, N G -nitro-L-arginine methyl ester (L-NAME), a nonselective NOS inhibitor which inhibits both constitutive and inducible NOS, effectively ameliorated the inflammatory lesions in the skin of zinc-deficient rats, 8) improved the myocardial function in sepsis, 9) and attenuated the lipopolysaccharide-induced peritoneal permeability and NO release in mice.10) On the contrary, some studies have shown that L-NAME may cause hypertension, augment the expressions of interferon (IFN)-g and interleukin (IL)-2, and result in markedly severe disease in rats with T cell-dependent autoimmune interstitial nephritis.11) The adverse effects of NOS inhibitors have also been observed in subjects with hemodynamic instability and sepsis. [12][13][14] Evidence suggests that the therapeutic effects of NOS inhibitors may depend on the dose, timing, and the severity and category of diseases.In clinical practice, a number of in hospital patients with subacute peritonitis developed chronic malnutrition and inflammation. Administration of total parenteral nutrition solution is an efficient method to supply all daily nutrition requirements; however, it is associated with occurrence of increased complicated infections.15) Zheng et al. 16) indicated that long-term parenteral nutrition-induced liver steatosis may be attenuated by L-NAME administration. Up to now, only few reports have described the long-term application of L-NAME for subacute peritonitis. Additionally, no study has ever addressed the effects of L-NAME on the inflammatory response and amino acid metabolism in subjects administered parenteral nutrition. In our study, we used a rat model with subacute peritonitis induced by cecal puncture and administered total parenteral nutrition solution to provide adequate nutrition, and we investigated the dose effects of parenterally supplemented L-NAME on the anabolism, inflammatory response, and arginine-derived metabolites such as the intermediates of the urea cycle, circulating profile of amino acids, NO, and cytokines. MATERIALS AND METHODS Animals and Experimental DesignMale Wistar rats (8-9 weeks old), initially weighi...

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Critical Assessment of Animal Models of Acute Renal Failure

Heyman¹,

Rosenberger²,

Rosen³

2009

Critical Care Nephrology

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The role of NOS2 and NOS3 in renal protein and arginine metabolism during early endotoxemia in mice

Cited by 7 publications

References 36 publications

NOS3 is involved in the increased protein and arginine metabolic response in muscle during early endotoxemia in mice

NOS3 is involved in the increased protein and arginine metabolic response in muscle during early endotoxemia in mice

Dose Effects of Chronically Infused Nitric Oxide Synthase Inhibitor NG-Nitro-L-arginine Methyl Ester on Anabolic Response and Arginine Metabolism in Rats with Subacute Peritonitis

Critical Assessment of Animal Models of Acute Renal Failure

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