The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: A review

Iranshahy, Milad; Iranshahi, Mehrdad; Abtahi, Seyed Reza; Karimi, Gholamreza

doi:10.1016/j.fct.2018.07.024

Cited by 84 publications

(59 citation statements)

References 140 publications

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“…Also, the consequences of DNA damage, including growth arrest, cell senescence, and apoptosis, are all increased in plaque microenvironment and their levels are correlated with increased severity of atherosclerosis . Additionally, the Nrf2, which controls the expression of antioxidant response element‐dependent genes to regulate cellular resistance to oxidants, is an universal guardian against oxidative and electrophilic stresses induced by toxicants in human organs and/or tissues, especially for cardiovascular system, and a key marker for cellular oxidative stress . Intriguingly, altered expression of Nrf2 is also associated with atherosclerosis .…”

Section: Discussionmentioning

confidence: 99%

“…The intracellular redox statuses of HUVECs exposed to these NPs were also explored through the measurement of the levels of reactive oxygen species (ROS) production and reduced glutathione (GSH), respectively. The protein levels of nuclear factor erythroid 2‐related factor 2 (Nrf2), a key protein in the antioxidant defense system of mammalian cells and a critical marker for cellular oxidative stress, were also detected by western blot. We mainly focused on the size‐dependent oxidative‐genotoxicity of TiO 2 ‐NP exposure on HUVECs in culture.…”

Section: Introductionmentioning

confidence: 99%

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The size‐dependent genotoxic potentials of titanium dioxide nanoparticles to endothelial cells

Liao

Chen

Liu

et al. 2019

Environmental Toxicology

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Despite intensive research activities, there are still many major knowledge gaps over the potential adverse effects of titanium dioxide nanoparticles (TiO2‐NPs), one of the most widely produced and used nanoparticles, on human cardiovascular health and the underlying mechanisms. In the present study, alkaline comet assay and cytokinesis‐block micronucleus test were employed to determine the genotoxic potentials of four sizes (100, 50, 30, and 10 nm) of anatase TiO2‐NPs to human umbilical vein endothelial cells (HUVECs) in culture. Also, the intracellular redox statuses were explored through the measurement of the levels of reactive oxygen species (ROS) and reduced glutathione (GSH) with kits, respectively. Meanwhile, the protein levels of nuclear factor erythroid 2‐related factor 2 (Nrf2) were also detected by western blot. The results showed that at the exposed levels (1, 5, and 25 μg/mL), all the four sizes of TiO2‐NPs could elicit an increase of both DNA damage and MN frequency in HUVECs in culture, with a positive dose‐dependent and negative size‐dependent effect relationship (T100 < T50 < T30 < T10). Also, increased levels of intracellular ROS, but decreased levels of GSH, were found in all the TiO2‐NP‐treated groups. Intriguingly, a very similar manner of dose‐dependent and size‐dependent effect relationship was observed between the ROS test and both comet assay and MN test, but contrary to that of GSH assay. Correspondingly, the levels of Nrf2 protein were also elevated in the TiO2‐NP‐exposed HUVECs, with an inversely size‐dependent effect relationship. These findings indicated that induction of oxidative stress and subsequent genotoxicity might be an important biological mechanism by which TiO2‐NP exposure would cause detrimental effects to human cardiovascular health.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The size‐dependent genotoxic potentials of titanium dioxide nanoparticles to endothelial cells

Liao

Chen

Liu

et al. 2019

Environmental Toxicology

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“…Supplementation with lycopene decreased oxidative stress which could be related to a reduction in protein carbonylation in acetaminophen (500 mg/kg, orally) induced hepatotoxicity in C57BL/6 mice. Lycopene has also been reported to suppress production of ROS in SK‐Hep1 cells .…”

Section: Chemical Induced Toxicitymentioning

confidence: 99%

“…The in vitro antioxidant potency of lycopene, up to 100 times more efficient than vitamin E, its chemopreventive activity [2] against certain types of cancers, and its protective activity against chemotherapeutic-induced renal damage have attracted considerable research activity in recent years [3]. Lycopene has been widely used in traditional medicine and has been reported to have protective effects on treatment of cardiovascular diseases [4], neurotoxicity [5], hepatic injury [6], nephrotoxicity [7], as an antioxidant [8], and as an antiapoptotic agent [9]. The protective role of lycopene on toxicant induced toxicity is discussed in this review.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of lycopene against chemical and natural toxins: A review

et al. 2018

Self Cite

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People are exposed to a number of environmental, occupational, and therapeutic toxic agents which may be natural or man made. These hazardous substances may manifest as direct side effects on the function of organs or indirectly induced alteration of gene expression, cancer‐associated metabolic pathways, and/or alter homeostasis. Lycopene, as a one of the most potent antioxidant, is found in fruits and vegetables. High‐intake of lycopene has been shown to be effective in decreasing the risk of both natural toxins including mycotoxins, bacterial toxins, and chemical toxins including heavy metals, pesticides as well as herbicides. Recently, there is growing attention in understanding the mechanisms of the phytochemicals and carotenoids as antioxidative, antiapoptotic, radical scavenging, and chelating agents and their roles in the modulation of inflammatory pathways. This review summarizes available data from several recent studies about lycopene and its role against chemical and natural toxicants. © 2018 BioFactors, 45(1):5–23, 2019

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“…Not surprisingly, there is great interest in pharmacological modulators of Nrf2 that could be developed into therapeutics for the treatment and prevention of disease (Buendia et al, ; Cuadrado et al, ; Dodson et al, ; Du et al, ; Gacesa et al, ; Kumar, Kim, More, Kim, & Choi, ; Lu, Ji, Jiang, & You, ; Rabbani, Ellison, et al, ; Sivandzade et al, ; Sklirou, Papanagnou, Fokialakis, & Trougakos, ; Sova & Saso, ; Vega, Dodson, Chapman, & Zhang, ; Yamamoto et al, ; Zhang et al, ), including skin disorders (Dodson et al, ; Ferrándiz, Nacher‐Juan, & Alcaraz, ; Gacesa et al, ; Kumar et al, ; Lu et al, ; Penta, Somashekar, & Meeran, ; Rabbani, Ellison, et al, ; Son et al, ; Yamamoto et al, ). Examples of natural products known to induce epigenetic Nrf2‐activating effects are shown in Figure (Bambouskova et al, ; Dodson et al, ; Fazzari et al, ; Fratantonio et al, ; Garaude, ; Gill, Raman, Yost, Garrett, & Vedam‐Mai, ; Gu et al, ; Iranshahy, Iranshahi, Abtahi, & Karimi, ; Irwin, Moos, Faller, Steliou, & Pinkert, ; Kumar et al, ; Li et al, ; Mathers et al, ; Matzinger, Fischhuber, & Heiss, ; Moos, Maneta, et al, ; Moos et al, ; Rigacci & Stefani, ; Rusu, Gheldiu, Mocan, Vlase, & Popa, ; Sivandzade et al, ; Steliou, Boosalis, Perrine, Sangerman, & Faller, ; Steliou, Faller, Pinkert, Irwin, & Moos, ; Tsujita et al, ). Some products are endogenously made, like the prostaglandins and l ‐carnitine as well as butyric, α‐lipoic, fumaric, itaconic, and the nitro‐fatty acids.…”

Section: Nrf2‐activating Therapeuticsmentioning

confidence: 99%

Epigenetic treatment of dermatologic disorders

Moos

Faller

Glavas

et al. 2019

Drug Development Research

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Healthy skin protects us against a multitude of insults, but injured or maladapted skin can lead to infection, inflammation, or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and other plant and vegetable extracts, have shown utility in treating skin and related diseases as well as conditioning the skin to maintain its healthy function. Powerful agents targeting nuclear regulatory pathways continue to hold promise as new or repurposed therapies for a wide variety of ills and skin conditions. Epigenetic approaches that activate Nrf2 to effect detoxification, redox balance, DNA repair, and mitochondrial function are noteworthy. Some of the disease applications being actively investigated range from eczema and psoriasis to skin cancer and diabetes‐related wound healing to name just a few.

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The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: A review

Cited by 84 publications

References 140 publications

The size‐dependent genotoxic potentials of titanium dioxide nanoparticles to endothelial cells

The size‐dependent genotoxic potentials of titanium dioxide nanoparticles to endothelial cells

Protective effect of lycopene against chemical and natural toxins: A review

Epigenetic treatment of dermatologic disorders

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