The role of oral microbiome in pemphigus vulgaris

Zorba, Matina; Melidou, Angeliki; Patsatsi, Aikaterini; Poulopoulos, Athanasios; Gioula, Georgia; Kolokotronis, Alexandros; Minti, Fani

doi:10.1007/s00203-021-02199-5

Cited by 8 publications

(8 citation statements)

References 51 publications

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“…Excessive bacterial population in teeth is the most effective source of teeth deterioration and Halitosis e. g. gingival diseases [32] . Bad body smell and bad breath are due to infections caused by M. leutus and B. subtilis [33,34] . investigated that, some bacteria such as Escherichia coli and Pseudomonas aeruginosa cause the urinary tract infections (UTIs).…”

Section: Resultsmentioning

confidence: 99%

“…[32] Bad body smell and bad breath are due to infections caused by M. leutus and B. subtilis. [33,34] investigated that, some bacteria such as Escherichia coli and Pseudomonas aeruginosa cause the urinary tract infections (UTIs). The present study on R. afghanicum might be supportive in resolving the aforementioned and many more bacterial infections.…”

Section: Anti-bacterial Activitymentioning

confidence: 99%

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Pharmacological Activities of Rhododendron afghanicum; an Endemic Species of Khyber Pakhtunkhwa, Pakistan

Alam,

Ahmad,

Ahmad

et al. 2023

Chemistry & Biodiversity

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Majority of different kinds of metabolites having therapeutic characteristics are thought to be stored in medicinal plants. So, the present study was aimed to explore the crude extract of leaves and stem of R. afghanicum for phytochemical screening and various pharmacological activities. Toxicological studies at 100 mg/kg showed 60 % mortality where its safe dose level was 90 mg/kg. Phytochemical screening revealed the presence of alkaloids, glycosides, flavonoids and tannins in both extracts. Bacterial strains were susceptible to (RLEt) and (RLM) crude extracts except Staphylococcus aureus. RSM showed maximum anti‐inflammatory activity (20.16 %) followed by RSEt (20.14 %) where lowest activity was displayed by RLEt (18.46 %). Phytotoxic activity showed a substantial dose‐dependent phyto‐inhibition of Lemna minor. An outstanding cytotoxic potential was displayed with LD50 values of 9.46 and 13.03 μg/ml in both stem extracts. RLEt demonstrated a dose‐dependent pain relief at 30, 60 and 90 mg/kg which was 31 %, 40 % and 52 % respectively. A considerable spasmolytic action was observed by the shrinkage of jejunum muscle in albino mice. RLEt at 1000 ppm showed (17 mm) and RLM at 1000 ppm showed (16 mm) zone of inhibition against Aspergillus niger. These findings support and corroborate the traditional applications of R. afghanicum for treating digestive, analgesic and inflammatory ailments.

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Section: Resultsmentioning

confidence: 99%

Section: Anti-bacterial Activitymentioning

confidence: 99%

Pharmacological Activities of Rhododendron afghanicum; an Endemic Species of Khyber Pakhtunkhwa, Pakistan

Alam,

Ahmad,

Ahmad

et al. 2023

Chemistry & Biodiversity

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“…In addition to RA, SLE, and SS, there are also other SADs not covered by this review, and few studies have investigated their oral microbiome. To the best of our knowledge, there was one study carried out by Zorba et al, who analyzed the smear samples from oral lesions of patients with pemphigus vulgaris (PV) using 16S rRNA sequencing and found that Fusobacterium nucleatum was the most dominant species (Zorba et al, 2021 ). In the future, high-throughput analysis could be used more widely to study the oral microbiome of other SADs.…”

Section: Discussionmentioning

confidence: 99%

The Oral Microbiome and Its Role in Systemic Autoimmune Diseases: A Systematic Review of Big Data Analysis

Cheng

Zhu

et al. 2022

Front. Big Data

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IntroductionDespite decades of research, systemic autoimmune diseases (SADs) continue to be a major global health concern and the etiology of these diseases is still not clear. To date, with the development of high-throughput techniques, increasing evidence indicated a key role of oral microbiome in the pathogenesis of SADs, and the alterations of oral microbiome may contribute to the disease emergence or evolution. This review is to present the latest knowledge on the relationship between the oral microbiome and SADs, focusing on the multiomics data generated from a large set of samples.MethodologyBy searching the PubMed and Embase databases, studies that investigated the oral microbiome of SADs, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and Sjögren's syndrome (SS), were systematically reviewed according to the PRISMA guidelines.ResultsOne thousand and thirty-eight studies were found, and 25 studies were included: three referred to SLE, 12 referred to RA, nine referred to SS, and one to both SLE and SS. The 16S rRNA sequencing was the most frequent technique used. HOMD was the most common database aligned to and QIIME was the most popular pipeline for downstream analysis. Alterations in bacterial composition and population have been found in the oral samples of patients with SAD compared with the healthy controls. Results regarding candidate pathogens were not always in accordance, but Selenomonas and Veillonella were found significantly increased in three SADs, and Streptococcus was significantly decreased in the SADs compared with controls.ConclusionA large amount of sequencing data was collected from patients with SAD and controls in this systematic review. Oral microbial dysbiosis had been identified in these SADs, although the dysbiosis features were different among studies. There was a lack of standardized study methodology for each study from the inclusion criteria, sample type, sequencing platform, and referred database to downstream analysis pipeline and cutoff. Besides the genomics, transcriptomics, proteomics, and metabolomics technology should be used to investigate the oral microbiome of patients with SADs and also the at-risk individuals of disease development, which may provide us with a better understanding of the etiology of SADs and promote the development of the novel therapies.

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“… 16 analyzed the difference in oral microbiota between patients with PV and healthy controls at the phylum level, and Zorba et al. 17 analyzed the relationship between halitosis and bacterial flora in patients with PV.…”

Section: Introductionmentioning

confidence: 99%

Potential correlation of oral flora with pemphigus vulgaris – A case control study

Li¹,

He²,

Hua³

et al. 2023

Journal of Dental Sciences

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The role of oral microbiome in pemphigus vulgaris

Cited by 8 publications

References 51 publications

Pharmacological Activities of Rhododendron afghanicum; an Endemic Species of Khyber Pakhtunkhwa, Pakistan

Pharmacological Activities of Rhododendron afghanicum; an Endemic Species of Khyber Pakhtunkhwa, Pakistan

The Oral Microbiome and Its Role in Systemic Autoimmune Diseases: A Systematic Review of Big Data Analysis

Potential correlation of oral flora with pemphigus vulgaris – A case control study

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