2003
DOI: 10.1016/s0302-2838(03)00088-5
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The Role of Osteopontin on Calcium Oxalate Crystal Formation

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Cited by 54 publications
(54 citation statements)
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“…Mg 2 þ and OPN play essential roles in the CaOx crystalcell interaction (Konya et al, 2003). Mg 2 þ could act as an inhibitor of crystal formation (Lieske, Farell and Deganello, 2004) while the possible role of OPN in kidney stone formation is inhibition of calcium oxalate monohydrate (COM) nucleation and reduction of the growth and aggregation of CaOx crystals (Khan et al, 2002;Yasui et al, 2002;Prat et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…Mg 2 þ and OPN play essential roles in the CaOx crystalcell interaction (Konya et al, 2003). Mg 2 þ could act as an inhibitor of crystal formation (Lieske, Farell and Deganello, 2004) while the possible role of OPN in kidney stone formation is inhibition of calcium oxalate monohydrate (COM) nucleation and reduction of the growth and aggregation of CaOx crystals (Khan et al, 2002;Yasui et al, 2002;Prat et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…Although they attribute this to surface expression of hyaluronic acid in less mature cultures, it may be significant that OPN was also expressed at the surface of proliferating cells. Koyna et al [18]have demonstrated increased adherence and aggregation of CaOx seed crystals to OPN-coated collagen granules. Thus, it appears that OPN immobilized on surfaces may increase CaOx adherence and, in solution, inhibit it.…”
Section: Opn and Crystal Formation In Vitromentioning
confidence: 99%
“…For this reason, in such industries, alternative additives preventing the occurrence of calcium oxalate deposition are needed. On the other hand, calcium oxalate is the primary constituent of more than 60% of the majority of human kidney stones which are aggregates [7].…”
Section: Introductionmentioning
confidence: 99%