The Role of Nutritional Factors in Free-Radical Reactions

Witting, Lloyd A.

doi:10.1007/978-1-4613-9928-5_8

Cited by 4 publications

(1 citation statement)

References 184 publications

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“…Conversely, it may be feasible to administer radioisotopes via nutrients as tumor selective therapy. Thus, in the future, some tumors may conceivably be controlled by altering nutrient concentrations, adjusting formulae of TPN, substituting antagonistic ions, changing bioavailability of specific nutrients by selectively blocking or releasing active sites, administering tumor nutrient radioisotopes, using such nutrients as ascorbic acid to alter the electron spin resonance of specific metalloproteins in neoplasia, increasing dietary antioxidants to influence free-radical reactions, modifying fluid retention, or some other nutritional manipulation to affect intermediary metabolism.I, 130,[171][172][173][174][175][176][177][178][179] TPN, being chemically defined, offers a convenient vehicle both for the supportive nutrition of cancer patients as well as for precise therapeutic intervention in their metabolism. Before such changes and manipulations ofTPN formulae may be undertaken, it is necessary to have some basic insights into the metabolism, function, and mode of action of the specific nutrients in relation to cancer.…”

Section: Summarymentioning

confidence: 99%

Zinc, Copper, and Parenteral Nutrition in Cancer. A Review

Askari

Long

Blakemore

1980

J Parenter Enteral Nutr

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Literature concerning zinc and/or copper investigations pertaining to cancer is surveyed; the interrelationships of zinc, copper, and parenteral nutrition (PN) in cancer are examined; and the advantages of adequate nutritional support for patients with malignancies are discussed. Zinc and copper are both essential trace elements and, therefore, are necessary nutrients for cancer patients. Zinc supports growth, including that of neoplasia; copper is a zinc competitor and antagonist; and cancer patients on PN are in danger of becoming both zinc- and copper-deficient. The addition of these trace elements as supplements to PN formulae is undertaken with knowledge of only the approximate concentrations of zinc and copper in total intake, but without knowledge of specific requirements for cancer patients for these trace elements, of all the possible interactions of zinc and copper with each other or different trace elements, or even of zinc and copper lower levels of toxicity in cancer patients; balance studies are needed to determine zinc and copper requirements in them. In the future, it is conceivable that manipulations of the host nutrients might be used to control tumors. This might be accomplished by adjusting total PN formulae so that required nutrients will be presented to a cancer patient in such amounts and in such ratios that a desired alteration may be effected in that patient's metabolism.

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Section: Summarymentioning

confidence: 99%

Zinc, Copper, and Parenteral Nutrition in Cancer. A Review

Askari

Long

Blakemore

1980

J Parenter Enteral Nutr

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Effect of sex hormones on copper, zinc, iron nutritional status and hepatic lipid peroxidation in rats

Wachnik

Bíró

Biró

et al. 1993

Nahrung

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Sex dependence of copper, zinc, iron nutritional status and hepatic lipid peroxidation was studied in gonadectomized, hormone substituted and sham-operated male and female rats. The experiment was performed on H-Wistar rats (106 +/- 10 g) fed conventional laboratory food ad libitum for 12 weeks. The estrogen dependence of copper status is fully confirmed by the results of this study. In hormonally active females the malondialdehyde production was depressed which is supposed to be connected with high copper and low triglyceride levels in the liver. The anaemia observed in estrogen substituted rats may be a result of lower lipid peroxidation rate. The levels of retinol and alkaline phosphatase activity in sera are probably influenced by estrogen action. It is suggested that testosterone leads to acceleration of lipid peroxidation.

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Antioxidant Role of Vitamin E

Draper¹

1993

Atmospheric Oxidation and Antioxidants

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The Role of Nutritional Factors in Free-Radical Reactions

Cited by 4 publications

References 184 publications

Zinc, Copper, and Parenteral Nutrition in Cancer. A Review

Zinc, Copper, and Parenteral Nutrition in Cancer. A Review

Effect of sex hormones on copper, zinc, iron nutritional status and hepatic lipid peroxidation in rats

Antioxidant Role of Vitamin E

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