The Role of Optical Coherence Tomography Angiography in Patients With Preeclampsia

Özcan, Zeynep Özer; Güngör, Kıvanç; Saygılı, Oğuzhan; Özcan, Hüseyin Çağlayan

doi:10.1097/iae.0000000000003538

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Our study is the first to present long‐term VD indices after HDP, including VSD and VDI. Two other studies have investigated VD in preeclamptic women during pregnancy ( n = 150 and n = 98; Ciloglu et al., 2019; Özcan et al., 2022). Similar to our postpartum findings, the authors found no differences in VD during pregnancy in the superficial parafoveal area (which was equivalent to the investigated area in our study).…”

Section: Discussionmentioning

confidence: 99%

Retinal oximetry and microvascular assessment after hypertensive pregnancy complications

Hoel,

Moe,

Sugulle

et al. 2024

Acta Ophthalmologica

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PurposeWomen with hypertensive disorders of pregnancy (HDP) are at increased risk of developing premature cardiovascular disease (CVD). The mechanisms behind this are not fully understood, but microvascular alterations have been documented in retinal arterioles and venules. The aim of this study was to use non‐invasive retinal imaging to investigate the structural and functional properties of arterioles, venules and capillaries in this patient group.MethodsWe examined 27 women with previous HDP and 23 controls at 3 years postpartum. The retinal microvasculature was assessed by vessel calibre measurements, retinal oximetry and optical coherence tomography angiography. Differences were analysed using non‐parametric tests and multiple regression analyses, adjusted for age and body mass index.ResultsMedian arteriolar oxygen saturation (SaO2; 94.2% vs. 93.0%), venular oxygen saturation (SvO2; 60.1% vs. 62.4%) and arteriovenous saturation difference (AV‐difference; 32.8% vs. 32.3%) were similar across groups. Capillary vessel density (VD; 46.2% vs. 46.3%), skeletonised VD (VSD; 21.3 vs. 21.1 mm/mm2) and vessel diameter index (21.65 vs. 21.86) were also comparable. In the HDP group, mean arterial pressure (MAP) was positively correlated with AV‐difference (R2 = 0.209) and negatively correlated with arteriolar diameter (CRAE; r2 = 0.382).ConclusionsStructural microvascular alterations appear not to be key biomarkers for CVD risk after HDP as early as 3 years postpartum in otherwise healthy women. Further studies are needed to evaluate whether such changes occur later in life. MAP was associated with AV‐difference only in the HDP group, suggesting specific mechanisms affecting functional microvascular properties in these women.

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Section: Discussionmentioning

confidence: 99%

Retinal oximetry and microvascular assessment after hypertensive pregnancy complications

Hoel,

Moe,

Sugulle

et al. 2024

Acta Ophthalmologica

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“…Pertaining to preeclampsia, similar findings to those detected in hypertension have been observed. Both the superficial and deep foveal & parafoveal densities were recorded to be significantly lower in preeclamptic women compared to healthy pregnant & non-pregnant individuals [ 32 , 33 ]. Hata et al [ 34 ] documented diminished pulsatility in the ophthalmic artery in preeclamptic patients compared to healthy pregnant women using Doppler imaging.…”

Section: Discussionmentioning

confidence: 99%

Diminished choroidal blood flow in hypertensive and preeclamptic third trimester pregnancies using optical coherence tomography angiography

et al. 2023

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Purpose The aim of this study was to compare choroidal adjusted flow index (AFI) in healthy, hypertensive & preeclamptic pregnancies using optical coherence tomography angiography (OCTA). Methods In this prospective study, healthy, hypertensive & preeclamptic third trimester pregnant women underwent OCTA imaging. 3x3 & 6x6 mm choriocapillaris slabs were exported and the parafoveal area was marked by two concentric ETDRS circles at 1 & 3 mm, centered on the foveal avascular zone. Parafoveal AFI was calculated as a parameter of choroidal blood flow. Results Fifteen eyes of fifteen women per group were recruited (45 eyes). AFI was significantly lower in the preeclamptic compared to the healthy & hypertensive groups (Tukey HSD: <0.001 in both groups on 3x3 mm, and 0.02 & 0.04 in 6x6 mm scans), and in the hypertensive compared to the healthy group (0.005 & 0.03 in 3x3 & 6x6 mm scans respectively). Conclusions Pregnancies complicated with preeclampsia revealed the lowest choroidal blood flow on OCTA followed by pregnancies with systemic hypertension compared to healthy pregnancies. We provide in-vivo documentation of choroidal ischemia, highlighting its culpability in hypertensive and preeclamptic retinochoroidal pathology, and the possibility of utilizing choroidal blood flow on OCTA as a precursor for disease progression.

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Vascular changes in macula, optic disc, and choroid in Wilson's disease: A cross-sectional optical coherence tomography angiography study

Seyyar

Kanat

Özcan

et al. 2023

Photodiagnosis and Photodynamic Therapy

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The Role of Optical Coherence Tomography Angiography in Patients With Preeclampsia

Cited by 3 publications

References 25 publications

Retinal oximetry and microvascular assessment after hypertensive pregnancy complications

Retinal oximetry and microvascular assessment after hypertensive pregnancy complications

Diminished choroidal blood flow in hypertensive and preeclamptic third trimester pregnancies using optical coherence tomography angiography

Vascular changes in macula, optic disc, and choroid in Wilson's disease: A cross-sectional optical coherence tomography angiography study

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