The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia

Smith, Kristin; Boules, Mona; Williams, Katrina; Fauq, Abdul H.; Richelson, Elliott

doi:10.1016/j.bbr.2011.06.014

Cited by 15 publications

(14 citation statements)

References 45 publications

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“…The same analogs also produced potent antiallodynic and antihyperalgesic effects in nerve injured rats, a model of neuropathic pain (Guillemette et al, 2012). Systemic injection of NT analogs NT69L, NT72 (NTS1-selective), and NT77 causes analgesia in the HP test (Tyler et al, 1998a, 1999; Boules et al, 2001c; Smith et al, 2011) with synergy to morphine (Boules et al, 2009). Additionally, NT69L and NT72, significantly reduce acetic acid-induced writhing (Smith et al, 2012).…”

Section: Nt and Neuropsychiatric Disordersmentioning

confidence: 99%

“… Y = has an effect; N = has no effect . 1 Tyler-McMahon et al (2000b), Boules et al (2009), Smith et al (2011); 2 Smith et al (2012); 3 Roussy et al (2008), Roussy et al (2009); 4 Guillemette et al (2012); 5 Boules et al (2001c); 6 Boules et al (2010); 7 Boules et al (2011a); 8 Boules et al (2012); 9 Roussy et al (2008), Roussy et al (2009) .…”

Section: Nt and Neuropsychiatric Disordersmentioning

confidence: 99%

See 1 more Smart Citation

Diverse Roles of Neurotensin Agonists in the Central Nervous System

Boules¹,

Li²,

Smith³

et al. 2013

Front. Endocrinol.

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113

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Neurotensin (NT) is a tridecapeptide that is found in the central nervous system (CNS) and the gastrointestinal tract. NT behaves as a neurotransmitter in the brain and as a hormone in the gut. Additionally, NT acts as a neuromodulator to several neurotransmitter systems including dopaminergic, sertonergic, GABAergic, glutamatergic, and cholinergic systems. Due to its association with such a wide variety of neurotransmitters, NT has been implicated in the pathophysiology of several CNS disorders such as schizophrenia, drug abuse, Parkinson’s disease (PD), pain, central control of blood pressure, eating disorders, as well as, cancer and inflammation. The present review will focus on the role that NT and its analogs play in schizophrenia, endocrine function, pain, psychostimulant abuse, and PD.

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Section: Nt and Neuropsychiatric Disordersmentioning

confidence: 99%

Section: Nt and Neuropsychiatric Disordersmentioning

confidence: 99%

Diverse Roles of Neurotensin Agonists in the Central Nervous System

Boules¹,

Li²,

Smith³

et al. 2013

Front. Endocrinol.

Self Cite

113

View full text Add to dashboard Cite

show abstract

“…They cause severe hypothermia (< 30°C) and require significant re-warming measures [74-77]. Furthermore, hypothermic tolerance or drug resistance has been reported [74-77]. In general, however, the novel neurotensin (8-13) analogs are promising for the treatment of acute stroke in clinical settings.…”

Section: Drug-induced Hypothermia In Ischemic Strokementioning

confidence: 99%

Drug-Induced Hypothermia in Stroke Models: Does it Always Protect?

Zhang

Wang

Zhao

et al. 2013

CNSNDDT

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Ischemic stroke is a common neurological disorder lacking a cure. Recent studies show that therapeutic hypothermia is a promising neuroprotective strategy against ischemic brain injury. Several methods to induce therapeutic hypothermia have been established; however, most of them are not clinically feasible for stroke patients. Therefore, pharmacological cooling is drawing increasing attention as a neuroprotective alternative worthy of further clinical development. We begin this review with a brief introduction to the commonly used methods for inducing hypothermia; we then focus on the hypothermic effects of eight classes of hypothermia-inducing drugs: the cannabinoids, opioid receptor activators, transient receptor potential vanilloid, neurotensins, thyroxine derivatives, dopamine receptor activators, hypothermia-inducing gases, adenosine, and adenine nucleotides. Their neuroprotective effects as well as the complications associated with their use are both considered. This article provides guidance for future clinical trials and animal studies on pharmacological cooling in the setting of acute stroke.

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“…: 004608) were purchased from Jackson Laboratory, and HT male were intercrossed with HT female after P42 (Figure 3, Step 1). HT mice were maintained with occa-sional backcrosses to C57BL/6J (B6) to avoid inbreeding depression, that is, loss of reproductive fitness by inbreeding processes 2,24,40,41 . Because the motor neuron disease-like phenotype did not appear before P15 in the mnd2 mice, the phenotypic difference between littermates could not be recognized initially.…”

Section: Experiments-based Genotype Analysis Of Mnd2 Micementioning

confidence: 99%

A Simple and Accurate Genotype Analysis of the motor neuron degeneration 2 (mnd2) Mice: an Easy-to-Follow Guideline and Standard Protocol Applicable to Mutant Mouse Models.

Rhim

Shin²,

Kim³

et al. 2012

Interdisciplinary Bio Central

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The motor neuron degeneration 2 (mnd2) mice carry a point mutation of A to T nucleotide transversion at the serine 276 residue of high temperature requirement A2 (HtrA2), resulting in losses of an AluI restriction enzyme site (5'AGCT3') and the HtrA2 serine protease activity. Moreover, dysfunctions of HtrA2 are known to be intimately associated with the pathogenesis of neurodegenerative diseases, including Parkinson's disease. Thus, this mnd2 mouse is an invaluable model for understanding the physiological role of HtrA2 and its pathological role in neurodegenerative diseases. Nevertheless, many molecular and cellular biologists in this field have limited experience in working with mutant mouse models due to the necessity of acquired years of the special techniques and knowledges. Herein, using the mnd2 mouse model as an example, we describe easy-touse standard protocols for web-based analyses of target genes, such as HtrA2, and a novel approach for simple and accurate PCR-AluI-RFLP-based genotype analysis of mnd2 mice. In addition, band resolution of AluI-RFLP fragments was improved in 12% polyacrylamide gel running in 1X Tris-Glycine SDS buffer. Our study indicates that this PCR-AluI-RFLP genotype analysis method can be easily applied by the molecular and cellular biologist to conduct biomedical science studies using the other mutant mouse models.

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The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia

Cited by 15 publications

References 45 publications

Diverse Roles of Neurotensin Agonists in the Central Nervous System

Diverse Roles of Neurotensin Agonists in the Central Nervous System

Drug-Induced Hypothermia in Stroke Models: Does it Always Protect?

A Simple and Accurate Genotype Analysis of the motor neuron degeneration 2 (mnd2) Mice: an Easy-to-Follow Guideline and Standard Protocol Applicable to Mutant Mouse Models.

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